Recombinant Mouse Hairy/enhancer-of-split related with YRPW motif protein 2 (Hey2)

1. Results suggest that bone morphogenetic protein signaling plays pivotal roles in retinal progenitor cell differentiation into late differentiating retinal cell types and in Muller glia maturation; these effects were mediated, at least in part, by Hey2 PMID: 24890415
2. CHF1/Hey2 may contribute to Brugada syndrome. PMID: 24687990
3. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. PMID: 23872634
4. Data indicate that Hairy and Enhancer of Split-related with YRPW motif (HEY)2 decreases skeletal mass and regulates bone remodeling in male mice. PMID: 23782701
5. Survivor mice lacking the Hesr2 gene exhibit fibrosis in the aortic valve and ventricle in adulthood, thus suggesting that Hesr2 plays an important role in maintaining the homeostasis of the aortic valve and ventricle. PMID: 23288164
6. These findings support the hypothesis that CHF1/Hey2 is an important regulator of MMP10 expression. PMID: 22079635
7. Hey2 regulates the later steps of coronary vascular development in both a myocardial-dependent, non-cell autonomous fashion and likely a vascular cell-specific effect as well. PMID: 20619341
8. Data demonstrate that CHF1/Hey2 promotes physiological over pathological hypertrophy through suppression of apoptosis and regulation of multiple transcriptional pathways. PMID: 20001863
9. Hey2 loss does not affect aortic development, but it instead leads to a massive postnatal cardiac hypertrophy with high lethality during the first 10 days of life. PMID: 12372253
10. Homozygotes for the Hey2 mutant allele display a spectrum of cardiac malformations including ventricular septal defects, tetralogy of Fallot, and tricuspid atresia. PMID: 12372254
11. CHF1 plays an important role in regulation of ventricular septation in mammalian heart development and is important for normal myocardial contractility. PMID: 12454287
12. role in abrogating Runx2 transcriptional activity PMID: 15178686
13. hesr2 plays an important role in the formation of the tricuspid and mitral valves and in cardiomyocyte development. PMID: 15297376
14. Requirement for hesr2 in mediating Notch signaling in the developing cardiac and vascular systems. PMID: 15680351
15. Our findings suggest that CHF1/Hey2 suppresses atrial identity in the left ventricular compact myocardium, facilitates myocardial proliferation by suppressing Tbx5, and thereby promotes proper ventricular myocardial maturation. PMID: 17332425
16. a ventricular myocardial cell-autonomous function for Hrt2 in the suppression of atrial cell identity and the maintenance of postnatal cardiac function. PMID: 17468400
17. activation of the Dll4 and Hey2 promoters is induced by VEGF in conjunction with either Foxc1 or Foxc2 more than by either component alone PMID: 18545664
18. Data show that Notch signaling is not necessary for the differentiation and maintenance of pillar cell fate, that pillar cells are distinguished by Hey2 expression, and that-unlike other Hes/Hey factors-Hey2 expression is Notch independent. PMID: 19154718

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KEGG: mmu:15214

STRING: 10090.ENSMUSP00000019924

UniGene: Mm.103573