Recombinant Mouse Forkhead box protein N1 (Foxn1)

1. Study report the identification of a highly conserved Foxn1-binding sequence that is located proximal to the beta5t-coding sequence in the mouse genome. This cis-regulatory element is indeed essential for the optimal expression of beta5t in cortical thymic epithelial cells and the optimal production of CD8+ T cells. PMID: 28176764
2. data identify the transcription factor Foxn1 as a potential key epidermal regulator modifying both epidermal and dermal healing processes after cutaneous wounding PMID: 28371152
3. MicroRNA-205 maintains T cell development following stress by regulating Foxn1 and its two regulated targets, stem cell factor and ccl25, following stress. PMID: 27646003
4. results show that Foxn1, and alleles under its control, are expressed in the pre-meiotic male germline, revealing a new tool for germline targeting of genes, and raising important concerns for gender selection when using Foxn1 regulatory elements. PMID: 27880796
5. this study shows that critical events in thymic lympho-stromal cross-talk and T cell selection are regulated by Foxn1 PMID: 27548434
6. sphingolipids and fatty acids associated with a decrease in glycerolipids suggest that the lipidome in mice skin is regulated by the Foxn1 gene PMID: 26427556
7. Foxn1 transcription factor regulates wound healing of skin through promoting epithelial-mesenchymal transition. PMID: 26938103
8. early differentiation and maturation of cortical and medullary thymic epithelial cells coincides with precise sub-lineage-specific regulation of Foxn1 expression levels. PMID: 26983083
9. upregulated expression in thymus epithelial cells upon challenges PMID: 26538393
10. Chromatin immunoprecipitation assay using RarB as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 and Foxn1 in mice. PMID: 26352270
11. The maturation and distribution of thymic epithelial cells in the Foxn1(-/-) thymic rudiment and the thymopoiesis of this newly developed rudiment, were examined. PMID: 24561455
12. Expression of FoxN1 in early life adversely influence immature epithelial cells T and B cell, and skin epithelial development. PMID: 25299782
13. this study presents the characterization of the adult thymic epithelial stem cells and demonstrates the dispensability of FoxN1 function for their stemness. PMID: 25148026
14. Enforced Foxn1 expression is sufficient to reprogramme fibroblasts into functional thymic epithelial cells. PMID: 25150981
15. TAp63 levels are positively correlated with TEC senescence but inversely correlated with expression of FoxN1 and FoxN1-regulated thymic epithelial cell differentiation. PMID: 24263106
16. Upregulation of a single transcription factor can substantially reverse age-related thymic involution, identifying FOXN1 as a specific target for improving thymus function. PMID: 24715454
17. The similar characteristics between IL-22 and Foxn1 leads to a speculation that Foxn1 is probably involved in thymic regeneration driven by IL-22. PMID: 24333537
18. skews multipotent progenitors development toward T lineage PMID: 24184560
19. Increased Foxn1 expression is required for the thymic expansion observed in Rb family mutant mice. PMID: 23669396
20. Findings provide the first evidence that K14-mediated FoxN1 deletion causes changes in T-cell function that mimic those in aging during an immune response to challenge with an infectious agent. PMID: 22514652
21. regulation by Foxn1 of a suite of genes with diverse roles in thymus development and/or function, suggests it acts as a master regulator of the core thymic epithelial programme. PMID: 22072979
22. Manipulation of Foxn1 expression in the thymus ameliorates thymopoiesis in aged mice and offer a strategy to combat the age-associated decline in naive T-cell production and CD4 naive/memory ratios in the elderly. PMID: 21908422
23. Msx2 and Foxn1 regulate differentiation of the keratogenous zone, proliferation of distal nail matrix cells, and organization of the nail bed. PMID: 21387539
24. The findings provide new insights into FoxN1 regulation of 3D thymic epithelial morphogenesis and maintenance, the distinct impacts of FoxN1 in the K14 epithelial subset of the thymus and skin, and its postnatal requirement. PMID: 21109991
