Recombinant Mouse Homeobox protein DLX-5(Dlx5)

Code CSB-YP006956MO
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Source Yeast
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Code CSB-EP006956MO
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Source E.coli
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Code CSB-EP006956MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP006956MO
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Source Baculovirus
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Code CSB-MP006956MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Dlx5
Uniprot No. P70396
Alternative Names Dlx5Homeobox protein DLX-5
Species Mus musculus (Mouse)
Expression Region 1-289
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.
Gene References into Functions
  1. T-614 promotes osteoblastic differentiation by increasing the expression of Osterix and Dlx5. PMID: 29670900
  2. FGF10 pathway is downregulated in Dlx5(-/-) mice, and activation of FGF10 signaling rescues cranial neural crest cell proliferation and myogenic differentiation. PMID: 28982687
  3. High DLX5 expression is associated with T-cell lymphomagenesis. PMID: 28122332
  4. Both transient and stable expression of Necdin induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with distal-less Homeobox 5 (Dlx5) and Runx2 promoter activation. PMID: 28528976
  5. DLX5 and DLX6 reciprocally inhibit BMP/H2-mediated H1 enhancer regulation in mandible embryonic development. PMID: 27335460
  6. We found that in Dlx5;6 DKO limbs, the AER expresses lower levels of Wnt5a, shows scattered beta-catenin responsive cells and altered basolateral and planar cell polarity (PCP). PMID: 26685160
  7. Dlx5 and Dlx6 expression determines uterine architecture and adenogenesis and is needed for implantation PMID: 26512061
  8. The results presented here indicate that loss of Dlx5 causes a down-modulation of miR-9 and of miR-200-class, which results in the over-expression of the Foxg1 protein. PMID: 25937343
  9. Lck-Dlx5 mice develop T-ALLs that consistently acquire overexpression of Myc and activation of Akt. PMID: 25793663
  10. Study demonstrated a novel role of miR-124 and Dlx5 in regulating the differentiation of mesenchymal stem cells toward the myogenic lineage, that is, miR-124 inhibits myogenic differentiation partially through targeting Dlx5 expression. PMID: 24733577
  11. Mash1 is required for the expression of GAD67 and Dlx5 in taste bud cells. PMID: 24682237
  12. Results show that DLX5, p63, Pin1 and FGF8 participate to the same time- and location-restricted regulatory loop essential for apical ectodermal ridge stratification, hence for normal patterning and skeletal morphogenesis of the limb buds. PMID: 24569166
  13. The Edn1/Ednra signaling regulates neural crest differentiation to ensure the proper patterning of pharyngeal arch arteries, which is independent of the mechanism mediated by Dlx5/Dlx6. PMID: 23933587
  14. Data show that Dlx5 and Msx2 play a critical role in controlling cranial neural tube morphogenesis by regulating cell adhesion via the ephrinA5 and EphA7 pathway. PMID: 23425387
  15. in AER cells and, at later stages, in the limb mesoderm the regulation of by Dlx5 and Dlx6 occurs also cell autonomously PMID: 23382810
  16. allelic reduction of Dlx5 and Dlx6 in the mouse results in a POI-like phenotype, characterized by reduced fertility and early follicular exhaustion. PMID: 21505076
  17. These results suggest that Dlx5 is a novel target of Akt and that the activity of Dlx5 could be modulated by a novel mechanism involving Akt during osteoblast differentiation. PMID: 21619873
  18. Hand2 plays key role in lower jaw patterning in part by establishing negative-feedback loop in which Hand2 represses Dlx5 and Dlx6 expression in distal arch ectomesenchyme following Dlx5- and Dlx6-mediated induction of Hand2 expression in the same region PMID: 21558373
  19. These results suggest that PKA activity enhances the osteogenic function of Dlx5, at least in part, through protein stabilization and that BMP-2 regulates the osteogenic function of Dlx5, at least in part, through PKA. PMID: 21406180
  20. Identification of direct downstream targets of Dlx5 during early inner ear development. PMID: 21227998
  21. ectethmoid formation depends upon Dlx5 and Dlx6 expression in a restricted ectodermal territory of the anterior neural folds PMID: 21270050
  22. Msx1/Dlx5 interaction is crucial for osteogenic induction during frontal bone development. PMID: 20824629
  23. ultraconserved cis-regulatory element, I56i, is involved in regulating Dlx5/Dlx6 homeobox gene expression in the developing forebrain. PMID: 20702565
  24. We show that Edn1-dependent and -independent regulatory pathways act at different developmental times in distinct regions of pharyngeal arch (PA1) PMID: 20333701
  25. Dlx5 and 6 are necessary for head skeletogenesis, but also for the determination, differentiation, and patterning of cephalic myogenic mesoderm leading to masticatory muscle formation PMID: 20534536
  26. Ochratoxin A induces craniofacial malformation in mice acting on Dlx5 gene expression. PMID: 20036863
