Recombinant Mouse Hemojuvelin (Hfe2)

1. Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels PMID: 26944476
2. These data suggest that, in Hjv(-/-) females, Bmp6 can provide a signal adequate to maintain hepcidin to a level sufficient to avoid extrahepatic iron loading. PMID: 29021231
3. The results provide support for the interaction between TMPRSS6 and hemojuvelin in vivo; they also suggest that hemojuvelin could be cleaved by another as yet unknown protease in the absence of functional TMPRSS6. PMID: 29073189
4. Hjv (--) and Hfe (C282YC282Y) transgenic mice displayed enhanced colonization of deep tissues by Yersinia pseudotuberculosis following oral inoculation, recapitulating enhanced susceptibility of humans with hemochromatosis to disseminated infection with enteropathogenic Yersinia. PMID: 27446816
5. The data demonstrate that endothelial cells are the predominant source of BMP6 in the liver and support a model in which endothelial cells BMP6 has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin transcription and maintain systemic iron homeostasis. PMID: 27864295
6. The minor variant of the HJV polymorphic site rs16827043 is a significant factor associated with hypertension among 50 year-old individuals compared with the AA genotype carriers. For the other polymorphic variant rs7536827, association with hypertension was found only among normal or slightly overweight A-allele carriers. In conclusion, HJV genetic variants were associated with essential hypertension in Finnish subjects. PMID: 28151915
7. Results indicate that an efficient induction of hepcidin expression by hemojuvelin (HJV) requires its interaction with neogenin. PMID: 27072365
8. Single Hjv(-)/(-) and double Hfe(-)/(-)Hjv(-)/(-) mice exhibit comparable iron overload. Hfe and Hjv regulate hepcidin via the same pathway. PMID: 25609138
9. Results show that HFE may depend on HJV for hepcidin regulation. Residual hepcidin in the absence of HFE suggests either the presence of an unknown regulator synergistic with HJV or that HJV is sufficient to maintain basal levels of hepcidin. PMID: 25608116
10. Parenchymal hepatic iron overload does not suffice to trigger progression of liver steatosis to steatohepatitis or fibrosis in Hjv knockout C57BL/6 mice. PMID: 25501544
11. Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin. PMID: 24409331
12. Deletion of Hjv in mice leads to abnormal retinal angiogenesis/vasculogenesis, with proliferation of new, leaky blood vessels in the vitreous. PMID: 24812553
13. Loss of matriptase-2 increases bone morphogenetic protein-dependent signaling, while paradoxically decreasing liver hemojuvelin protein content. PMID: 23590607
14. Use of proteomic analysis enables identification of four disulfide linkages in hemojuvelin/repulsive guidance molecule C. This molecule is a single-chain HJV/RGMc isoform. PMID: 23464809
15. we conclude that TNF-alpha suppresses Hemojuvelin(HJV) transcription possibly via a novel TNFRE within the HJV promoter PMID: 22998440
16. high levels of serum s-HJV in CDA I patients, suggesting that it may contribute to iron loading pathology in CDA I and eventually in other anemias with ineffective erythropoiesis. PMID: 23095116
17. Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in conditions of iron overload. PMID: 21993681
18. membrane-associated HJV is necessary for BMP6-mediated activation of hepcidin promoter inretinal pigment epithelium (RPE) cells; results confirm the biological importance of HJV in the regulation of iron homoeostasis in the retina and in RPE PMID: 21943374
19. The hemochromatotic phenotype of liver-specific Hjv-/- mice suggests that hepatic Hjv is necessary and sufficient to regulate hepcidin expression and control systemic iron homeostasis. PMID: 21748766
20. The data do not provide support for the concept that matriptase-2 cleaves membrane hemojuvelin and may indicate that, in vivo, the role of matriptase-2 in the regulation of hepcidin gene expression is more complex. PMID: 21612955
21. different oligosaccharides are attached to liver and muscle HJV peptides PMID: 21936923
22. in spite of its expression pattern, hemojuvelin is primarily important in the liver. PMID: 21493799
23. conserved promoter elements control RGMc gene transcription during skeletal muscle differentiation. PMID: 20858542
24. Soluble hemojuvelin is not the sole factor responsible for hepcidin downregulation by chronic bleeding. PMID: 19249912
25. Hemojuvelin-mutant mice treated with erythropoietin had decreased Hamp mRNA, demonstrating that hemojuvelin is not an indispensable component in EPO-induced Hamp gene downregulation. PMID: 20219396
26. the regulation of hepatic BMP6 expression by iron is independent of HJV, and expression of HJV in hepatocytes plays an essential role in hepcidin expression by potentiating the BMP6-mediated signaling PMID: 20363739
27. Neogenin regulates iron homeostasis via inhibiting secretion of HJV, an inhibitor of bone morphogenetic protein (BMP) signaling, to enhance BMP signaling and hepcidin expression. PMID: 20065295
28. Exclusive expression in the muscle cell lineage. PMID: 14678836
29. Gene expression in livers of mice treated with iron, erythropoietin, or lipopolysaccharide (LPS), as well as during fetal and postnatal development. PMID: 15315977
30. HJV mRNA expression was detected in brain, liver, heart, lung, stomach, spleen, kidney, duodenum, jejunum, ileum, colon, skeletal muscle, testis and blood. Its role in regulating iron allocation could be extended to other tissues beyond the liver. PMID: 15590393
31. Rgmc regulation by LPS is Hfe-independent. PMID: 17255318
32. SOLUBLE hjv SUPPRESSES HEPCIDIN PRODUCTION IN HEPATOCYTES IN A DOSE-DEPENDENT MANNER PMID: 17869549
33. s-HJV originates from a furin cleavage at position 332-335 PMID: 17938254
34. The expression of HJV and other iron-regulatory proteins in retina during cytomegalovirus infection, was investigated. PMID: 19191760

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KEGG: mmu:69585

STRING: 10090.ENSMUSP00000046659

UniGene: Mm.171314