||IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV) and human immunodeficiency virus type 1 (HIV-1). Can inhibit
||Cell membrane, Single-pass type II membrane protein, Late endosome membrane, Single-pass type II membrane protein, Lysosome membrane, Single-pass type II membrane protein
||Expressed in acinar cell. Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells.