Recombinant Mouse GATA-type zinc finger protein 1 (Zglp1)

Code CSB-YP632278MO
MSDS
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Source Yeast
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Code CSB-EP632278MO
MSDS
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Source E.coli
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Code CSB-EP632278MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP632278MO
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP632278MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Zglp1
Uniprot No.
Alternative Names
Zglp1; Glp1; GATA-type zinc finger protein 1; GATA-like protein 1; GLP-1
Species
Mus musculus (Mouse)
Expression Region
1-266
Target Protein Sequence
MEAAQAGDLT RRQELLAPPC LDTESLRKSR PPALEPGALR CLTPNIRSLW PTCQDSVSTA LPFLQEKEKG LPGSPSPATQ VLGSCWELMV IGMSDHLSMA RNPRGTQCPN LEISSATSPA SLQRRPRKQL NPRMGIEKVD PRFKGVTLEF QIQPDSSLQI VPTYSLPGRS CSQKLPASPS KALASPGSSE ALGPRRCASC RTQRTPLWRD AEDGTPLCNA CGIRYKKYGT RCSSCWLVPR KSIQPKRLCG RCGMSQDPHL SPTQEL
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independently of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase.
Gene References into Functions
  1. study provides a comprehensive multi-level (circuit, synaptic, and molecular) explanation of how food intake behavior and body weight are regulated by endogenous central GLP-1. PMID: 29056294
  2. data demonstrate an increase in number of pro-alpha cells and activation of the intra-islet GLP-1 system comprise a self-defense mechanism for enhancing beta cell survival to combat lipid overload, which is in part mediated by oxidative stress and inflammation. PMID: 25976560
  3. Findings indicate an essential role for VAMP2 in GLP-1 exocytosis from the GLUTag L cell in response to a variety of established secretagogues. PMID: 24356748
  4. GLP-1 and analogues may provide neuroprotective actions in ALS PMID: 22384126
  5. Loss of GLP-1 is associated with germ cell development during embryonic oogenesis. PMID: 21123517
  6. data identify GLP-1 as a critical nuclear repressor in somatic cells of the gonad that is required for germ cell development, and highlight the importance of somatic-germ cell interactions in the regulation of this critical process PMID: 16982049

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Subcellular Location
Nucleus.
Tissue Specificity
Specifically expressed in adult testis and ovary. Expressed at high levels in the somatic cells of the developing gonads, including Leydig cells in the testes and granulosa cells in the ovaries.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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