Recombinant Mouse Integrin beta-4(Itgb4),partial

Code CSB-YP011887MO
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Source Yeast
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Code CSB-EP011887MO
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Source E.coli
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Code CSB-EP011887MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011887MO
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Source Baculovirus
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Code CSB-MP011887MO
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Itgb4Integrin beta-4; CD antigen CD104
Mus musculus (Mouse)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
Gene References into Functions
  1. Expression of the beta 4 subunit of the alpha 6 beta 4 integrin induces monocytic differentiation of 32D/v-Abl transformed cells. alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl kinases and p73 protein pathway(s). PMID: 12070014
  2. The results of this study suggested that ITGB4 knockout induced chronic inflammation mediated the comorbidity of asthma and bipolar disorder. PMID: 30170608
  3. he potential effect of Ntn-1 on angiogenesis is further verified by the mouse hindlimb ischemia model, where the pre-activation of hUCB-MSCs with Ntn-1 significantly improved vascular regeneration. These results demonstrate that Ntn-1 plays an important role in the tissue regeneration process of hUCB-MSC via the lipid raft-mediated Inalpha6beta4 signaling pathway. PMID: 27881869
  4. MARVELD1 mediated the invasion of trophoblast cells via regulation of the expression of integrin beta4 during placenta development. PMID: 28708243
  5. Integrin beta4 contributes to mammary gland development by sustaining PTHrP expression and enabling PTHrP signaling. PMID: 26432258
  6. keratins have a role in controlling beta4-integrin endocytosis involving a plectin-Erk1/2-dependent mechanism relevant for epidermal differentiation and pathogenesis PMID: 25668239
  7. Up-regulation of integrin beta4 and TRPV1 in migrating keratinocytes. PMID: 25637531
  8. Ectopic induction of Nur77 in endothelial cells is sufficient to improve skin wound healing. Furthermore, TR3/Nur77 regulates the expression of integrin beta4 by targeting its promoter activity. PMID: 25326539
  9. Col17a1/ keratinocytes exhibited increased spreading on laminin 332 and accelerated, but less directed cell motility. These effects were accompanied by increased expression of the integrin subunits beta4 and beta1. PMID: 24505282
  10. Both annexin A7 and integrin beta4 were essential for small molecule, 6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine-induced autophagy. PMID: 24007983
  11. Findings indicate a function for Id2 in regulating Snai1-mediated repression of integrin beta4. PMID: 23878399
  12. Lack of endothelial beta4 integrin had no effect on vascular development, integrity, or endothelial proliferation PMID: 23471230
  13. Targeted deletion of the signaling domain of beta4 inhibited prostate tumor growth and progression in response to loss of p53 and Rb function in a model of prostate cancer (PB-TAg mice). PMID: 23348745
  14. Deficiency of integrin alpha(6)beta(4) is modestly but significantly suppressed reporter-gene transduction by papillomaviruses in conditional integrin beta(4) knockout mice. PMID: 22995187
  15. aberrant expression of alpha6beta4 integrin in post-mitotic epidermal keratinocytes stimulates a pro-tumorigenic skin microenvironment PMID: 22464766
  16. The expression of beta4 integrin in interstitial, vessel-associated cells with myogenic activity within adult skeletal muscle. PMID: 22205679
  17. Data show that beta4 integrin associates with MMP9 and that its ectodomain is a target for cleavage by MMP9 in vivo under pathological conditions. PMID: 21750188
  18. Integrin beta4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF PMID: 21556948
  19. Data show that a previously unrecognized subpopulation of mouse alveolar epithelial cells expressing the laminin receptor alpha6beta4, but little or no pro-surfactant C, is endowed with regenerative potential. PMID: 21701069
  20. CD151 controls Met-dependent neoplastic growth by enhancing receptor signaling through beta4 integrin-mediated pathways, independent of cell-substrate adhesion PMID: 20937830
  21. EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin beta 4. PMID: 20870721
  22. Show increased integrin b4 in the endothelium of mouse thoracic aortas during natural aging and atherosclerosis. These data suggest that integrin b4 might be a potential target for therapy of cardiovascular diseases. PMID: 20509141
  23. cerebral hypoxia promotes first an endothelial response followed by astrocyte activation, proliferation, and reorganization of astrocyte end-feet, which correlates with increased expression of adhesion molecules alpha 6 beta 4 integrin and dystroglycan PMID: 20544851
  24. alpha(6)beta(4) has a generic influence on the invasion of carcinoma cells that is not specific to Met PMID: 15161909
  25. integrin alpha6beta4 is not required for postnatal epidermal differentiation, proliferation and survival, provided that cell adhesion is not compromised PMID: 15731010
  26. Integrin beta4 signaling promotes epidermal growth and wound healing through an effect on nuclear translocation of NF-kappaB and mitogen-activated protein kinases. PMID: 15988021
  27. both beta1 & beta4 integrins may have a role in implantation since immunoreactivity was seen on apical membrane of surface epithelium on day 4 when implantation occurred PMID: 16268053
  28. alpha5 is required for proliferation and polarity of basal epithelial cells; the interaction between laminin-10/11-integrin alpha6beta4 and the PI3-kinase-Cdc42/Rac pathways may play a role in determining the size and shape of tooth germ PMID: 16365040
  29. PMP22 is a binding partner in the integrin alpha6beta4/laminin complex. The levels of beta4 integrin are severely reduced in nerves of PMP22-deficient mice. PMID: 16436605
  30. These results indicate that beta 4 integrin promotes tumor progression by amplifying ErbB2 signaling and identify beta 4 as a potential target for molecular therapy of breast cancer. PMID: 16901783
  31. alpha6beta4 can either mediate an adhesion-independent tumor-suppressive effect or act as a tumor promotor PMID: 17699601
  32. Data suggest that integrin beta4 is a key factor in neuron survival and apoptosis and that this integrin subunit might perform its action through regulating NADPH oxidase and the level of reactive oxygen species in neuronal survival and apoptosis. PMID: 18006359
  33. Integrin beta-4 signaling plays a key role in mouse embryogenesis. PMID: 19087978
  34. Combinatorial selection based on phage display technology revealed a previously unrecognized complex between the soluble protein netrin-4 and laminin gamma1 subunit that activates an alpha6beta1 integrin-mediated signaling pathway in neural stem cells PMID: 19193855
  35. novel model for the disassembly of hemidesmosomes where both binding of calmodulin to plectin 1a and phosphorylation of integrin beta4 by protein kinases, are required for disruption of the integrin alpha6beta4-plectin complex PMID: 19419971
  36. report regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition. PMID: 19549682

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome.
Protein Families
Integrin beta chain family
Database Links

UniGene: Mm.213873

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