Recombinant Mouse LIM homeobox transcription factor 1-alpha (Lmx1a)

1. Data show that sustained expression of Lmx1a and Lmx1b is required for the survival of adult midbrain dopaminergic neurons. PMID: 27407143
2. Lmx1a and Lmx1b regulate Plxnc1 expression.Lmx1a is required for the topographical organization of dopaminergic innervation in the striatum. PMID: 29038581
3. Lmx1a is expressed in enterochromaffin cells and functions downstream of Nkx2.2. PMID: 27287799
4. This study showed that spontaneous Lmx1a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period. PMID: 25907855
5. The data of this study that Oc-1 interacts with Lmx1a to promote ventral midbrain neural stem cells differentiation into dopamine neuron through Wnt1-Lmx1a pathway. PMID: 25747864
6. Lmx1a signaling in mouse embryonic stem cells contributes to a molecular cascade establishing neuronal specification. PMID: 24194952
7. our data demonstrate that key midbrain dopamine regulators (Nurr1, Pitx3, and Lmx1a) play overlapping as well as distinct roles during neurogenesis and neurotransmitter phenotype determination of mDA neurons PMID: 24172139
8. The data of this study suggested that aberrant anlage patterning and granule cell development lead to Purkinje cell ectopia, which ultimately causes abnormal cerebellar architecture in dreher. PMID: 23160833
9. dopamine transporter is a direct target of Lmx1a and emphasizes a novel role of Lmx1a as one of regulators of mature midbrain dopaminergic neurotransmitter phenotypes PMID: 22564125
10. Lmx1a mutant (dr/dr) embryos demonstrate a clear decrease in expression of the genes Grb10 and Rgs4. PMID: 23106268
11. The characterization of two new Lmx1a alleles highlights the critical role of this gene in the development of the cochlea and vestibular system. PMID: 23226461
12. Data conclude that Lmx1a is a useful marker for the extraction of progenitors of GABAergic or dopaminergic neurons. PMID: 22495882
13. The Lmx1a can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching. PMID: 21624811
14. This study demonstrated that Lmx1a and Lmx1b function cooperatively to regulate proliferation, specification, and differentiation of mDA progenitors, including their floor plate-like properties. PMID: 21880902
15. data establish that Lmx1b influences the differentiation of multiple neuronal subtypes in the ventral midbrain, whereas Lmx1a appears to be exclusively devoted to the differentiation of the dopamine neuron lineage PMID: 21752929
16. Generation of knockout mice expressing a GFP-reporter under the control of the Lmx1a locus. PMID: 21440093
17. In the developing cerebellum, Lmx1a is expressed in the roof plate, where it is required to segregate the roof plate lineage from neuronal rhombic lip derivatives. PMID: 20498066
18. obtained evidence that Lmx1a and Lmx1b cooperate with Foxa2 to specify mesDA neuron identity by gain-of-function approaches using transgenic mice PMID: 20035737
19. Lmx1a/Lmx1b null mutant mice fail to generate a hindbrain roof plate. Both genes act in concert to direct normal hindbrain formation. PMID: 19741143
20. Lmx1a is expressed in the dorsal midline (roof plate) of the neural tube, the cortical hem, the otic vesicles, the developing cerebellum and the notochord of developing mice PMID: 12351192
21. New spontaneous Lmx1a mutations and analysis of six additional suggest that all reported alleles mutations are null mutations. PMID: 17019651
22. Otx2 determines anterior identity that confers neurogenic activity to floor plate cells and specifies a mesencephalon-dopaminergic fate, at least in part through the induction of Lmx1a. PMID: 17670789
23. Expression of Lmx1a and Isl1 begins in the otocyst stage, with Lmx1a exclusively in the non-sensory and Isl1 in the prosensory epithelia. PMID: 18942141
24. Lmx1a expression restricts and sharpens Sox2 expression, thereby defining non-sensory and sensory epithelium. PMID: 18985389
25. results suggest that Lmx1a may be involved in postnatal development as well as in maintenance of some aspects of normal brain function PMID: 19111912
26. forced expression of Lmx1a, a transcription factor functioning as a determinant of mesDA neurons during embryogenesis, effectively can promote the generation of mesDA neurons from mouse and human embryonic stem cells. PMID: 19383789
27. In an Lmx1a functional null mutant, dreher, the inner ears lack a non-sensory structure, the endolymphatic duct, and the membranous labyrinth is poorly developed. These phenotypes are consistent with Lmx1a's role as a selector gene. PMID: 19540218
28. Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development PMID: 19607821

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KEGG: mmu:110648

STRING: 10090.ENSMUSP00000028003

UniGene: Mm.330081