Recombinant Mouse Krueppel-like factor 10 (Klf10)

1. KLF10 and atrial natriuretic peptide/NPRA in exerting influences on chronic pulmonary disease pathogenesis PMID: 27592451
2. Authors demonstrate that targeting the SDF-1/CXCR4 pathway in the context of KLF10 deletion substantially suppresses PDAC progression. PMID: 28581520
3. In an animal endometriosis model, unlike wild-type controls, Klf10(-/-) animals developed cystic lesions with massive immune infiltrate and minimal peri-lesional fibrosis. The Klf10(-/-) disease progression phenotype also contrasted with prolific fibrosis and minimal immune cell infiltration seen in Klf11(-/-) animals. PMID: 27488034
4. TIEG1 is involved in regulating the canonical Wnt signaling pathway in bone through multiple mechanisms of action. PMID: 28201653
5. In clinical specimens of lung adenocarcinoma, low KLF10 expression associated with decreased patient survival, consistent with a pivotal role for KLF10 in distinguishing the antiproliferative versus prometastatic functions of TGFbeta. Our results establish that KLF10 functions to suppress TGFb-induced EMT, establishing a molecular basis for the dichotomy of TGFb function during tumor progression. PMID: 28249899
6. This study further implicates important roles for TIEG1 in the development of skeletal muscle and suggests that defects in TIEG1 expression and/or function may be associated with muscle disease. PMID: 27421714
7. Study has provided new insights into the role of TIEG1 in the functional and morphological properties of fast and slow twitch skeletal muscles. PMID: 27736981
8. our findings indicate that the absence of TIEG1 plays a cardioprotective role in ischaemic heart disease by promoting changes in Pten/Akt signalling. PMID: 28204828
9. Klf10 is involved in tooth development and promotes odontoblastic differentiation via the up-regulation of Dmp1 and Dspp transcription. PMID: 26310138
10. KLF10 deficiency predisposes to colitis through epigenetic regulation of TGFBRII expression and colonic macrophage dysregulation. PMID: 26472224
11. The KLF10 KO condition may reinforce the TGF-betaSmad signaling pathway. PMID: 25682863
12. these data implicate an important role for TIEG1 in mediating estrogen signaling throughout the mouse skeleton and suggest that defects in this pathway are likely to contribute to the sex-specific osteopenic phenotype PMID: 24190163
13. up-regulation of KLF10 was accompanied by increased TGFbeta signaling genes and suppressed ChREBP expression. These observations suggest possible association of KLF10 and NASH progression PMID: 24986741
14. To explore the role of KLF10 as an antiinflammatory factor in skin inflammation, we employed the phthalic anhydride-induced dermatitis model. These results support the role of KLF10 as an anti-inflammatory factor in chemical-induced skin inflammation. PMID: 23707674
15. RAF-1 phosphorylation and PIN1 isomerization together regulate KLF10 stability and further affect the role of KLF10 in tumor progression. PMID: 23994618
16. Demonstrate a protective role for bone marrow-derived KLF10 in paracrine and homing responses important for arterial endothelial injury. PMID: 23685559
17. KLF10 induces COX-1 protein expression and mRNA expression in endothelial cells. PMID: 23178857
18. Klf10 is a transcription factor that regulates the expression of IL-12p40 in bone marrow-derived macrophages. PMID: 23065757
19. TIEG1 knockout (TIEG1-/-) mice have a delay in wound closure related to an impairment in wound contraction, granulation tissue formation, collagen synthesis, and reepithelialization. PMID: 22380689
20. This study demonstrates that KLF10 is a tumor suppressor and that it targets p21(WAF1/CIP1) transcription. PMID: 22349513
21. Data from studies with knockout mice suggest that identify KLF10 and TGFbeta1 are key regulators of functional proangiogenic cells derived from bone marrow (i.e., myeloid progenitor cells and granulocyte-macrophage progenitor cells). PMID: 21828131
22. Tieg1 suppresses mammary tumorigenesis in xenografts in mice, and decreases lung metastasis by inhibition of Egfr gene transcription and the Egfr signaling pathway. PMID: 22025675
23. TIEG1 has a role in regulating the expression and activity of Runx2 in osteoblasts PMID: 21559363
24. Growth of TRAMP-C2 tumor was reduced in TIEG1 deficient mice and was accompanied by reduced Foxp3+ Tregs and an elevated Th17 response, suggesting that TIEG1 deficiency tilted the balance from suppressive toward effector immunity. PMID: 21471442
25. Increased AKT and MEK/ERK signaling pathway activation in TIEG1(-/-) osteoclasts was observed, consistent with the roles of these kinases in promoting osteoclast survival. PMID: 21423731
26. TIEG1 is a negative regulator of the myoblast pool that causes inhibition of myotube formation during myogenic differentiation. PMID: 20945337
27. These data further elucidate the role of TIEG1 on tendon structure and could explain the previous defects in the structure-function relationship found for TIEG1 KO tendon fibers. PMID: 20378701
28. Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork. PMID: 20070857
29. the expression of TIEG1 and TIEG2 was specific in different organs yet varied with different developmental time points. PMID: 20201061
30. These data establish KLF10 as a required circadian transcriptional regulator that links the molecular clock to energy metabolism in the liver. PMID: 20385766
31. these results confirm that TIEG directly binds to and inhibits OPG promoter activity in osteoblasts(OBs), partially explaining the inability of TIEG KO OBs to fully support osteoclast differentiation. PMID: 20059964
32. the bones of TIEG1 knockout mice display an osteopenic phenotype with significantly weaker bones and reduced amounts of cortical and trabecular bone PMID: 16876494
33. report a novel finding in the TGFbeta inducible early gene (TIEG) null mouse implicating TIEG1 in cardiac hypertrophy PMID: 16888812
34. Tieg1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade. PMID: 17659279
35. Results suggest that female TIEG(-/-) mice are osteopenic mainly due to a decrease in the total number of functional/mature osteoblasts. PMID: 18396127

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KEGG: mmu:21847

STRING: 10090.ENSMUSP00000073690

UniGene: Mm.4292