Recombinant Mouse DNA (cytosine-5)-methyltransferase 3-like (Dnmt3l)

1. The Sirt1 protein suppressed transcription of Dnmt3l. PMID: 28228259
2. The Dnmt3l mutation greatly reduced DNA methylation levels at most retrotransposons, but its impact on their RNA abundance was limited in prospermatogonia. In Pld6 mutant germ cells, although only a few retrotransposons exhibited reduced DNA methylation, many showed increased expression at the RNA level. PMID: 28749988
3. Dnmt3l-KO donor cells may offer a more permissive epigenetic state that is beneficial for Nuclear transfer reprogramming PMID: 26159833
4. By interacting with TRIM28, DNMT3L can attract various enzymes to form a DNMT3L-induced repressive complex to remove active marks and add repressive marks to histone proteins. PMID: 24991018
5. Hypomethylation of highly methylated CpG islands was caused by the downregulation of Dnmt3L and Dnmt3a due to hepatitis B X-protein bound to their promoters. PMID: 24941955
6. DNMT3L is required to delicately balance the cycling and quiescence of spermatogonial progenitor cells PMID: 24850856
7. Study demonstrates that Dnmt3L interacts with the Polycomb PRC2 complex in competition with the DNA methyltransferases Dnmt3a and Dnmt3b to maintain low methylation levels at the Histone 3 H3K27me3 regions. PMID: 24074865
8. Data indicate that expression of Dnmt3a, Dnmt3b, Dnmt3L as well as maintenance Dnmt1o in oocytes and zygotes was not disrupted. PMID: 23866265
9. Reduced expression of DNMT3L in male germ cells, associated with haploinsufficiency of the paternal-effect gene Dnmt3L, results in abnormal hypomethylation of prenatal germline progenitor cells. PMID: 23159436
10. The maternal store of Dnmt3L is not involved in embryonic de novo methylation. PMID: 23293288
11. Dnmt3l is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review) PMID: 22671959
12. We observe evidence for a context-dependent contribution of Dnmt3l to set and maintain CpG and non-CpG methylation at distinct classes of repetitive elements and selected single copy genes PMID: 22761581
13. Data show in DNMT3L-deficient germ cells at 16.5 dpc, average DNA methylation levels were about 30% of wildtype levels; however, by postnatal day 6, about half of the DNMT3L deficiency-specific hypomethylated loci had acquired normal methylation levels. PMID: 21949694
14. Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo. PMID: 21553025
15. show that both Dnmt3L(s) and Dnmt3L(o) produce full-length proteins but that the Dnmt3L(at) transcripts are not translated PMID: 21645502
16. The data demonstrate previously unrecognised roles for DNMT3L in late meiosis and in the transcriptional regulation of meiotic and post-meiotic germ cells. PMID: 21483837
17. CG dinucleotide recognized by the Dnmt3a and Dnmt3L complex are distinctive at retroelements and imprinted domains. PMID: 19921333
18. likely to function not directly as a DNA methyltransferase but as a regulator of methylation at imprinted loci PMID: 11719692
19. Dnmt3L is required for the establishment of methylation imprints in oocyte. Dnmt3L is required for spermatogenesis. PMID: 11934864
20. Loss of Dnmt3L from early germ cells caused meiotic failure in spermatocytes, which do not express Dnmt3L PMID: 15318244
21. Results suggest a model in which the interaction of Dnmt3A with Dnmt3L induces a conformational change of Dnmt3A that opens the active site of the enzyme and promotes binding of DNA and the AdoMet. PMID: 15671018
22. The Dnmt3l genes showing marginal correlation (-.4 < p(s) < .6) were present in the early stages of differentiation of both GD and RD, which were non-specific to brain development. PMID: 16627687
23. Dnmt3L is required for the establishment of maternal methylation imprints both in the embryos and the placentae PMID: 16920095
24. Dnmt3a2 recruits Dnmt3L to chromatin, and induces regional DNA methylation in germ cells. PMID: 16999741
25. Sex-specific promoters control Dnmt3L expression in the mouse germ line, mirroring the situation at the Dnmt1 and Dnmt3A loci. PMID: 17060371
26. dnmt3l is coordinately regulated and its expression peaks during the stage of postnatal oocyte development when maternal methylation imprints are established PMID: 17445268
27. Imprinted and repetitive sequences showed moderate to severe hypomethylation in Dnmt3L-deficient prospermatogonia, indicating the critical function and broad specificity of this factor in de novo methylation. PMID: 17616512
28. The main proteins that interact in vivo with the product of an epitope-tagged allele of the endogenous Dnmt3L gene were identified by mass spectrometry as DNMT3A2, DNMT3B and the four core histones PMID: 17687327
29. temporal expression study showed that expression of Dnmt3L is highest in prenatal gonocytes but is also detected and developmentally regulated during spermatogenesis PMID: 17875220
30. Insufficient methylation of the DNMT3L promoter during embryonic development due to deficiency in DNMT3B might be implicated in the pathogenesis of the ICF syndrome (characterized by immunodeficiency, centromere instability and facial anomalies). PMID: 18544626

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KEGG: mmu:54427

STRING: 10090.ENSMUSP00000000746

UniGene: Mm.13433