Recombinant Mouse Monocarboxylate transporter 1 (Slc16a1), partial

1. Silencing or genetic deletion of MCT1 in vivo inhibited migration, invasion, and spontaneous metastasis. PMID: 28827372
2. It was concluded that both MCT1 and CAII are involved in the homeostatic control of pH in skeletal muscle, both at rest and at the onset of exercise. The improved muscle function and resistance to fatigue in MCT1(+/-) mice remain unexplained. PMID: 28254758
3. Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice PMID: 25907793
4. Chronic lactate administration after exercise increases MCT1 protein expression, which can be involved in the regulation of the observed increase in muscle glycogen storage after exercise training. PMID: 25866305
5. This study showed that mouse MCT1, MCT2, and MCT4 are expressed in the PNS. While DRG neurons express MCT1, myelinating Schwann cells. PMID: 25762662
6. These data for the first time demonstrate that MCT1 is critical for regeneration of both sensory and motor axons in mice following sciatic nerve crush PMID: 25447940
7. in Parkinson's disease, the levels of MCT1, MCT2 and GLUT1 is not changed following dopaminergic neurodegeneration PMID: 23963315
8. results suggest that a reduction in mitochondria is a result, rather than the cause, of the metabolic deficiency observed in Basigin-null mice, and likely occurs because of reduced metabolic activity in the absence of MCT1 expression. PMID: 23906756
9. miR-29a, miR-29b selectively target MCT1 3'UTR ; the miR-29 isoforms are highly expressed in islets and contribute to silencing Mct1 in beta cells; miR-29 isoforms contribute to beta-cell-specific silencing of the MCT1 transporter and may affect insulin release PMID: 21646425
10. monocarboxylate transporter 1 (MCT1), is highly enriched within oligodendroglia and disruption of this transporter produces axon damage and neuron loss in animal and cell culture models; in addition, this same transporter is reduced in patients with, and in mouse models of, amyotrophic lateral sclerosis, suggesting a role for oligodendroglial MCT1 in pathogenesis PMID: 22801498
11. It was shown that forced overexpression of MSlc16a1 in beta-cells replicates the key features of exercise-induced hyperinsulinism and highlights the importance of this transporter's absence from these cells for the normal control of insulin secretion. PMID: 22522610
12. MCT1 and MCT4 protein expression increased by 92 and 61%, respectively, after 12 days of functional overload (p < 0.05). PMID: 21826525
13. Data suggest that basigin interacts with MCT1 and MCT2 to locate them properly in the membrane of spermatogenic cells and that this may enable sperm to utilize lactate as an energy substrate contributing to cell survival. PMID: 21792931
14. MCT-1 contributes to NOX-2 expression via late phase activation of NF-kappaB in a ROS-dependent manner in ATDC5 cells exposed to IL-1beta. PMID: 21372137
15. Basigin gene products bind MCT1 with moderate affinity, but L1cam does not bind MCT1. PMID: 20155396
16. In situ hybridization survey of MCT subtypes in placenta detected intense mRNA expression of MCT1, MCT4, & MCT9 (gestational day 11.5 through day 18.5); subcellular localization of MCT1 & MCT4 in cell membrane is opposite polarity found in human. PMID: 20022372
17. hydrophobic residues at the N- and C-termini of the putative transmembrane domain of Basigin interact with MCT1, but the glutamate plays no role PMID: 19760495
18. Results demonstrate beyond doubt that MCT1 is by far the predominant monocarboxylate transporter present in cultured cortical astrocytes from newborn mice. PMID: 12836157
19. changes in MCT1 are complex, depending not only the accumulated exercise but also on the stage of training. PMID: 15107415
20. These observations suggest that Bsg is required for the proper localization of MCT1 in a wide range of cells but not in every cell type. PMID: 16612830
21. Expression of cerebral MCT isoforms can be modulated by alterations of peripheral metabolism, suggesting that the adult brain is sensitive and adapts to new metabolic states. PMID: 17599960
22. Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. PMID: 18375207
23. Cellular expression of a sodium-dependent monocarboxylate transporter (Slc5a8) and the MCT1/2 in the mouse kidney. PMID: 18751721
24. MCT1 plays a pivotal role in the control of basal proton-driven lactate flux in astrocytes PMID: 18761711
25. expression of MCT1 mRNA in the mammary gland, Harderian gland, and sebaceous gland. MCT1 was found baso-laterally in acinar cells of the mammary and Harderian glands. Alveolar cells of sebaceous glands in the skin, eyelids, and penis contained MCT1 PMID: 19048272
26. Data describe the expression of monocarboxylate transporter (MCT)1 in peripheral nerves of mice, and show that MCT1 immunoreactivity is found in the perineurial sheath and colocalized with GLUT1, while the endoneurial blood vessels express GLUT1 only. PMID: 19129673
27. MCT1 was localized in mitochondria, plasma membrane, and intercalated disks PMID: 19604494

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KEGG: mmu:20501

STRING: 10090.ENSMUSP00000045216

UniGene: Mm.9086