25. data support a regulatory model of keratinocyte differentiation in which HOXC13-dependent activation of Foxn1 is part of a regulatory cascade controlling the expression of hair and nail terminal differentiation markers PMID: 21191399
26. Data show that the capacity for positive and negative selection of both CD4 and CD8 SP thymocytes was reduced in Foxn1(Delta/Delta) mutants. PMID: 21079757
27. Foxn1 is the essential transcription factor regulating the differentiation of thymic epithelial cells PMID: 20823228
28. results support the notion that decline of a single epithelial cell-autonomous gene FoxN1 levels with age causes primary deterioration in thymic epithelial cells PMID: 20156205
29. Notch/CSL signaling plays a unique function in control of hair follicle differentiation by the underlying mesenchyme, with Wnt5a signaling and FoxN1 as mediators. PMID: 20634318
30. Postnatal ubiquitous deletion of FoxN1 caused dramatic thymic atrophy in 5 days PMID: 19955175
31. Foxn1 gene knockout associated with male odor in mice might be jointly affected by the level of inbreeding and immunodeficiency. PMID: 20019156
32. Results indicate that Foxn1 dependent epithelial development is essential for vascularization of the thymus anlagen. PMID: 19853842
33. Role of the nude gene in epithelial terminal differentiation PMID: 11841548
34. In Pax9 null mice, the thymic anlage develops as an ectopic polyp-like structure in the larynx. It expresses Whn/Foxn1, a marker of thymic epithelium. PMID: 11932925
35. Secreted Wnt glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial Foxn1 expression in both autocrine and paracrine fashions. PMID: 12379851
36. pattern-forming phenomenon that occurs in the skin of mutant mice with a defect in splicing of the Foxn1 gene PMID: 12893877
37. Foxn1(nu) mutated gene has effects beyond downregulating keratin expression, including changes in filaggrin expression, and is critical for normal onycholemmal differentiation PMID: 15610506
38. the nude mutation of Foxn1 in mice retards the early growth of development of muscle but not of the matrix tissue in limb muscles PMID: 15694130
39. foxn1 may be involved in directing lineage choices of multi-potential progenitor epithelial cells PMID: 15986478
40. Mechanisms and signaling pathways by which Foxn1 modulates keratinocyte differentiation in hair follicle and nail apparatus. Molecular and functional consequences of loss of function of Foxn1 protein in skin. Review. PMID: 16232301
41. Modulates stage-specific markers by modulating protein kinase C activity, providing control over the timing of steps in the keratinocyte differentiation program. PMID: 17459087
42. Gene targeting into the 3' untranlated region of the Foxn1 locus is an efficient method to express any gene of interest in thymus epithelial cells from the earliest stage of thymus organogenesis. PMID: 17577402
43. lack of thymopoiesis in Foxn1-deficient mice is caused by multiple functional defects PMID: 17683113
44. These results suggest that the phenotype of peripheral T cells in Foxn1Delta/Delta mutant mice is the result of atypical progenitor cells developing in an abnormal thymic microenvironment with a deficient TCR and IL7 signaling system. PMID: 18056358
45. Thymopoiesis in the Foxn1Delta/Delta adult thymus proceeds from CD117- atypical progenitors, while CD117+ DN1a cells are absent or blocked in their ability to differentiate to the T lineage. PMID: 18178831
46. an evolutionarily conserved role of BMP signaling in the maintenance of Foxn1 expression. PMID: 18832682
47. Foxn1 is required to maintain the postnatal thymus PMID: 18978204
48. Results position Msx2 and Foxn1 upstream of Notch1 within the hair matrix and demonstrate that together these factors play a pivotal role in hair inner root sheath, cortex and medulla differentiation. PMID: 19103190
49. FoxN1 expression per se is not a signature for the thymic lineage. FoxN1 expression, whereas necessary for thymic epithelium, development, is not sufficient for this process to occur. PMID: 19786540
50. may control important regulating genes of lympho-epithelial interactions PMID: 11500834

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KEGG: mmu:15218

STRING: 10090.ENSMUSP00000103929

UniGene: Mm.392151