Recombinant Mouse Homeobox protein aristaless-like 3 (Alx3)

Code CSB-YP001646MO
MSDS
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Source Yeast
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Code CSB-EP001646MO
MSDS
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Source E.coli
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Code CSB-EP001646MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001646MO
MSDS
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Source Baculovirus
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Code CSB-MP001646MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Alx3
Uniprot No.
Alternative Names
Alx3Homeobox protein aristaless-like 3; Proline-rich transcription factor ALX3
Species
Mus musculus (Mouse)
Expression Region
1-343
Target Protein Sequence
MDPERCAPFS VGPAAGPYAA AGDEAPGPQG TPDAAPHLHP APPRGPRLSR FPACGPLEPY LPEPAKPPAK YLQDLGPGPV LNGGHFYEGS AEAEEKASKA ASFPQLPVDC RGGPRDGPSN VQASPGPCLA SLSVPLSPGL PDSMELAKTK SKKRRNRTTF STFQLEELEK VFQKTHYPDV YAREQLALRT DLTEARVQVW FQNRRAKWRK RERYGKMQEG RNPFTTAYDI SVLPRTDSHP QLQNSLWPSP GSGSPGGPCL MSPEGIPSPC MSPYSHSHGN VAGFMGVPAS PAAHPGIYSI HGFPPALGGH SFEPSPDGDY KSPSLVSLRM KPKEPPGLLN WTT
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Transcriptional regulator with a possible role in patterning of mesoderm during development.
Gene References into Functions
  1. Study shows that ALX3 deficiency provides a novel molecular mechanism for developmental defects arising from maternal hyperglycaemia. PMID: 28341857
  2. results indicate that Alx3 expression is enhanced by BMP-2 via the BMP receptors mediated-Smad signaling and that Alx3 is a positive regulator of osteoblast differentiation induced by BMP-2 PMID: 23825702
  3. Glucose-stimulated expression of ALX3 in alpha cells provides a regulatory mechanism for the downregulation of glucagon gene expression by interfering with PAX6-mediated transactivation on the glucagon G1 promoter element. PMID: 26739814
  4. Pdx1, USF1 and USF2 co-ordinately regulate Alx3 gene expression in pancreatic beta-cells. PMID: 25040025
  5. Alx3 promoter activity in mesenchymal and pancreatic cells is regulatd by USF transcription factors and Twist1 PMID: 23181698
  6. ALX3 could be considered as a candidate gene for the etiopathogenesis of diabetes or its complications during embryonic or fetal development is discussed PMID: 21350340
  7. ALX3 participates in the regulation of the expression of essential genes for the function of pancreatic islets, and its deficiency alters the regulation of glucose homeostasis in vivo. PMID: 21104068
  8. Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects. PMID: 20534379

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Subcellular Location
Nucleus.
Protein Families
Paired homeobox family
Tissue Specificity
Predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Prominent expression in frontonasal head mesenchyme and in the first and second pharyngeal arches and some of their derivatives. High expression is also seen in the tail and i
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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