Recombinant Mouse Integrin beta-4 (Itgb4), partial

1. Expression of the beta 4 subunit of the alpha 6 beta 4 integrin induces monocytic differentiation of 32D/v-Abl transformed cells. alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl kinases and p73 protein pathway(s). PMID: 12070014
2. The results of this study suggested that ITGB4 knockout induced chronic inflammation mediated the comorbidity of asthma and bipolar disorder. PMID: 30170608
3. he potential effect of Ntn-1 on angiogenesis is further verified by the mouse hindlimb ischemia model, where the pre-activation of hUCB-MSCs with Ntn-1 significantly improved vascular regeneration. These results demonstrate that Ntn-1 plays an important role in the tissue regeneration process of hUCB-MSC via the lipid raft-mediated Inalpha6beta4 signaling pathway. PMID: 27881869
4. MARVELD1 mediated the invasion of trophoblast cells via regulation of the expression of integrin beta4 during placenta development. PMID: 28708243
5. Integrin beta4 contributes to mammary gland development by sustaining PTHrP expression and enabling PTHrP signaling. PMID: 26432258
6. keratins have a role in controlling beta4-integrin endocytosis involving a plectin-Erk1/2-dependent mechanism relevant for epidermal differentiation and pathogenesis PMID: 25668239
7. Up-regulation of integrin beta4 and TRPV1 in migrating keratinocytes. PMID: 25637531
8. Ectopic induction of Nur77 in endothelial cells is sufficient to improve skin wound healing. Furthermore, TR3/Nur77 regulates the expression of integrin beta4 by targeting its promoter activity. PMID: 25326539
9. Col17a1/ keratinocytes exhibited increased spreading on laminin 332 and accelerated, but less directed cell motility. These effects were accompanied by increased expression of the integrin subunits beta4 and beta1. PMID: 24505282
10. Both annexin A7 and integrin beta4 were essential for small molecule, 6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine-induced autophagy. PMID: 24007983
11. Findings indicate a function for Id2 in regulating Snai1-mediated repression of integrin beta4. PMID: 23878399
12. Lack of endothelial beta4 integrin had no effect on vascular development, integrity, or endothelial proliferation PMID: 23471230
13. Targeted deletion of the signaling domain of beta4 inhibited prostate tumor growth and progression in response to loss of p53 and Rb function in a model of prostate cancer (PB-TAg mice). PMID: 23348745
14. Deficiency of integrin alpha(6)beta(4) is modestly but significantly suppressed reporter-gene transduction by papillomaviruses in conditional integrin beta(4) knockout mice. PMID: 22995187
15. aberrant expression of alpha6beta4 integrin in post-mitotic epidermal keratinocytes stimulates a pro-tumorigenic skin microenvironment PMID: 22464766
16. The expression of beta4 integrin in interstitial, vessel-associated cells with myogenic activity within adult skeletal muscle. PMID: 22205679
17. Data show that beta4 integrin associates with MMP9 and that its ectodomain is a target for cleavage by MMP9 in vivo under pathological conditions. PMID: 21750188
18. Integrin beta4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF PMID: 21556948
19. Data show that a previously unrecognized subpopulation of mouse alveolar epithelial cells expressing the laminin receptor alpha6beta4, but little or no pro-surfactant C, is endowed with regenerative potential. PMID: 21701069
20. CD151 controls Met-dependent neoplastic growth by enhancing receptor signaling through beta4 integrin-mediated pathways, independent of cell-substrate adhesion PMID: 20937830
21. EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin beta 4. PMID: 20870721
22. Show increased integrin b4 in the endothelium of mouse thoracic aortas during natural aging and atherosclerosis. These data suggest that integrin b4 might be a potential target for therapy of cardiovascular diseases. PMID: 20509141
23. cerebral hypoxia promotes first an endothelial response followed by astrocyte activation, proliferation, and reorganization of astrocyte end-feet, which correlates with increased expression of adhesion molecules alpha 6 beta 4 integrin and dystroglycan PMID: 20544851
24. alpha(6)beta(4) has a generic influence on the invasion of carcinoma cells that is not specific to Met PMID: 15161909
25. integrin alpha6beta4 is not required for postnatal epidermal differentiation, proliferation and survival, provided that cell adhesion is not compromised PMID: 15731010
26. Integrin beta4 signaling promotes epidermal growth and wound healing through an effect on nuclear translocation of NF-kappaB and mitogen-activated protein kinases. PMID: 15988021
27. both beta1 & beta4 integrins may have a role in implantation since immunoreactivity was seen on apical membrane of surface epithelium on day 4 when implantation occurred PMID: 16268053
28. alpha5 is required for proliferation and polarity of basal epithelial cells; the interaction between laminin-10/11-integrin alpha6beta4 and the PI3-kinase-Cdc42/Rac pathways may play a role in determining the size and shape of tooth germ PMID: 16365040
29. PMP22 is a binding partner in the integrin alpha6beta4/laminin complex. The levels of beta4 integrin are severely reduced in nerves of PMP22-deficient mice. PMID: 16436605
30. These results indicate that beta 4 integrin promotes tumor progression by amplifying ErbB2 signaling and identify beta 4 as a potential target for molecular therapy of breast cancer. PMID: 16901783
31. alpha6beta4 can either mediate an adhesion-independent tumor-suppressive effect or act as a tumor promotor PMID: 17699601
32. Data suggest that integrin beta4 is a key factor in neuron survival and apoptosis and that this integrin subunit might perform its action through regulating NADPH oxidase and the level of reactive oxygen species in neuronal survival and apoptosis. PMID: 18006359
33. Integrin beta-4 signaling plays a key role in mouse embryogenesis. PMID: 19087978
34. Combinatorial selection based on phage display technology revealed a previously unrecognized complex between the soluble protein netrin-4 and laminin gamma1 subunit that activates an alpha6beta1 integrin-mediated signaling pathway in neural stem cells PMID: 19193855
35. novel model for the disassembly of hemidesmosomes where both binding of calmodulin to plectin 1a and phosphorylation of integrin beta4 by protein kinases, are required for disruption of the integrin alpha6beta4-plectin complex PMID: 19419971
36. report regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition. PMID: 19549682

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UniGene: Mm.213873