Recombinant Mouse Cyclic AMP-dependent transcription factor ATF-3 (Atf3)

1. Study reports that Atf3-deficient mice developed spontaneous tumors, and died significantly earlier than wild-type mice. PMID: 28869597
2. these data indicated that ATF3 might promote intestinal epithelial cell apoptosis in Crohn's disease via up-regulating the stability and transcription activity of p53 PMID: 29716766
3. electrophilic properties of itaconate and derivatives regulate the IkappaBzeta-ATF3 inflammatory axis; results demonstrate that targeting the DI-IkappaBzeta regulatory axis could be an important new strategy for the treatment of IL-17-IkappaBzeta-mediated autoimmune diseases PMID: 29670287
4. ATF3 in the host cells regulated a chemotherapeutic agent to immune modulation and cancer metastasis. PMID: 28784776
5. this study reveals a novel mechanism of naringenin through AMPK-ATF3-dependent negative regulation of the LPS/TLR4 signalling pathway, which thereby confers protection against murine endotoxaemia. PMID: 28004841
6. Conditional deletion of ATF3 in osteoclast precursors protects RANKL-induced osteoclast activation and bone loss. PMID: 27480204
7. Data (including data from studies using mutant, transgenic, and knockout mice) suggest that gene targets of leptin/leptin-receptor (Lep/Lepr) signaling in hypothalamic neurons regulate energy metabolism; Lep/Lepr signaling appears to up-regulate expression of Atf3 (activating transcription factor-3) in hypothalamic neurons. PMID: 29535089
8. ATF3 promotes macrophage migration and reverses M1polarized macrophages to the M2 phenotype by upregulation of TNC via the Wnt/betacatenin signaling pathway. PMID: 28714032
9. Microglia make contact through unknown neuronal signals regulated by ATF3 in hypoglossal nucleus. PMID: 28522413
10. ATF3 is involved in promoting particulate matter-induced pulmonary inflammation. PMID: 29378244
11. ATF3 inhibit the expression and release of TNF-alpha, IL-1beta, IL-6, and IL-18 induced by Mycoplasma pneumonia in vitro and in vivo, which is associated with its negative regulation of Egr-1/Fyn signaling pathway. PMID: 28440917
12. The different anti-inflammatory mechanisms of the ApoA-I cysteine mutants might be associated with the regulation of ATF3 level. PMID: 28093456
13. ATF3 is a new co-factor of c-Fos and NFATc1 to activate osteoclast differentiation and activity. PMID: 27829167
14. This study shows, for the first time, that alpha-lactalbumin isolated in a rare 28kDa dimeric form induces cell death, while 14kDa monomeric alpha-lactalbumin is inactive. PMID: 28193539
15. Results show a pro-regenerative ATF3 function during PNS nerve regeneration involving transcriptional activation of a neuropeptide-encoding regeneration-associated gene cluster. PMID: 27581653
16. Results reveal a critical role for ATF3 as a key regulator of the acinar cell transcriptional response during injury and may provide a link between chronic pancreatitis and PDAC. PMID: 28701342
17. The lung injury score and mortality were higher in ATF3 knock-out mice treated with Pseudomonas aeruginosa. Moreover, ATF3 was demonstrated to bind to lipopolysaccharide binding protein. These findings suggest ATF3 protects mice against acute lung injury induced by Pseudomonas aeruginosa partly due to the binding to lipopolysaccharide binding protein. PMID: 28662411
18. ATF3-KO mice escape from PE-dependent maladaptive cardiac remodeling by suppressing the IFNgamma-CXCL10-CXCR3 axis at multiple levels. PMID: 27870968
19. ATF3 has a protective role in dampening the high fat-induced cardiac remodeling processes. PMID: 28082453
20. ATF3 protects against LPS-induced acute lung injury by inhibiting TL1A expression. PMID: 28177121
21. Myotube contraction increased ATF3 level, which modified chemokine expression. In skeletal muscle after downhill running, ATF3 also modified chemokine expression. PMID: 28822763
22. converges with CSL in negative control of cancer-associated fibroblast activation PMID: 28684431
23. Loss of activating transcription factor 3 (ATF3) in knockout mice promotes the emergence of keratins CK5+CK8+ epithelial cells. PMID: 26522727
24. A novel role for ATF3 in the inhibition of lipopolysaccharide-induced TNF-alpha and in the impairment of monocyte and macrophage migration, is reported. PMID: 27260954
25. ATF3 attenuates the expression of inflammation-related genes after exercise and thus facilitates molecular adaptation to training. PMID: 27856557
