Recombinant Mouse Hyaluronan-binding protein 2 (Habp2)

Code CSB-YP814290MO
MSDS
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Source Yeast
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Code CSB-EP814290MO
MSDS
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Source E.coli
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Code CSB-EP814290MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP814290MO
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP814290MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Habp2
Uniprot No.
Alternative Names
Habp2; Phbp; Hyaluronan-binding protein 2; EC 3.4.21.-; Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
Species
Mus musculus (Mouse)
Expression Region
24-311
Target Protein Sequence
LSLMSFI APPDPDWTPD DYYYSYEQSS PDEDPSVTQT TPENPDWYYE DDDPCQSNPC EHGGDCIIRG DTFSCSCPAP FSGSRCQTAQ NKCKDNPCVH GDCLITQKHP YYRCACKYPY TGPDCSKVLP ACRPNPCQNG GVCSRHRRRS RFTCACPDQY KGKFCEIGPD DCYVGDGYSY RGKVSKTVNQ NPCLYWNSHL LLQETYNMFM EDAETHGIAE HNFCRNPDGD HKPWCFVKVN SEKVKWEYCD VTVCPVPDTP NPVESLLEPV MELPGFESCG KTEVAEHAVK R
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.
Gene References into Functions
  1. FSAP deficiency causes an increase in CCL2 expression and CCL2-mediated infiltration of leukocytes into the injured vessel PMID: 27431088
  2. the promoter activity, which could phenocopy changes in Habp2 mRNA in response to TGF-beta, was found to be located in the 177-bp region upstream of the transcription start site, and this region did not contain any SMAD binding sites. PMID: 27462075
  3. Lack of endogenous FSAP impaired the formation of stable, occlusive thrombi in mice. PMID: 25427855
  4. Results show that the lack of FSAP in mice worsens the outcome of stroke; in the absence of FSAP there was a stronger inflammatory response and lower cell survival due to insufficient activation of the PI3K/AKT pathway PMID: 25615590
  5. Lower FSAP expression is associated with enhanced liver fibrosis and inflammation in patients with chronic hepatic disorders and murine experimental liver injury. PMID: 22989567
  6. Data indicate that FSAP mediates proteolytic cleavage and activation of bone morphogenetic protein-2 (BMP-2). PMID: 23341458
  7. Hyaluronic acid binding protein 2 (HABP2) negatively regulates vascular integrity via activation of protease-activated receptor/RhoA/Rho kinase signaling. It represents a potential therapeutic target for syndromes of increased vascular permeability. PMID: 20042707

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Subcellular Location
Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
Protein Families
Peptidase S1 family
Tissue Specificity
Liver and kidney.
Database Links

KEGG: mmu:226243

UniGene: Mm.25791

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