Recombinant Mouse Histone acetyltransferase KAT8 (Kat8)

1. MOF regulates male meiosis and is involved in the expansion of all three waves of H2AX phosphorylation from the leptotene to pachytene stages, initiated by ATM and ATR, respectively. PMID: 29795555
2. study demonstrated that HAT Mof is involved in the development of colitis, and the lack of Mof ameliorates DSS-induced colitis in mice. PMID: 29975939
3. This work identifies MOF as a key regulator of cellular stress response in glomerular podocytes. PMID: 26387537
4. demonstrate that KAT8 is essential for female fertility by regulating antioxidant gene expression and identify KAT8 as the first histone acetyltransferase with an essential function in oogenesis PMID: 28506985
5. MOF is a developmental-stage-specific chromatin regulator found to be essential for adult but not early fetal hematopoiesis. PMID: 27827827
6. MOF is a dual-transcriptional regulator of nuclear and mitochondrial genomes connecting epigenetics and metabolism. PMID: 27768893
7. complex provides additional, Tsix-independent repression of Xist by maintaining pluripotency PMID: 24842875
8. NSL and MSL HAT complexes differentially regulate specific sets of expressed genes in mESCs and during differentiation PMID: 24898753
9. cardiac-specific MOF overexpression protected mice from transverse aortic constriction-induced cardiac hypertrophy, with reduced radios of heart weight/body weight, decreased left ventricular wall thickness and increased fractional shortening. PMID: 24802406
10. Mof plays a critical role in T-cell differentiation and that depletion of Mof in T cells reduces T-cell numbers and, by an undefined mechanism, induces genomic instability in B cells through bystander mechanism. PMID: 23386701
11. Depletion of MOF in mouse embryonic stem cells causes a specific decrease in expression of a subset of X-linked genes. PMID: 23523075
12. the histone acetyltransferase Mof plays an essential role in the maintenance of ESC self-renewal and pluripotency PMID: 22862943
13. PHF20 is not required for maintaining the global H4K16 acetylation levels or locus specific histone acetylation but instead works downstream in transcriptional regulation of MOF target genes PMID: 22072714
14. Purkinje cells (PC)-specific deletion of the mouse males absent on the first (mMof) gene (Cre(-)), which encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac) and influences ATM function, is critical for PC longevity. PMID: 21321203
15. Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1. PMID: 21217699
16. Data show that loss of Mof leads to reduction of histone H4 K16 acetylation, cell cycle arrest, chromosome aberration, defects in DNA damage repair, and complete loss of Mdc1 response to DNA damage. PMID: 20837706
17. MOF is an essential factor for embryogenesis and oncogenesis PMID: 17967868
18. Mof is required specifically for the maintenance of histone4 lysine16 acetylation and normal chromatin architecture of all cells of early male and female embryos. PMID: 18541669
19. Data show that MOF acetylates TIP5, the largest subunit of NoRC, at a single lysine residue, K633, adjacent to the TIP5 RNA-binding domain, and that SIRT1 (removes the acetyl group from K633. PMID: 19578370

Show More

Hide All

KEGG: mmu:67773

STRING: 10090.ENSMUSP00000033070

UniGene: Mm.425492