Recombinant Mouse Integrin alpha-E(Itgae) ,partial

Code CSB-YP730646MO
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Source Yeast
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Code CSB-EP730646MO
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Source E.coli
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Code CSB-EP730646MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP730646MO
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Source Baculovirus
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Code CSB-MP730646MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Itgae
Uniprot No. Q60677
Alternative Names Itgae; Integrin alpha-E; Integrin alpha M290; CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.
Gene References into Functions
  1. The adoptive transfer of CD103(+) cDC1s to Batf3 deficient animals reversed these observed changes and more importantly could attenuate cellular damage and inflammation in established steatohepatitis. PMID: 28108233
  2. Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta activation. PMID: 28423181
  3. NR4A3 plays an important role in the regulation of CD103+ mDCs by regulating CCR7-dependent cell migration. PMID: 27820700
  4. Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4) on a proportion of CD103+ CD11b+ dendritic cell (DC) in the intestinal lamina propria (LP). PMID: 27379516
  5. while alphaE (CD103) expression is indeed associated with hTGFbeta1 in vivo, it has little, if any, influence on the course of the psoriasis-like phenotype in K5.hTGFbeta1 transgenic mice PMID: 26878989
  6. Intestinal CD103(+)CD11b(-) dendritic cells restrain colitis via IFN-gamma-induced anti-inflammatory response in epithelial cells. PMID: 26174764
  7. Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation. PMID: 26104914
  8. CD103 on FoxP3+ Treg cells was involved in Treg retention to inflamed skin. PMID: 26203637
  9. An important role for CD103 in the control of airway inflammation in asthma. PMID: 25681437
  10. Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease. PMID: 26169940
  11. CXCR3-dependent recruitment of cells to inflamed areas was critical for development of the CD8-positive, CD103-negative T lymphocyte population and pathogen clearance. PMID: 25706747
  12. CD11c(+) CD103(+) cells of Mycobacterium tuberculosis-infected C57BL/6 but not of BALB/c mice induce a high frequency of interferon-gamma- or interleukin-17-producing CD4(+) cells. PMID: 25322675
  13. ITGAE(+) cells play a key role in the development of autoimmune diabetes; this is consistent with the hypothesis that ITGAE(+)CD8(+)T effectors initiate the disease process. PMID: 25525188
  14. CD103-CD11b+ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin. PMID: 23632327
  15. Data indicate that CD103(+)CD8(+) T(RM) cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. PMID: 24162776
  16. De novo Foxp3 expression in CD4+ T cells depends on CD103+ dendritic cell(DC)s and not plasmacytoid DCs to promote airway tolerance. PMID: 23733880
  17. Data indicate that intestinal CD103+ dendritic cells are therefore equipped with unique mechanisms to independently complete the processes of uptake, transportation, and presentation of bacterial antigens. PMID: 23395676
  18. Flt3-ligand administration resulted in a preferential expansion of CD103(+) DC that attenuated the severity of ileitis in 20-week-old TNFDeltaARE mice, mediated by increased CD4(+)/CD25(+)/FoxP3(+) regulatory T cells. PMID: 22068168
  19. Unexpectedly, both CD103-positive and CD103-negative regulatory T cells (Tregs) have similar suppression capacity in vitro. PMID: 22664873
  20. findings suggest that, of the two major LDCs, CD11b(high) LDCs more efficiently induce IgA than do CD103(+) LDCs, possibly through their potent capacity to produce IgA-inducing cytokines PMID: 22268142
  21. knock-out mice display diminished Th2 priming to various inhaled allergens PMID: 22012243
  22. small intestine goblet cells function as passages delivering low molecular weight soluble antigens from the intestinal lumen to underlying CD103(+) lamina propria-dendritic cells PMID: 22422267
  23. E-cadherin and alpha(E)beta(7) integrin on dendritic epidermal T cells regulate their activation threshold through binding to E-cadherin on keratinocytes PMID: 21562159
  24. CD103 is dispensable for intestinal immunity during helminth infection. PMID: 21573179
  25. Data show a subset of CD103+CD8alpha+ LPDCs express TLR3, TLR7, and TLR9. PMID: 21525388
  26. These data show that a lack of CD103 expression does not affect functional impairment of effector T-cell responses during chronic viral infection. PMID: 20565292
  27. CD103 dendritic cells are an important subset in CD4(+) T cell-mediated autoimmune disease. PMID: 20421390
  28. A significant population of dendritic cells within mesenteric lymph nodes and colonic lamina propria expressed the mucosal integrin CD103 which was lost during colitis. PMID: 20039445
  29. results suggest the importance of alphaEbeta7 expression by TGF-beta in selective localization of intestinal intraepithelial T lymphocytes PMID: 11934870
  30. report that CD4+ T cells expressing the integrin alpha(E)beta(7)represent previously uncharacterized subpopulations of regulatory T cells PMID: 12242333
  31. expression is required for destruction of pancreatic islet allografts by CD8(+) T cells PMID: 12370250
  32. AlphaEbeta7 integrin defines a unique population of peripheral lymph node-derived dendritic cells with altered functional properties and adhesive potential that localizes these cells to sites in lymph nodes where antigen presentation to T cells occurs. PMID: 14688336
  33. Neonatal CD8+ splenocytes uniformly express alpha(E) integrin and exhibit a high responsiveness to CC chemokine ligand 25. With increasing age, the frequency of CD8+ alpha(E) integrin(+) splenocytes decreases, roughly correlating with thymic involution. PMID: 15187103
  34. Chemokine CCL25 enhances CD103-mediated adhesion to E-cadherin. PMID: 15681774
  35. Expression of CD103 is necessary for trafficking and retention of CD4+CD25+ regulatory T cells in the dermis and draining lymph nodes during chronic Leishmania major infection. PMID: 15845457
  36. CD103-expressing dendritic cells residing in lung-draining bronchial lymph nodes are specialized in cross-presenting innocuous inhaled antigen (ovalbumin) in vivo. PMID: 17513734
  37. mucosal CD103+ DCs induce Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism PMID: 17620361
  38. Monocyte subsets that express both CD103 and CD11b(high) antigens give rise to two different types of dendritic cells (DCs) in the lung: CD103-positive or CD11b(high)-expressing DCs. PMID: 18292524
  39. integrin alpha(E)(CD103)beta(7) is not only involved in epithelial retention, but also in shaping and proper intraepithelial morphogenesis of some leukocytes. PMID: 18492951
  40. small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal inflammatory responses PMID: 18710932
  41. CD103 had no significant impact on the development of primary and memory CD8(+) or CD4(+) responses after acute LCMV infection. CD103 was found to be dispensable for autoimmune diabetes progression in a CD8-mediated LCMV-induced autoimmune diabetes model. PMID: 19162441
  42. M290-SAP dramatically reduces the frequency and absolute numbers of CD103-expressing leukocytes in the blood, spleen, mesenteric lymph nodes and intestinal epithelium of treated mice PMID: 19645708
  43. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. PMID: 20008524

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Integrin alpha chain family
Database Links

KEGG: mmu:16407

STRING: 10090.ENSMUSP00000006101

UniGene: Mm.96

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