Recombinant Mouse Low-density lipoprotein receptor-related protein 2 (Lrp2), partial

1. megalin is critical for mitochondrial biology; mitochondrial intracrine signaling is a continuum of the retrograde early endosome-to-Golgi-Rab32 pathway and defects in this pathway may underlie disease processes in many systems. PMID: 29916093
2. TTR neuritogenic activity is mediated by the megalin receptor and is lost in megalin-deficient neurons. PMID: 27518433
3. in a bleomycin-based model of acute lung injury, megalin(+/-) animals (the megalin(-/-) variant is lethal due to postnatal respiratory failure) showed a marked increase in intra-alveolar protein and more severe lung injury compared with wild-type littermates PMID: 28678521
4. Cell type-specific glycoforms of megalin exist in the proximal tubular cells and modulate ligand absorption capacity. PMID: 27773703
5. This study evaluated the role of transcobalamin (TC), the transcobalamin receptor (CD320) , and megalin in various tissues during pregnancy. PMID: 28351841
6. miR-148b negatively regulates megalin expression in unilateral ureteral obstruction-induced kidney injury. PMID: 28331063
7. Exocytosis-mediated urinary C-megalin excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin-mediated lysosomal dysfunction in proximal tubules. PMID: 28289043
8. LRP2 plays a crucial role in cardiovascular development in mice. PMID: 26822476
9. Foxg1-Cre mediated Lrp2 inactivation in developing mouse neural retina, ciliary and retinal pigment epithelia is a model of congenital high myopia PMID: 26107939
10. megalin-deficient mice may provide a valuable model for future studies of megalin in ocular physiology and pathology. PMID: 24980834
11. LRP2 is essential for cellular folate uptake in the developing neural tube, a crucial step for proper neural tube closure. PMID: 24639464
12. Multiligand endocytic receptor megalin may be involved in AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells. PMID: 24740791
13. SNPs in the CYP24A1, CYP2R1, calcium sensing receptor (CASR), vitamin D binding protein (GC), retinoid X receptor-alpha (RXRA) and megalin (LRP2) genes were significantly associated with pancreas cancer risk. PMID: 23826131
14. Lrp2 is a novel target gene by progesterone and progesterone receptor. PMID: 24140060
15. Data indicate that uptake of Sepp1 and Gpx3 by d-13 visceral yolk sac was independent of apoER2 and megalin. PMID: 23651543
16. megalin mutation causes Donnai-Barrow/Facio-Oculo-Acustico-Renal syndrome. PMID: 23048173
17. In the olfactory epithelium, megalin was found to be specifically expressed in sustentacular cells and the Megalin protein was located in their microvilli PMID: 21818577
18. megalin might exhibit a proinflammatory effect by the uptake of retinoids in recruited monocytes, which thereby differentiate to liver macrophages and potentiate fibrogenesis by the release of proinflammatory mediators PMID: 21939757
19. PPARalpha/gamma and their agonists positively control megalin expression.This regulation could have an important impact on pathophysiologies such as chronic kidney disease associated with diabetes and hypertension, in which megalin expression is impaired. PMID: 21311715
20. Results provide evidence that MESD functions as a general LRP chaperone and suggest that the Mesd phenotype results from both signaling and endocytic defects resulting from misfolding of multiple LRP receptors. PMID: 21337463
21. Megalin is involved in the renal reabsorption of radiolabelled octreotide, octreotate, exendin, neurotensin and minigastrin. PMID: 21170526
22. megalin-dependent endocytosis has a role along the proximal nephron in the intrarenal renin angiotensin system PMID: 20966072
23. Results confirm that megalin interacts with APP and FE65, suggesting that these three proteins form a tripartite complex. PMID: 20637285
24. Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain PMID: 20653565
25. The progressive loss of megalin suggests that transport of metallothionein-I+II into the degenerating photoreceptors (from e.g., Muller cells), could be impaired in retinitis pigmentosa PMID: 20357188
26. in ependymal cells, regulates adult neurogenesis PMID: 20460439
27. is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12). PMID: 11832420
28. Expression profiling confirms a crucial role for megalin in renal vitamin D metabolism. PMID: 12371967
29. endocytic receptors megalin and cubilin are involved in renal reabsorption of myoglobin PMID: 12724130
30. In RAP-deficient mice megalin expression was strongly reduced and restricted to a subapical localization and NaP(i)-IIa protein distribution and abundance in the kidney was not altered. PMID: 12748857
31. megalin has a role in thyroid homeostasis with possible implications in thyroid diseases PMID: 14657389
32. Megalin expression in the visceral ectoderm increases as embronic development progresses; strong expression of megalin is also observed in the neural ectoderm, neural plate and neural tube. PMID: 14983511
33. results support a major role of megalin in thyroid hormone secretion PMID: 15878230
34. the His-sRAP-induced acceleration of megalin-mediated endocytosis causes phosphaturia via altered subcellular distribution of NaPi-II [39-kD receptor-associated protein (RAP)] PMID: 15976002
35. Megalin-mediated endocytosis in kidney proximal tubules prevents apoM excretion in the urine. PMID: 16099815
36. The megalin, an endocytic receptor in reproductive tissues, acts as a pathway for cellular uptake of biologically active androgens and estrogens bound to sex hormone binding globulin(SHBG). PMID: 16143106
37. These findings suggest that megalin has a crucial role in the development of astrocytes of the spinal cord. PMID: 16196028
38. Megalin mediates IGF-I-induced clearance of Abeta and is involved in IGF-I transport into brain. Attenuated IGF-I/megalin input may contribute to increased risk of neurodegeneration, including late-onset Alzheimer's disease. PMID: 16306401
39. Megalin in the ES lumen is a soluble component and may be endocytosed by the ES epithelial cells. Furthermore, we found that the tectorial membrane, an acellular structure in the cochlea, gave a strong megalin immunoreaction. PMID: 17063000
40. enhanced protein endocytosis led to upregulation of profibrotic mediators in a megalin-dependent way; however, no evidence that endocytosis played a pathogenetic role in the development of the tubulointerstitial disease in magalin deficiency PMID: 17460141
41. demonstrate that homozygous megalin mutant mice exhibit profound hearing loss at 3 months of age associated with features of presbycusis PMID: 17846082
42. Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst. PMID: 18083160
43. kidney selenium homeostasis is mediated by a megalin-dependent Sepp1 uptake pathway in the proximal tubule PMID: 18174160
44. Megalin is essential in astro-oligodendroglial interactions during development of the spinal cord. PMID: 18388738
45. Inactivation of RFC1 impacts the expression of several ligands and interacting proteins in the cubilin-amnionless-megalin complex that are involved in the maternal-fetal transport of folate and other nutrients. PMID: 18400109
46. megalin plays a pivotal role in the reabsorption of small to large molecular size proteins and provides direct in vivo evidence that reabsorption of filtered proteins triggers events leading to tubule injury. PMID: 18769366
47. The neuritogenic effect of transthyretin is dependent on megalin-mediated internalization during nerve regeneration. PMID: 19279259

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KEGG: mmu:14725

STRING: 10090.ENSMUSP00000079752

UniGene: Mm.23847