Recombinant Mouse Integrin alpha-E (Itgae), partial

1. The adoptive transfer of CD103(+) cDC1s to Batf3 deficient animals reversed these observed changes and more importantly could attenuate cellular damage and inflammation in established steatohepatitis. PMID: 28108233
2. Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta activation. PMID: 28423181
3. NR4A3 plays an important role in the regulation of CD103+ mDCs by regulating CCR7-dependent cell migration. PMID: 27820700
4. Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4) on a proportion of CD103+ CD11b+ dendritic cell (DC) in the intestinal lamina propria (LP). PMID: 27379516
5. while alphaE (CD103) expression is indeed associated with hTGFbeta1 in vivo, it has little, if any, influence on the course of the psoriasis-like phenotype in K5.hTGFbeta1 transgenic mice PMID: 26878989
6. Intestinal CD103(+)CD11b(-) dendritic cells restrain colitis via IFN-gamma-induced anti-inflammatory response in epithelial cells. PMID: 26174764
7. Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation. PMID: 26104914
8. CD103 on FoxP3+ Treg cells was involved in Treg retention to inflamed skin. PMID: 26203637
9. An important role for CD103 in the control of airway inflammation in asthma. PMID: 25681437
10. Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease. PMID: 26169940
11. CXCR3-dependent recruitment of cells to inflamed areas was critical for development of the CD8-positive, CD103-negative T lymphocyte population and pathogen clearance. PMID: 25706747
12. CD11c(+) CD103(+) cells of Mycobacterium tuberculosis-infected C57BL/6 but not of BALB/c mice induce a high frequency of interferon-gamma- or interleukin-17-producing CD4(+) cells. PMID: 25322675
13. ITGAE(+) cells play a key role in the development of autoimmune diabetes; this is consistent with the hypothesis that ITGAE(+)CD8(+)T effectors initiate the disease process. PMID: 25525188
14. CD103-CD11b+ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin. PMID: 23632327
15. Data indicate that CD103(+)CD8(+) T(RM) cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. PMID: 24162776
16. De novo Foxp3 expression in CD4+ T cells depends on CD103+ dendritic cell(DC)s and not plasmacytoid DCs to promote airway tolerance. PMID: 23733880
17. Data indicate that intestinal CD103+ dendritic cells are therefore equipped with unique mechanisms to independently complete the processes of uptake, transportation, and presentation of bacterial antigens. PMID: 23395676
18. Flt3-ligand administration resulted in a preferential expansion of CD103(+) DC that attenuated the severity of ileitis in 20-week-old TNFDeltaARE mice, mediated by increased CD4(+)/CD25(+)/FoxP3(+) regulatory T cells. PMID: 22068168
19. Unexpectedly, both CD103-positive and CD103-negative regulatory T cells (Tregs) have similar suppression capacity in vitro. PMID: 22664873
20. findings suggest that, of the two major LDCs, CD11b(high) LDCs more efficiently induce IgA than do CD103(+) LDCs, possibly through their potent capacity to produce IgA-inducing cytokines PMID: 22268142
21. knock-out mice display diminished Th2 priming to various inhaled allergens PMID: 22012243
22. small intestine goblet cells function as passages delivering low molecular weight soluble antigens from the intestinal lumen to underlying CD103(+) lamina propria-dendritic cells PMID: 22422267
23. E-cadherin and alpha(E)beta(7) integrin on dendritic epidermal T cells regulate their activation threshold through binding to E-cadherin on keratinocytes PMID: 21562159
24. CD103 is dispensable for intestinal immunity during helminth infection. PMID: 21573179
25. Data show a subset of CD103+CD8alpha+ LPDCs express TLR3, TLR7, and TLR9. PMID: 21525388
26. These data show that a lack of CD103 expression does not affect functional impairment of effector T-cell responses during chronic viral infection. PMID: 20565292
27. CD103 dendritic cells are an important subset in CD4(+) T cell-mediated autoimmune disease. PMID: 20421390
28. A significant population of dendritic cells within mesenteric lymph nodes and colonic lamina propria expressed the mucosal integrin CD103 which was lost during colitis. PMID: 20039445
29. results suggest the importance of alphaEbeta7 expression by TGF-beta in selective localization of intestinal intraepithelial T lymphocytes PMID: 11934870
30. report that CD4+ T cells expressing the integrin alpha(E)beta(7)represent previously uncharacterized subpopulations of regulatory T cells PMID: 12242333
31. expression is required for destruction of pancreatic islet allografts by CD8(+) T cells PMID: 12370250
32. AlphaEbeta7 integrin defines a unique population of peripheral lymph node-derived dendritic cells with altered functional properties and adhesive potential that localizes these cells to sites in lymph nodes where antigen presentation to T cells occurs. PMID: 14688336
33. Neonatal CD8+ splenocytes uniformly express alpha(E) integrin and exhibit a high responsiveness to CC chemokine ligand 25. With increasing age, the frequency of CD8+ alpha(E) integrin(+) splenocytes decreases, roughly correlating with thymic involution. PMID: 15187103
34. Chemokine CCL25 enhances CD103-mediated adhesion to E-cadherin. PMID: 15681774
35. Expression of CD103 is necessary for trafficking and retention of CD4+CD25+ regulatory T cells in the dermis and draining lymph nodes during chronic Leishmania major infection. PMID: 15845457
36. CD103-expressing dendritic cells residing in lung-draining bronchial lymph nodes are specialized in cross-presenting innocuous inhaled antigen (ovalbumin) in vivo. PMID: 17513734
37. mucosal CD103+ DCs induce Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism PMID: 17620361
38. Monocyte subsets that express both CD103 and CD11b(high) antigens give rise to two different types of dendritic cells (DCs) in the lung: CD103-positive or CD11b(high)-expressing DCs. PMID: 18292524
39. integrin alpha(E)(CD103)beta(7) is not only involved in epithelial retention, but also in shaping and proper intraepithelial morphogenesis of some leukocytes. PMID: 18492951
40. small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal inflammatory responses PMID: 18710932
41. CD103 had no significant impact on the development of primary and memory CD8(+) or CD4(+) responses after acute LCMV infection. CD103 was found to be dispensable for autoimmune diabetes progression in a CD8-mediated LCMV-induced autoimmune diabetes model. PMID: 19162441
42. M290-SAP dramatically reduces the frequency and absolute numbers of CD103-expressing leukocytes in the blood, spleen, mesenteric lymph nodes and intestinal epithelium of treated mice PMID: 19645708
43. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. PMID: 20008524

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KEGG: mmu:16407

STRING: 10090.ENSMUSP00000006101

UniGene: Mm.96