Recombinant Mouse Diencephalon/mesencephalon homeobox protein 1 (Dmbx1)

Code CSB-YP838713MO
MSDS
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP838713MO
MSDS
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP838713MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP838713MO
MSDS
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP838713MO
MSDS
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
Dmbx1
Uniprot No.
Alternative Names
Dmbx1; Cdmx; Mbx; Otx3; PaxBDiencephalon/mesencephalon homeobox protein 1; Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein; Orthodenticle homolog 3; Paired-like homeobox protein DMBX1; Paired-type homeobox Atx
Species
Mus musculus (Mouse)
Expression Region
1-381
Target Protein Sequence
MQHYGVNGYS LHAMNSLSAM YNLHQQAAQQ AQHAPDYRPS VHALTLAERL AGCTFQDIIL EARYGSQHRK QRRSRTAFTA QQLEALEKTF QKTHYPDVVM RERLAMCTNL PEARVQVWFK NRRAKFRKKQ RSLQKEQLQK QKEAEGSHGE GKVEAPASDT QLETEQPPGL PSGDPPAELQ LSLSEQSASE SAPEDQLDRE EDSRAEEPKA EKSPGSESKV PGCKRGSPKA DSPGSLAITP AAPGGGLLGP SHSYSSSPLS LFRLQEQFRQ HMAATNNLMH YSSFEVGGPA PAAAAAAAAA VPYLGVNMAP LSSLHCQSYY QSLSAAAAAH QGVWGSPLLP APPTGLAPAS AALNSKTTSI ENLRLRAKQH AASLGLDTLP N
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability.
Gene References into Functions
  1. The crystal structure of mouse ATX in complex with an anti-ATX aptamer. PMID: 27043297
  2. Data (including data from studies in transgenic/knockout mice) suggest that expression in adult brain neurons (especially in parabrachial nucleus) of both Dmbx1 and AgRP (agouti-related peptide) is important in appetite regulation leading to leanness. PMID: 26505115
  3. Dmbx1, a novel evolutionarily conserved paired-like homeobox gene is expressed in the brain of mouse embryos. Linkage analysis mapped mouse Dmbx1 to the mid-portion of chromosome 4. PMID: 11744391
  4. provides a useful molecular marker for early mouse midbrain development and may play a critical role in brain development PMID: 11914943
  5. results suggest that Otx3 is a novel member of the Otx family and may be involved in the development of the central nervous system PMID: 12055180
  6. Dmbx1 gene is expressed in the developing mouse diencephalon, midbrain and hindbrain, and has dynamic expression during forelimb and hindlimb development PMID: 12111214
  7. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum PMID: 12175514
  8. Dmbx1 is expressed only in the developing central nervous system and in particular during early determination and successive differentiation of the midbrain and caudal diencephalon PMID: 12175515
  9. Results demonstrate that Dmbx1 is required for postnatal survival, growth, and brain development. PMID: 15314164
  10. Otx3/Dmbx1 represses Otx2-mediated transcription in the developing brain PMID: 15890343
  11. Dmbx1 is essential for various actions of agouti-related protein and plays a role in normal regulation of energy homeostasis and behavior PMID: 17873059

Show More

Hide All

Subcellular Location
Nucleus.
Protein Families
Paired homeobox family
Tissue Specificity
Expressed in adult brain, stomach, and testis. Expressed in the developing diencephalon, midbrain and hindbrain. During limb development, expressed in a temporal pattern with expression being first restricted to the forelimbs and then subsequently to the
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1