Recombinant Mouse Grainyhead-like protein 3 homolog (Grhl3)

1. Diminished Grhl3 expression in the hindgut is the cause of spinal NTDs in the curly tail, carrying a hypomorphic Grhl3 allele. Complete loss of Grhl3 produces a more severe phenotype in which closure fails earlier in neurulation, before onset of expression in the hindgut of wild-type embryos. Abnormal surface ectoderm function, where Grhl3 mRNA is first detected, is responsible for early spinal neurulation failure. PMID: 29397878
2. This study demonstrated that Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice. PMID: 27907249
3. Findings suggest that transcription factor Grainyhead-like 3 (Grhl3) may be involved in the developmental pathogenesis of craniosynostosis. PMID: 27756203
4. Based on the results, it proposes that developmental stage-specific Grhl3 plays a significant role in circumvallate papilla (CVP) morphogenesis not by just disruption of epithelial integrity but by regulating epithelial cell proliferation, apoptosis, and migration via Shh, Wnt, and apoptosis signaling during mouse embryogenesis. PMID: 27586853
5. Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis. PMID: 25658689
6. This study identifies a GRHL3-regulated epidermal barrier repair pathway that suppresses disease initiation and helps resolve existing lesions in immune-mediated epidermal hyperplasia. PMID: 25347468
7. decreased Grhl3 expression contributes to tumor progression and upregulation of the oncomir miR-21 in squamous cell carcinoma of the skin. PMID: 22614019
8. The developmental transcription factor Grhl3 is a potent tumor suppressor of squamous cell carcinoma in mice. PMID: 22094257
9. Both GRHL2 and GRHL3 bind to and regulate expression of the wound repair gene Rho GEF 19, but regulation of the barrier forming gene, Transglutaminase 1 (TGase1), is unique to GRHL3. PMID: 21081122
10. maps to Chromosome 4, 135 Mb (66 cM) from the centromere, probably not Idb3, Wnt4, Cdc42, perlecan or Grhl-3 PMID: 15678492
11. Loss of Grhl3 alone defines a distinct lower spinal closure defect, also with defective dorso-lateral hinge points formation PMID: 20654612
12. folate deficiency caused a similar-sized, statistically significant increase in the frequency of exencephaly among both curly tail (Grhl3 mutant) embryos and background-matched embryos that are wild type for Grhl3. PMID: 19824061
13. formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3[Grhl3] PMID: 15831758
14. Unique role of Grhl3 in neurulation and epidermal morphogenesis. PMID: 16831572
15. These findings indicate that the Get-1 and LMO4 genes interact functionally to regulate epidermal terminal differentiation. PMID: 16949565
16. This study provides evidence for a critical role of diminished Grhl3 expression in causing spinal NTDs in the curly tail mouse model. PMID: 17720888
17. The failure of eyelid closure is due to critical functions of Get1 in promoting F-actin polymerization, filopodia formation, and the cell shape changes that are required for migration of the keratinocytes at the leading edge during eyelid closure. PMID: 18485343
18. Study demonstrates that the LIM-only domain protein, LMO4 serves as a functional partner of GRHL3 in its established roles, and define a new cooperative role for these factors in another developmental epidermal migration event, eyelid fusion. PMID: 18619436

Show More

Hide All

KEGG: mmu:230824

UniGene: Mm.331972