Product Details

Purity

>85% (SDS-PAGE)

Target Names

Otx1

Uniprot No.

P80205

Alternative Names

Otx1; Otx-1Homeobox protein OTX1; Orthodenticle homolog 1

Species

Mus musculus (Mouse)

Expression Region

1-355

Target Protein Sequence

MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG NGTKTRPVKK KSSPVRESSG SESSGQFTPP AVSSSASSSS SASSASANPA AAAAAGLGGN PVAAASSLST PTASSIWSPA SISPGSAPTS VSVPEPLAAP SNASCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPAPSS SYFGGVDCSS YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH HHQGYGGSGL AFNSADCLDY KEPAAAAASS AWKLNFNSPD CLDYKDQASW RFQVL

Protein Length

Full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Gene References into Functions

This study demonstrates that Otx1 is one of the key elements regulating cortical neurogenesis, and a loss-of-function in Otx1 may contribute to the overproduction of astrocytes in vivo. PMID: 29273633
Results indicate that the Otx1 expression is essential for the normal development of dendritic morphology, intrinsic electrophysiology and synaptic dynamics of motor cortex layer V pyramidal cells PMID: 25446351
the medial pallium requires Otx1 and Otx2 for its development later than E9.5, and the Otx2 expression in diencepalon and mesencephalon later than E9.5 is also directed by an enhancer other than FM1 and FM2 enhancers PMID: 20816794
GABAergic markers glutamic acid decarboxylase and parvalbumin were diminished in Otx1(-/-) cortex. The defects found in the cortical GABAergic system of these mice could explain the cortical hyperexcitability that produces seizures in these animals. PMID: 12435405
Reduction in Otx1 protein near the alar-basal plate boundary in midbrain results in a dorsal shift of Shh expression, and reduction in Otx1 protein at the midbrain-hindbrain boundary results in an anterior expansion of the Fgf8 domain. PMID: 12652306
a function for Otx1 in the regulation of blood cell production. PMID: 12934017
This study showed that the Otx1 gene has a more complex role and involved in the maturation and differentiation of various cerebral cortices, and, specifically, in the development of Ca-binding proteins (CaBP ).cells. PMID: 15147323
Otx1 is not crucial for the development of visual cortex identity but for the determination of the proportion of cortical areas to the whole neocortex in the mice. PMID: 18294714

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Subcellular Location

Nucleus.

Protein Families

Paired homeobox family, Bicoid subfamily

Tissue Specificity

Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.

Database Links

KEGG: mmu:18423

STRING: 10090.ENSMUSP00000006071

UniGene: Mm.129663

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Recombinant Mouse Homeobox protein OTX1 (Otx1)

Product Details

Customer Reviews and Q&A

Target Background

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