Recombinant Mouse Calsenilin (Kcnip3)

1. DREAM inhibition markedly improves ATF6 processing in the hippocampus and that it might contribute to a delay in memory decline in Huntington mice. PMID: 29523177
2. Genome-wide analysis of trigeminal neurons in daDREAM transgenic mice identified cathepsin L and the monoglyceride lipase as two new DREAM transcriptional targets related to pain. PMID: 26896746
3. Our findings demonstrate for the first time that DREAM plays an important role in thrombosis and hemostasis in mice. PMID: 27903531
4. association of PS1 carboxyl peptide (residues 445-467, HL9) with DREAM is calcium dependent and stabilized by a cluster of three aromatic residues: F462 and F465 from PS1 and F252 from DREAM. PMID: 27009418
5. DREAM plays an important role in structural plasticity in the hippocampus. PMID: 26928278
6. Terbium(III) binding preserves the folding state of DREAM with minimal changes to overall structure of DREAM. PMID: 26901070
7. Results presented in this study show for the first time that down-regulation of DREAM promotes the degeneration of RGCs, amacrine cells, and bipolar cells. PMID: 26020793
8. The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM. PMID: 26108881
9. The protein DREAM decreases development of L-DOPA-induced dyskinesia in mice and reduces L-DOPA-induced expression of FosB, phosphoacetylated histone H3, and dynorphin-B in the striatum PMID: 24857398
10. NS5806 directly interacts with KChIP3 and modulates the interactions between this calcium-binding protein and the T1 domain of the Kv4.3 channels through reorientation of helix 10 on KChIP3 PMID: 25228688
11. These results provide the first evidence that DR/C/K3 plays a timing-dependent role in estradiol regulation of learning, memory, and plasticity. PMID: 24248121
12. DREAM is a major master switch transcription factor. PMID: 24366545
13. GCM1-directed villous trophoblast differentiation is repressed by DREAM PMID: 23300953
14. Expression of DREAM in neuroblastoma cells enhances cisplatin mediated caspase-3 activity. PMID: 23524266
15. Restoring CANT1 levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation PMID: 22451650
16. In cardiomyocytes, [Ca2+]i-activated calmodulin kinase II (CaMKII) activates downstreamregulatory element (DRE) binding transcription factor DREAM, which consequently suppresses the expression of L-type calcium channel 1C-subunit gene (Cacna1c). PMID: 21486818
17. Sumoylation regulates the nuclear localization of DREAM in differentiated neurons. PMID: 21070824
18. endogenous BDNF is involved in spinal sensitization following inflammation and blockade of BDNF induction in DREAM transgenic mice underlies the failure to develop spinal sensitization PMID: 21167062
19. Results demonstrate that DREAM plays a novel role in postsynaptic modulation of the NMDA receptor, and contributes to synaptic plasticity and behavioral memory. PMID: 20205763
20. Increased B cell proliferation and reduced Ig production in DREAM transgenic mice. PMID: 21059893
21. Calsenilin and presenilin 1 can interact at physiologic levels; calsenilin is a developmentally regulated protein that is expressed primarily in the cerebellum and hippocampus. PMID: 12207970
22. Results demonstrate that DREAM (DRE-antagonizing modulator) is a neural activity-stimulated late gene and suggest its involvement in adaptation to long-lasting neuronal activity. PMID: 12531529
23. Calsenilin is markedly decreased not only in the damaged cortex and CA3 region of hippocampus at 24 h after kainic acid-induced seizure but also in a cell-culture model of seizure-like activity. PMID: 12648752
24. calsenilin can be phosphorylated by casein kinase I and that its phosphorylation can be regulated by intracellular calcium PMID: 12837631
25. Abeta peptide levels are reduced in calsenilin knock-out mice, demonstrating that calsenilin affects presenilin-dependent gamma-cleavage in vivo. Long-term potentiation in the dentate gyrus of hippocampus is enhanced in calsenilin knock-out mice PMID: 14534243
26. KChIP3 transcripts were detected primarily in the layer V and deep layer VI of the cerebral cortex, the hippocampus, and the entire cerebellum. PMID: 15363885
27. Results demonstrate that prodynorphin transcription is regulated by DREAM in a calcium-dependent manner. PMID: 16621893
28. calsenilin and CtBP2 are present in synaptic vesicles and can interact in vivo PMID: 16787403
29. Expression of DREAM in various cell types coupled with the universal role of calcium raise the possibility that these factors may play similar role in other secretory cells. PMID: 17241740
30. A dense plexus of calsenilin-positive dendrites makes several basal contacts at cone pedicles, individual calsenilin-positive bipolar cell contacts five to seven cones, some calsenilin-positive dendrites also contact rod photoreceptors PMID: 18095322
31. Ca2+-induced dimerization of DREAM may partially block the putative DNA-binding site. PMID: 18201103
32. These results identify the PACAP-cAMP-Ca(2+)-DREAM cascade as a new pathway to activate GFAP gene expression during astrocyte differentiation. PMID: 18579744
33. Lack of DREAM protein enhances learning and memory and slows brain aging. PMID: 19110430
34. Male KChIP3 knockout (KO) mice showed significantly enhanced memory 24 hours after training and this study suggest a role for regulation of gene expression by KChIP3/DREAM/calsenilin in consolidation of contextual fear conditioning memories. PMID: 19223600
35. DREAM (downstream regulatory element antagonist modulator) modulates TSHR activity through a direct protein-protein interaction that promotes coupling between the receptor and Galphas. PMID: 19299442

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KEGG: mmu:56461

STRING: 10090.ENSMUSP00000099504

UniGene: Mm.315292