Recombinant Mouse Disrupted in schizophrenia 1 homolog (Disc1), partial

1. DISC1 aggregates transfer between neuronal cells in co-culture. PMID: 28275106
2. The findings of this study suggested that DISC1 risk factors expressed in astrocytes could affect adult hippocampal neurogenesis and contribute to aspects of psychiatric disease through abnormal production of D-serine. PMID: 28631721
3. Mutant DISC1 revealed increased spontaneous firing of Purkinje cells and impaired cognitive and social behaviors. PMID: 28392471
4. This study shown the disc1 mutation and environment effect the neuronal activity, long-range synchrony and directed interactions within hippocampal-prefrontal networks are impaired at both developmental stages in mice. PMID: 27613435
5. the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative information processing and contribute to recognition deficits in DISC1 L100P mutant mice. PMID: 27729083
6. the 100P mutation in Disc1 prevents expression of parvalbumin by a normally sized cohort of interneurons and altering Disc1 function in cortical excitatory neurons indirectly affects parvalbumin expression by cortical interneurons, perhaps as a result of altered functional input from the excitatory neurons. PMID: 27244370
7. mutant DISC1 diminished the capacity of astrocytes to support dendritic and synaptic maturation in co-cultured neurons PMID: 27187935
8. abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice. PMID: 26497623
9. Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta signaling and sex-dependent behavioral effects in mice PMID: 26728762
10. Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function. PMID: 26756905
11. Hypoxic preconditioning decreases NF-kappaB activity via Disc1. PMID: 26615762
12. Results indicate that DISC1 attenuates Abeta generation and cognitive deficits of APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1 PMID: 26062786
13. These results suggest that alteration of CB1R-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors. PMID: 26093170
14. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition. PMID: 26546129
15. Study found that DISC1 influences APP C-terminal processing and Abeta peptide generation, affects surface expression and internalization of APP in neurons PMID: 25224257
16. DISC1 regulates the expression of brain neurotrophin VGF through the PI3K/AKT/CREB pathway. PMID: 26212236
17. Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate system dysfunction and altered brain connectivity. PMID: 25989143
18. DISC1 is a regulatory factor in ER calcium dynamics, linking a perturbed intracellular calcium signaling and schizophrenia pathogenesis. PMID: 25732993
19. DISC1 binds ITPR1 mRNA with HZF, thereby regulating its dendritic transport for synaptic plasticity. PMID: 25821909
20. Disc1 variation leads to specific alterations in adult neurogenesis. PMID: 25272038
21. The results of this study indicated that decreased D-serine production by astrocytic mutant DISC1 might lead to compensatory changes in levels of the amino acid transporters and NMDA receptors in the context of tripartite synapse. PMID: 25131692
22. DISC1 expression was detected in oligodendrocytes of the mouse corpus callosum at P14 and P70. the number of oligodendrocytes with a mature morphology were increased following knockdown of endogenous DISC1 by RNA interference. PMID: 24516667
23. Review describes functional roles of DISC1 and its molecular complexes in the brain and DISC1-associated mental disorders in the context of DISC1 and its interacting proteins PMID: 25016072
24. discrepancy in behavioral phenotypes to the Disc1 L100P mutant mouse line existing among different research groups needs to be cautiously investigated PMID: 25487992
25. expression levels of DA receptor mRNA were upregulated in the NAc of female Disc1(Delta2-3/Delta2-3) mice. Male Disc1(Delta2-3/Delta2-3) mice showed no apparent differences in all experiments PMID: 24973713
26. DISC1 truncation produces pathway-specific effects on long-term synaptic plasticity. PMID: 24712988
27. The FVB/NJ, SJL/J and SWR/J strains in the 'Swiss mice' category and DDY/JclSidSeyFrkJ in the 'China and Japan' category are homozygous for the Disc1del allele, while ICR/HaJ in the 'Swiss mice' category is homozygous for wild-type Disc1. PMID: 23563120
28. DISC1 participates in interneuron development. PMID: 23631734
29. Disc1 mutation differentially alters growth of axons, neurites and dendritic spines in cltured hippocampal and cortical neurons. PMID: 23396153
30. dominant-negative mutant DISC1 transgenic model showed augmented binding of radioligands to the dopamine D2 receptor (D2R) in the striatum as well as neurochemical and behavioral changes to methamphetamine administration PMID: 23314019
31. Disrupted-In-Schizophrenia-1 (DISC1) is a susceptibility gene for schizophrenia and other psychiatric disorders; Lcn2 is a potential novel drug target for early intervention in schizophrenia PMID: 23272119
32. Data suggest that further behavioral studies are necessary to determine whether Disc1 mutant lines are suitable animal models of schizophrenia and major depression. PMID: 22348257
33. both initial exploratory and habituation of exploration are impaired in a novel open field environment with mutation of DISC1. PMID: 22388794
34. DISC1-Q31L mutants showed increased sensitivity to GSK-3 inhibitor compared to DISC1-L100P mice. PMID: 21376063
35. DISC1 enhances organelle transport in synaptic vesicles along microtubules via a lithium-sensitive pathway that could be therapeutically targeted for treatment of neuropsychiatric diseases. PMID: 21664390
36. Study uncovers an interplay between intrinsic DISC1 and extrinsic GABA signaling, two schizophrenia susceptibility pathways. PMID: 22385968
37. Data show that cAMP levels are elevated as a result of the Disc1 mutation, leading to altered axonal targeting and dendritic growth. PMID: 22049344
38. DISC1 is necessary in mice for the migration of the cortical interneurons generated in the medial ganglionic eminence. PMID: 22238109
39. The Disc1 mutant mice displayed abnormal emotional behavior as assessed by the elevated plus-maze and cliff-avoidance tests. PMID: 21903668
40. Study provides evidence that the DISC1-TNIK interaction regulates synaptic composition and activity by stabilizing the levels of key postsynaptic density proteins. DISC1 appears to be a key cellular brake for TNIK activity. PMID: 20838393
41. DISC1 and fasciculation and elongation protein (Fez)zeta-1 regulate cell positioning and morphogenesis of newborn neurons in hippocampus. PMID: 22099459
42. Neurite outgrowth and spine development abnormalities induced by Disc1 mutation were partially corrected through GSK3alpha inactivation. PMID: 21498050
43. Disc1 is required for migration and layer formation by the CA1 pyramidal neurons during hippocampal development. PMID: 21540240
44. This study demonstrated that there is a DISC1-dependant mechanism for regulating neurexin gene expression in mice. PMID: 21321563
45. The TRIO-RAC-PAK signaling pathway can be exploited and modulated by DISC1 to regulate axonal connectivity in the developing brain. PMID: 21422296
46. Synaptic levels of DISC1 are regulated by NMDA receptor function. PMID: 21436042
47. relating genetic variation in the DISC1 pathway to functional and structural studies of the brain in humans and in the mouse [Review] PMID: 21149852
48. Disc1 mutant mice with point mutations (Q31L and L100P) have a relative reduction in neuron number, decreased neurogenesis, and altered neuron distribution compared to wild-type littermates. PMID: 21368031
49. a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch PMID: 21471969
50. Our data provide genetic, biochemical, and behavioral evidence for a molecular link between DISC1 and GSK-3 in relation to psychopathology PMID: 20687111

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KEGG: mmu:244667

STRING: 10090.ENSMUSP00000095914

UniGene: Mm.233504