Recombinant Mouse Equilibrative nucleoside transporter 1 (Slc29a1), partial

1. Chronic inhibition of ENT1 or by genetic removal of ENT1 enhanced the survival of R6/2 mice. Collectively, adenosine homeostasis and ENT1 expression are altered in Huntington's disease (HD). The inhibition of ENT1 can enhance extracellular adenosine level and be a potential therapeutic approach for treating HD. PMID: 28069792
2. Study suggests that during sleep-wakefulness, type 1 equilibrative nucleoside transporter is necessary for the linear relationship between EEG markers of waking and the following periods of NREMS, and the adenosine is critical for this regulation. PMID: 26143012
3. ENBT1 activity is decreased in MVEC in response to the increased superoxide radical that is associated with ischemia/reperfusion injury PMID: 25448155
4. results establish Augustine as a new blood group system and place SLC29A1 as a new candidate gene for idiopathic disorders characterized with ectopic calcification/mineralization. PMID: 25896650
5. Findings demonstrate that ENT1 regulates GFAP expression and possibly astrocyte function PMID: 25365803
6. ENT1-regulated adenosine signaling plays an essential role in lumbar spine and femur bone density PMID: 24586402
7. findings implicate ENT1 in liver protection from ischemia and reperfusion injury and suggest ENT inhibitors may be of benefit in the prevention or treatment of ischemic liver injury PMID: 23703920
8. This is the first report of a role for ENT1 in regulating the calcification of soft tissues. ENT1(-/-) mice may be a useful model for investigating pathogenesis and evaluating therapeutics for the prevention of mineralization in DISH and related disord PMID: 23184610
9. these findings reveal the transcriptional repression of ENT1,2 as an innate protective response during acute pulmonary inflammation. PMID: 23590299
10. It was shown that the responsiveness of kidney tubules and glomeruli is significantly attenuated in the absence of ENT1, leading to changes of extracellular adenosine levels in the juxtaglomerular apparatus interstitium. PMID: 23269643
11. This study demonstrated that the A2AR antagonist ZM241385 dampened protein kinase A activity-mediated signaling in the DMS and promoted excessive ethanol drinking in ENT1(+/+) mice PMID: 23467349
12. Perfusions without sodium drastically reduced the intestinal loss of ribavirin in both wild-type and Ent1(-/-) mice. PMID: 22812541
13. Mice lacking ENT1 exhibit increased glutamate levels in the nucleus accumbens as well as increased ethanol drinking behaviors. PMID: 21172405
14. ENT1-null mice possess elevated circulating adenosine levels and reduced cellular uptake resulting in a perpetually cardioprotected phenotype. PMID: 21872611
15. ENT1 regulates NMDA glutamate receptor-mediated signaling in the nucleus accumbens, which provides a molecular basis that underlies the ethanol-preferring behavior of ENT1 knockout mice. PMID: 21489406
16. Data suggest that a unified change in nucleoside transporter (NT) gene expression is not required for the normal development and functioning of the ENT1 knockout mice. PMID: 21455274
17. activation of JNK-cJun pathway negatively regulates mENT1 and suggest that this mechanism might contribute to the development of nucleoside analog-derived drug resistance. PMID: 21145879
18. ENT1 regulates glutamate uptake activity by altering EAAT2 expression and function, which might be implicated in ethanol intoxication and preference. PMID: 20374202
19. Nucleoside transporters are important mediators of (18)F-FLT uptake in normal and transformed cells. PMID: 20720035
20. Our results suggest that adenosine-regulated glutamatergic signaling contributes to a reduced level of alcohol response. PMID: 20085785
21. ENT1 plays an essential role in cardioprotection, most likely due to its effects in modulating purine nucleoside-dependent signaling. The ENT1-null mouse is a powerful model system for the study of the role of ENTs in the physiology of the cardiomyocyte. PMID: 20035027
22. PKC delta/epsilon-dependent stimulation of hENT1 transport by a mechanism that may involve activation of transporters at the membrane possibly by post-translational modification of the protein. PMID: 12062437
23. hENT1 and hENT2 expression was significantly retained in a high percentage of tumors (91% and 96% for hENT1, 84% and 98% for hENT2, in ovarian and cervix carcinomas, respectively). PMID: 15386342
24. Astrocytes are accordingly well suited for both intense nucleoside metabolism and metabolism-independent uptake to terminate neuromodulator effects of adenosine and guanosine. PMID: 15892125
25. analysis of interspecies differences in the mitochondrial targeting signal of the equilibrative nucleoside transporter 1 PMID: 16595656
26. Type 1 equilibrative nucleoside null mice spent more time in the center of an open field, entered more frequently into and spent more time exploring the open arms of a plus maze, and spent more time exploring the light side of a light-dark box. PMID: 17376149
27. inhibition of CK2 activity, or deletion of Ser(254) from mENT1, enhances transporter affinity for the inhibitor, NBMPR, and reduces the number of ENT1 proteins functioning at the level of the plasma membrane PMID: 17520485
28. mENT1delta11, a novel altrnative splice variant of ENT1, is characterized. PMID: 18413666
29. Ent1(+/+) and Ent1(-/-) mice will serve as excellent models to investigate the contribution of Ent1 to the pharmacokinetics and toxicity of ribavirin PMID: 19164463
30. Ent1 plays a significant role in the oral absorption and erythrocyte distribution of ribavirin. PMID: 19602549

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KEGG: mmu:63959

STRING: 10090.ENSMUSP00000063096

UniGene: Mm.29744