Recombinant Mouse Friend leukemia integration 1 transcription factor (Fli1)

1. Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130. PMID: 29038846
2. These results provide the first evidences that Fli-1 positively regulates LPS-induced IL-27 production in macrophages PMID: 26900987
3. protective against nephritis MRL/lpr mice PMID: 26538397
4. Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review) PMID: 26055516
5. The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 and FLI1. PMID: 26093983
6. It is a predisposing factor of systemic sclerosis. (review) PMID: 25748132
7. bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts PMID: 24708674
8. FLI1 and GATA2 are upstream regulators of SMAD1 and SMAD5 expression in endothelial cells. PMID: 25870111
9. These results demonstrate that Fli-1 is a novel regulator of the proinflammatory chemokine MCP-1. PMID: 25108845
10. Fli-1 directly increases the expression of IL-6 via promoter region binding. This represents one possible mechanism for the protective effect of decreased Fli-1 expression in lupus. PMID: 25155007
11. reducing FLI1 in lupus decreases the pathogenicity of T cells by decreasing TCR-specific activation and IL-4 production in part through the modulation of glycosphingolipid metabolism PMID: 24040398
12. Fli-1 is a novel and critical regulator of proinflammatory chemokines and affects the pathogenesis of disease through the regulation of factors that recruit inflammatory cells to sites of inflammation. PMID: 25098295
13. Fli-1 plays a critical role in both the DN2 to DN3 transition and alphabeta/gammadelta lineage commitment. PMID: 24935715
14. protein expression regulates the infiltration of inflammatory cells into the kidneys in lupus nephritis model PMID: 24580413
15. Demonstrate an important role for Flii in the development and regulation of the epidermal barrier, which may contribute to the impaired healing and skin fragility of epidermolysis bullosa patients. PMID: 24375017
16. Fli-1 plays an important role in the mononuclear phagocyte development, and the C-terminal transcriptional activation domain of Fli-1 negatively modulates mononuclear phagocyte development. PMID: 23320737
17. Spi-1, Fli-1 and Fli-3 (miR-17-92) oncogenes contribute to a single oncogenic network controlling cell proliferation in friend erythroleukemia. PMID: 23056458
18. Fli-1 impacts glomerulonephritis development by regulating expression of inflammatory chemokine MCP-1 and inflammatory cell infiltration in the kidneys in NZM2410 mice PMID: 23108091
19. IL-6 stimulation results via JAK2, Fli1, and Dnmt1 in down-regulation of Lox expression by epigenetic CpG methylation revealing a new mechanism negatively affecting bone matrix formation. PMID: 21148317
20. Expression of Fli-1 plays an important role in lupus nephritis disease development in NZM2410 mice. PMID: 20731671
21. Fli-1 controls several lineages commitment decisions at the stem cell, megakaryocytic-erythrocytic progenitors , and granulocytic-monocytic progenitor levels. PMID: 20733157
22. persistently reduced levels of Fli1 in endothelial cells may play a critical role in the development of SSc vasculopathy PMID: 20228226
23. hemostatic defect associated with the loss of a specific functional domain of the transcription factor Fli1 and previously unknown in vivo roles in megakaryocytic cell differentiation PMID: 20823267
24. evidence suggests that SHIP-1 is a direct Fli-1 target, SHIP-1 and Fli-1 regulate each other in a negative feedback loop, and the suppression of SHIP-1 by Fli-1 plays an important role in the transformation of erythroid progenitors by F-MuLV PMID: 20445019
25. Wild-type MRL/lpr receiving BM from Fli-1(+/-) MRL/lpr mice had statistically significantly lower autoantibodies, less proteinuria, reduced renal disease & prolonged survival compared to mice receiving BM from WT MRL/lpr mice. PMID: 20015093
26. Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene PMID: 20400501
27. The mouse Fli1 and human (FLIL) genes are similarly regulated by Ets factors in T cells. PMID: 19829305
28. Analysis of Fli1 expression in wounded and Leishmania major-infected skin and naive and infected lymph nodes validated the importance of Fli1 in lesion resolution and wound healing. PMID: 20368343
29. FLI-1 has a role in mesodermal cell differentiation PMID: 12509448
30. the ability of FLI-1 to inhibit erythropoietin-induced differentiation of erythroblasts and to confer enhanced cell survival in the absence of erythropoietin critically depend upon FLI-1 transcriptional activation properties PMID: 14570912
31. dysregulated expression of spi-1/pu.1 and fli-1 oncogenes is involved in murine erythroleukemia cell differentiation arrest PMID: 14647452
32. previously unknown physiologic roles for Fli-1 in granulocytic, erythroid, and NK cell proliferation and differentiation PMID: 15367440
33. Modulation of Fli-1 expression profoundly decreases lupus-like disease and improves survival in MRL/lpr mice. PMID: 15528390
34. Fli-1 overexpression involved in indirect control of p53 and capable of leading to an increasingly aggressive erythroleukemia clone in vivo PMID: 15592502
35. Fli-1 modulates B cell development both centrally and peripherally, resulting in a significant impact on the in vivo immune response PMID: 18641300
36. results demonstrate that Fli-1 deficiency affects B cell proliferative responses to mitogens, independent of BCR and TLR expression PMID: 18692443
37. results establish Fli1 as a key regulator of the collagen homeostasis in the skin in vivo PMID: 19001092
38. Results suggest that the oncogenicity of Spi-1, Fli-1, and possibly other ETS transcription factors may involve their ability to stimulate ribosome biogenesis. PMID: 19289502
39. Results suggest that dephosphorylation of FLI-1 is a key event in the transcriptional regulation of megakaryocyte maturation. PMID: 19470763

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KEGG: mmu:14247

STRING: 10090.ENSMUSP00000016231

UniGene: Mm.258908