26. The microvascular injury phenotypes observed in vitro and in vivo were similar. ATF3 plays an important role in mediating brain microvascular responses to acute and chronic lipotoxic injury and may be an important preventative and therapeutic target for endothelial dysfunction in vascular cognitive impairment . PMID: 27087439
27. ATF3 upregulation in cardiac fibroblasts in response to hypertensive stimuli protects the heart by suppressing Map2K3 expression and subsequent p38-transforming growth factor-beta signaling. PMID: 28249877
28. we have identified ATF3 as an important regulator of cisplatin cytotoxicity and that ATF3 inducers in combination with platins are a potential novel therapeutic approach for NSCLC. PMID: 27659012
29. Mechanistic studies showed that in MDSCs, ATF3 was transrepressed by the GC receptor GR through direct binding to the negative GR-response element. S100A9 is the major transcriptional target of ATF3 in Granulocytic Myeloid-derived Suppressor Cells. PMID: 27573240
30. These findings suggest that Atf3 is implicated in the pathogenesis of osteoarthritis through modulation of inflammatory cytokine expression in chondrocytes. PMID: 27159257
31. cigarette smoke exposure up-regulated the expression of ATF3 in mice PMID: 28185985
32. Study shows that ATF3 regulates multiple targets in cardiomyocytes and plays critical roles in hypertrophy, apoptosis and autophagy of cardiomyocyte. PMID: 26780683
33. ATF3 was up-regulated in brain after reperfusion following transient middle cerebral artery occlusion. PMID: 26900013
34. Activating transcription factor 3 represses inflammatory responses by binding to the p65 subunit of NF-kappaB PMID: 26412238
35. Knockout of the ATF3 gene reduced the stimulatory effect of TGFbeta on fibroblasts by interfering with canonical Smad signalling and protected the mice from experimental fibrosis in two different models. PMID: 25589515
36. ATF3 is a key regulator in cardiac hypertrophy through a cross-talk between cardiomyocytes and macrophages. PMID: 26201690
37. Data show that activating transcription factor 3 (ATF3) acted as a transcriptional repressor and regulated interferon-beta (IFN-beta) via direct binding to a regulatory site distal to the Ifnb1 promoter. PMID: 26416280
38. ATF3 binds to carboxyl-terminal modulator protein and suppresses its transcription following brain ischemia. PMID: 24771044
39. Involvement of ATF3 in the negative regulation of iNOS expression and NO production in activated macrophages PMID: 25752455
40. ATF3 suppresses fibrosis early but not late during infarct-induced heart failure. Although ATF3 deficiency was associated with more fibrosis, this did not occur at the expense of survival, which was higher in the ATF3-null mice. PMID: 26342068
41. these results demonstrate that during acute inflammation Atf3 negatively regulates Ptgs2 PMID: 25619459
42. results thus link ATF3 to the AKT signaling, and suggest that ATF3 is a tumor suppressor for the major subset of prostate cancers harboring dysfunctional Pten PMID: 25531328
43. ATF3 confers protection to lung injury by preventing inflammatory cell recruitment and barrier disruption in a cell-specific manner, ATF3 deletion releases Nrf2 from ATF3-mediated transcriptional inhibition; however, absence of ATF3 results in Nrf2 proteasomal degradation. PMID: 25401197
44. Results showed that PLY induces ATF3 expression during infection when bound to TLR4 and TLR2/4 regulate ATF3 induction via the JNK/p38 pathway. PMID: 25518930
45. our data demonstrate that a cell-autonomous program consisting of a stress-induced Atf3-gelsolin cascade affects the change in dendritic spine morphology in models of tuberous sclerosis complex PMID: 26224859
46. Activation of ATF3 by endoplasmic reticulum stress is essential for the cardioprotective effects of late ischemic preconditioning. PMID: 25151953
47. Ethanol exposure blocked the recruitment of CREB and its coactivator CRTC2 to gluconeogenic promoters by up-regulating ATF3, a transcriptional repressor that also binds to cAMP-responsive elements PMID: 25730876
48. ATF3-mediated inhibition of PPARgamma expression may contribute to inhibition of adipocyte differentiation during cellular stress including ER stress. PMID: 25445599
49. resveratrol enhances the renal expression of the anti-aging Klotho gene, and the transcriptional factors ATF3 and c-Jun functionally interact and coordinately regulate the resveratrol-mediated transcriptional activation of Klotho. PMID: 24911970
50. ATF3 interacts with PPARgamma and represses PPARgamma-mediated transactivation through suppression of p300-stimulated coactivation in 3T3-L1 cells PMID: 25446101

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KEGG: mmu:11910

STRING: 10090.ENSMUSP00000027941

UniGene: Mm.2706