  27. Dlx5&6 appeared to be required for development and function of somal innervating (parvalbumin(+)) neocortical interneurons PMID: 20392955
  28. Dlx5 and Dlx6 are functionally equivalent in the endochondral skeleton PMID: 19956613
  29. Dlx5-regulated Fgf7 signaling inhibits the expression of Shh, which in turn controls the fate of CNC cells through tissue-tissue interaction and plays a crucial role during palatogenesis PMID: 19934017
  30. ectopic expression of Dlx5 induced the expression of glutamic acid decarboxylases (GADs) PMID: 11782417
  31. Dlx5 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. PMID: 12000792
  32. conclude that loss of Dlx5 and Dlx6 results in a homeotic transformation of the lower jaw into an upper jaw and that cellular identity within an arch relies on a nested pattern of Dlx expression PMID: 12193642
  33. simultaneous inactivation of the murine homeobox genes Dlx5 and Dlx6 results in the transformation of the lower jaw into an upper jaw and in symmetry of the snout PMID: 12434331
  34. DLX5 regulates development of peripheral and central components of the olfactory system PMID: 12533617
  35. In Dlx5(-/-) mice, the olfactory bulbs (OBs) lack glomeruli, exhibit disorganized cellular layers, and show reduced numbers of TH- and GAD67-positive neurons. Their axons fail to contact the OBs. PMID: 12727448
  36. Dlx5 is an indispensable regulator of BMP-2-induced osteoblast differentiation as well as the counteraction point of the opposing TGF-beta 1 action PMID: 12815054
  37. Dlx5 has roles during multiple stages of chondrocyte differentiation and is a general regulator of differentiation in the skeleton PMID: 12895028
  38. In this review, Dlx5 is a early bone morphogenetic protein 2 responsive gene in osteoblasts. PMID: 12957859
  39. Forced expression of Dlx5 in cultures of newborn mutant neural stem cells fully restores their neuronogenic potential, suggesting that Dlx5 is essential for secondary (postnatal) neuronogenesis. PMID: 14962748
  40. Dlx5 transactivates ALP expression, directly by binding to its cognate response element and/or indirectly by stimulating Runx2 expression, and Msx2 counteracts the direct transactivation of Dlx5 PMID: 15383550
  41. Mecp2 regulates Dlx5 by means of a silent chromatin loop PMID: 15608638
  42. skeletal phenotype of Msx1; Dlx5 double knock-out mice in relationship with their expression territories during craniofacial development PMID: 16330189
  43. Dlx5 homeobox gene is required for specification of the vestibule. PMID: 16900517
  44. investigated the domain requirements and transcriptional activities associated with Dlx5- and Dlx6-mediated chondrogenesis PMID: 17027239
  45. Three homeodomain proteins MSX2, DLX3, and DLX5 provide a key series of molecular switches that regulate expression of Runx2 throughout bone formation. PMID: 17060321
  46. These findings suggest that DNA methylation plays an important role in cell type-specific expression of Dlx5 and Osx. PMID: 17085970
  47. The studies presented here define a feed-forward transcriptional circuit between the MADS-box transcription factor MEF2C and the homeodomain transcription factors Dlx5 and Dlx6 in craniofacial development. PMID: 17420000
  48. Dlx5 is a positive regulator of chondrocyte maturation during endochondral ossification, in part by promoting the conversion of immature proliferating chondrocytes into hypertrophying chondrocytes. PMID: 17555518
  49. These data suggests that Dlx5 is not required to initiate migration and differentiation of migratory cells. PMID: 17588208
  50. Dlx5 overexpression and knock-down assays demonstrate its role in activating Osterix expression in response to BMP-2 PMID: 18056716
  51. Overexpression of RCAS-Dlx5RH inhibited mineralized nodule formation. Our results suggest that Dlx5 promotes expression of early markers of osteogenic differentiation and increases mineralization post-natally. PMID: 18096892
  52. Dlx5 and Dlx6 participate in the control of steroidogenesis during testis development. PMID: 18276760
  53. Dlx5 can act as an oncogene by cooperating with Akt2 to promote lymphomagenesis PMID: 18316591
  54. Regulation of Dlx5 gene expression by p63 is involved in EEC and SHFM congenital limb defects. PMID: 18326838
  55. Disruption in an Fgf3, -10/Dlx5 signaling cascade is operant in molecular mechanisms of inner ear teratogenesis by excess retinoic acid. PMID: 18412219
  56. Dlx5 is a central regulator of bone turnover PMID: 18669617
  57. TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development. PMID: 18684439
  58. The effect of Dlx5 allelic reduction in the control of bone remodeling, was analyzed. PMID: 19415689
  59. The MYC promoter is specifically activated by overexpression of DLX5. PMID: 19497851

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Subcellular Location Nucleus
Protein Families Distal-less homeobox family
Tissue Specificity Expressed in osteoblasts and chondrocytes.
Database Links

KEGG: mmu:13395

STRING: 10090.ENSMUSP00000052559

UniGene: Mm.4873

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