Recombinant Mouse Class E basic helix-loop-helix protein 40 (Bhlhe40)

1. Loss of Bhlhe40 expression is associated with impaired long term potentiation and long term depression at CA1 synapses. PMID: 29715265
2. This study demonstrates that downregulation of DEC1 contributes to MPP(+) -induced neurotoxicity by suppressing PI3K/Akt/GSK3beta pathway. PMID: 28734031
3. These results indicate that Bhlhe40 works as a cofactor of T-bet for enhancing IFN-gamma production in iNKT cells. PMID: 27226296
4. Bhlhe40 expression identifies encephalitogenic Th cells and defines a PTX-IL-1-Bhlhe40 pathway active in experimental autoimmune encephalomyelitis. PMID: 26834156
5. Collectively, the data obtained in this study suggest that DEC1 is a novel negative regulator of hepatic FGF21 expression PMID: 26697751
6. establishes a crucial role of Bhlhe40 in mediating the repressive effect of hypoxia on myogenic differentiation and suggests that inhibition of Bhlhe40 or p53 may facilitate muscle regeneration after ischemic injuries PMID: 26468276
7. Data show that the bHLH transcription factors SHARP1 and SHARP2 are involved in cognitive processing by controlling insulin-like growth factor II (Igf2) expression and associated signaling cascades. PMID: 26100875
8. Data indicate that bHLH transcription factors Bhlhe40 interacts with PGC-1alpha protein (PGC-1alpha) and represses its transcriptional activity. PMID: 25963661
9. abnormal sleep and certain (endo)phenotypes of psychiatric diseases may be caused by common mechanisms involving components of the molecular clock including SHARP1 and SHARP2. PMID: 25340473
10. Study demonstrates that DEC1 is involved in osteogenesis. PMID: 24397494
11. Bhlhe40 is required positively regulates the production of GM-CSF and negatively regulates the production of IL-10 in T cells. PMID: 24699451
12. we identify DEC1 as a critical transcriptional mediator in the activation of naive CD4(+) T cells that is required for the development of a T cell-mediated autoimmune disease. PMID: 23878307
13. Bhlhe40 is a possible candidate diabetic modifier gene responsible for Dbm1 locus affecting diabetes and/or obesity through negatively controlling fatty acid oxidation in muscle. PMID: 23229312
14. Stra13 protects muscle cells from oxidative damage. PMID: 19679564
15. SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest PMID: 22905217
16. Stra13, Dec and Sharp bHLH repressors are dynamically regulated during mammary gland development and may function to regulate apoptosis PMID: 15108316
17. Hand1 and Stra13 promote cell cycle exit and restrict cells towards the Trophoblast Giant cell fate. PMID: 15196947
18. Stra13 is expressed during mouse endochondral bone development PMID: 15465485
19. RORalpha suppresses adipogenic differentiation at a later stage of differentiation by RORE-mediated stimulation of Dec1 and Dec2 expression. PMID: 22244086
20. DEC1 is one of the mediators that reset the pattern of PPARgamma2 expression in response to hypoxia. PMID: 22610404
21. Results suggest a partially redundant and bidirectional regulatory function for Dec1/2 genes in transcriptional translational feedback loops and conservation of Per1-Dec synergism between vertebrate and invertebrate clocks. PMID: 22215611
22. measured circadian locomotor behavior and clock gene expression in the SCN of Per2/Dec1/2 double- and triple-mutant mice to analyze the functional interaction of PER2 and DEC1/2 feedback on circadian pacemaker function in the SCN PMID: 22080784
23. Dec1 upregulates CD25 expression during thymocyte development and increases the number of Treg cells in the periphery. PMID: 21057086
24. a mechanism for regulation of adipogenesis by hypoxia PMID: 11879638
25. Stra13 is a negative regulator of B lymphocyte activation PMID: 11890681
26. Stra13 binds with high affinity to CACGTG class B E-box elements as a homodimer with preference for elements preceded by T and/or followed by A residues PMID: 12297495
27. DEC1 is the first transcription factor that can promote both chondrogenic differentiation and terminal differentiation PMID: 12384505
28. Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family. [dec1] PMID: 12397359
29. Data indicate that Stra13 may play an important protective role against oxidative stress in podocytes. PMID: 12594185
30. expression regulated by mSharp-1/DEC2 PMID: 12657651
31. STRA13 has a role as a circadian output regulator in the periphery PMID: 14581485
32. Dec1 and Dec2 are upregulated by clock protein PMID: 15038852
33. Marked changes in the Dec1 and Dec2 expression suggest that CLOCK plays a major role in the expression of these genes in most tissues. PMID: 16267380
34. Stra13 is involved in DNA-damage-induced apoptosis and indicate in tumorigenesis. PMID: 17347673
35. Plays an important role in postnatal myogenesis by attenuating Notch signaling to reduce myoblast proliferation and promote myogenic differentiation. PMID: 17502421
36. BHLHB2 is a new modulator of Bdnf transcription and neuronal excitability. PMID: 18234890
37. These observations collectively support the notion that overexpression of Stra13 and Dec2 links hypoxia signalling to altered circadian clock gene expression. PMID: 18342625
38. DEC1, along with DEC2, plays a role in the finer regulation and robustness of the molecular clock CLOCK/BMAL1 PMID: 18411297
39. Sharp-1 and Sharp-2 have roles as negative regulators of the molecular clock PMID: 18648504
40. These results indicate that ALK-SMAD3-Dec1 signalling provides an input pathway in the mammalian molecular clock. PMID: 19029909
41. Hepatic DEC1 mediates the ligand-dependent LXR signal to regulate the expression of genes involved in the hepatic clock system and metabolism. PMID: 19032342

Show More

Hide All

KEGG: mmu:20893

STRING: 10090.ENSMUSP00000032194

UniGene: Mm.2436