Recombinant Mouse Forkhead box protein C1 (Foxc1)

1. Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program driven by FOXC1. PMID: 29959321
2. These findings suggest that Foxc1 is an important regulator to further chondrogenesis and initiate the ossification of the presphenoid and basisphenoid bones. PMID: 29322554
3. Lineage tracing experiments in Foxc1 mutant mouse cerebella indicate that aberrant migration of granule cell progenitors destined to form the posterior-most lobule causes this cerebellar malformation phenotype. PMID: 28092268
4. Foxc1 regulates both early cardiomyogenesis and the functional properties of embryonic stem cell-derived cardiomyocytes. PMID: 26824887
5. FOXC1 and FOXC2 are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases PMID: 27214551
6. These data indicate that Foxc1 expression is regulated by BMP4 and FOXC1 functions in the commitment of progenitor cells to the osteoblast fate and its expression is reduced when differentiation proceeds. PMID: 26666591
7. Foxc1 regulates sweat duct luminal cell differentiation and mimic apocrine miliaria. PMID: 27592801
8. Compound, NC-specific Foxc1; Foxc2 homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2, and its downstream effector Dkk2, which antagonizes canonical Wnt signaling. PMID: 28253399
9. These findings offer the first evidence for a role of the meninges in brain vascular development and provide new insight into potential causes of cerebrovascular defects in patients with FOXC1 mutations. PMID: 27671872
10. Foxc1 and Foxc2 maintain glomerular podocyte integrity by regulating the gene expression. PMID: 28223138
11. Foxc1 and Foxc2 have a role in kidney and axial skeleton development. PMID: 27193493
12. FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.FOXC1 is necessary to establish a multiple-bulge hair follicle architecture. PMID: 26912458
13. deletion of Foxc1 and Foxc2 specifically in Pax3-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb PMID: 26839363
14. Foxc1 is an important transcriptional partner of Ihh-Gli2 signalling during endochondral ossification, and that disruption of the Foxc1-Gli2 interaction causes skeletal abnormalities observed in the Axenfeld-Rieger syndrome. PMID: 25808752
15. In self-renewing stem cells (SCs), Foxc1 activates Nfatc1 and bone morphogenetic protein (BMP) signaling, two key mechanisms that govern quiescence. These findings reveal a dynamic, cell-intrinsic mechanism used by hair follicle SCs to reinforce quiescence upon self-renewal and suggest a unique ability of SCs to maintain cell identity. PMID: 26912704
16. These observations reveal an essential role for Foxc1 in the early stage of vascular formation in the telencephalon. PMID: 25733312
17. loss of Foxc1 non-autonomously induces a rapid and devastating decrease in embryonic cerebellar ventricular zone radial glial proliferation and concurrent increase in cerebellar neuronal differentiation PMID: 25513817
18. A loss of Foxc1 function affects skull bone formation of the apical region. PMID: 24417671
19. Together our data demonstrates that Foxc1 - Fgf8 signaling regulates mammalian jaw patterning and provides a mechanistic basis for the pathogenesis of syngnathia. PMID: 24385915
20. identification of Foxc1 as a specific transcriptional regulator essential for development and maintenance of the mesenchymal niches for haematopoietic stem and progenitor cells PMID: 24590069
21. FOXC1 is unnecessary for mammary morphogenesis; role in basal-like breast cancer likely involves processes that are unrelated to cell lineage specification. PMID: 23677979
22. Upper pole kidneys of newborn Foxc1(ch/ch) mice were significantly more hypoplastic and contained significantly fewer glomeruli than their lower pole counterparts. PMID: 23838094
23. These data indicate that Foxc1 expression leads to a similar enhanced osteogenic differentiation phenotype as observed with Msx2 overexpression PMID: 23145080
24. Foxc1 sets a threshold for the Bmp-dependent activation of Msx2, thus controlling the differentiation of osteogenic precursor cells and the rate and pattern of calvarial bone development. PMID: 23344708
25. A territorial correlation is identified between meningeal defects and disruption of interneuron migration along the adjacent marginal zone in the cerebral cortex of Foxc1-deficient mice. PMID: 22248045
26. These findings identify a role for FoxC1 in inhibiting corneal angiogenesis. PMID: 22171010
27. These data provide evidence that the Foxf2 gene, separated from Foxc1 by less than 70 kb of genomic sequence (250 kb in human DNA), may explain human abnormalities in some cases of ASD where FOXC1 has been excluded genetically. PMID: 22022403
28. Cortical dysplasia resembling cobblestone cortex, with basement membrane breakdown and lamination defects, is seen in Foxc1 mutants PMID: 20976766
29. Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. PMID: 14512019
30. FGF2 regulates the expression of Foxc1, indicating that Foxc1 integrates Bmp and Fgf signalling pathways PMID: 15906377
31. alongside its previously known roles in kidney, cardiovascular and eye development, Foxc1 has essential functions during at least two stages of gonad development-germ cell migration and folliculogenesis PMID: 16412416
32. Foxc1 mediates the bone morphogenetic protein signaling required for lacrimal gland development. PMID: 16470615
33. Results demonstrate that Foxc1 and 2 transcription factors are novel regulators of arterial cell specification upstream of Notch signaling and lymphatic sprouting during embryonic development. PMID: 16678147
34. Analysis of the regulation of Tgf beta1i4 by Foxc1 in mesenchymal cells isolated from the periocular region revealed that Foxc1 negatively regulated Tgf beta1i4 expression, presumably via secreted factors such as TGF-beta1. PMID: 16759280
35. Foxc1 is required for the development of the second heart field where the outflow tract, right ventricle, and part of the atrium and inflow tract are derived from a second cell lineage encompassing the secondary heart field. PMID: 16839542
36. defects in meningeal differentiation caused by mutations in Foxc1 can lead to severe cortical dysplasia. PMID: 17715063
37. These results provide novel evidence that Foxc transcription factors are important regulators of the chemotactic motility of endothelial cells through the induction of CXCR4 expression. PMID: 18187037

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KEGG: mmu:17300

STRING: 10090.ENSMUSP00000052196

UniGene: Mm.12949