Recombinant Mouse Neurogenin-3 (Neurog3)

1. Dorsal pancreas dysgenesis and ectopic pancreas is Neurog3 dependent PMID: 30093553
2. Our data show that chemical inhibition of the H3K27me3 demethylases Jmjd3/Utx blunts Neurogenin3-dependent gene activation in vitro. Conversely, inhibition of the H3K27me3 methyltransferase Ezh2 enhances both the transactivation ability of Neurogenin3 in cultured cells and the formation of insulin-producing cells during directed differentiation from pluripotent cells PMID: 29530603
3. This reviews the expression and function of NEUROG3 in both mouse and human pancreatic development. [Review Article] PMID: 27615127
4. Data suggest that hepatocytes can be reprogrammed into insulin-producing cells in vivo by transfection of neurogenin-3, Pdx1, and MafA genes using non-viral hydrodynamics injection; this procedure was used in treatment of streptozotocin diabetes; fasting blood glucose was reduced to normal. (Pdx1 = pancreatic and duodenal homeobox 1; MafA = v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A) PMID: 28100871
5. Neurogenin3 controls its ability to promote pancreatic endocrine differentiation and to maintain beta cell function in the presence of pro-proliferation cues PMID: 28457793
6. Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors PMID: 28441528
7. limiting Neurog3 expression dramatically increased the proportional representation of Sox9(+) Neurog3(TA.LO) progenitors, with a doubling of its mitotic index relative to normal Neurog3 expression, suggesting that low Neurog3 expression is a defining feature of this cycling endocrine-biased state PMID: 27585590
8. inflammatory cytokine insults stimulate epithelial-to-mesenchymal transition (EMT) as well as the endocrine program in human pancreatic ductal cells via STAT3-dependent NGN3 activation. PMID: 27068459
9. Duplication of pre-existing beta-cells is not the sole source of new beta-cells during pregnancy; Ngn3 may be involved in this process. PMID: 24940737
10. data demonstrate that HIF1-alpha negatively controls beta cell differentiation in vivo by regulating NGN3 expression, and that this effect is mediated by signals from blood vessels. PMID: 25186293
11. Data indicate that all neurogenin 3 (Neurog3)-tuberous sclerosis complex 1 (Tsc1)-/- mice developed notable adenocarcinoma-like lesions in pancreas starting from the age of 100 days old. PMID: 25425965
12. Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury. PMID: 24925797
13. Hnf1b plays a crucial role in the regulatory networks that control pancreatic MPC expansion, acinar cell identity, duct morphogenesis and generation of endocrine precursors. PMID: 25715395
14. The role of neurogenin 3 and PD-L1 in the genesis of neo-islets in NOD mice is reported. PMID: 25332429
15. the prophylactic administration of Ad-hNgn3 before diabetic induction protected mice from developing hyperglycemia PMID: 24635696
16. Neurog3 establishes the posterior boundary of the serotonergic system by actively suppressing serotonergic specification in the spinal cord. PMID: 25392491
17. Insm1 works to promote endocrine cell differentiation in a pathway that involves Neurog3 and Ripply3 PMID: 25053427
18. three transcription factors, PDX1, NGN3 and MAFA, are very important in pancreatic development. Overexpression of these three factors can reprogram both pancreatic exocrine and SOX9-positive cells of the liver into cells resembling pancreatic beta cells PMID: 24312421
19. The role of Ngn3 in the specification of hypothalamic neurons controlling energy balance, is reported. PMID: 23649822
20. K cells could be reprogrammed partially to beta-cells through the combined expression of Nkx6.1 and Neurogenin3, and reaggregation in suspension culture. PMID: 24365150
21. Ngn3 activation in duct cells is not a signature for adult beta cell neogenesis. PMID: 23867457
22. Cytoplasmic Ngn3 is associated with microtubules and important for neuronal development. PMID: 23383123
23. these data uncover the potential functional cooperation between the endocrine lineage-determining factor Neurogenin3 and the widespread endoderm progenitor factor Foxa2 in the implementation of the endocrine developmental program in the pancreas. PMID: 23471965
24. Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment. PMID: 23370147
25. The results established a mechanism by which activation of STAT3 regulates the expression of NEUROG3 to subsequently drive differentiation of spermatogonial stem cells and progenitor spermatogonia. PMID: 22378757
26. Although Sox9 is required for Ngn3 induction, endocrine differentiation necessitates subsequent Sox9 downregulation and evasion from Notch activity via cell-autonomous repression of Sox9 by Ngn3. PMID: 22675211
27. mechanism of transdifferentiation of pancreatic exocrine cells to beta (beta) cells in vivo by Ngn3 PMID: 22150363
28. The results indicate that GLIS3 controls fetal islet differentiation via direct transactivation of Neurog3, a perturbation that causes neonatal diabetes in mice. PMID: 21786021
29. Forced expression of PLAG1 under the control of the Pdx1 or Ngn3 promoter in murine pancreas induces different degrees of endocrine hormone imbalances. PMID: 21294959
30. Findings show that the utility of manipulating Pdx1 and Ngn3 expression in a stage-specific manner as an important new strategy for the efficient generation of functionally immature insulin-producing beta-islet cells from ES cells. PMID: 21931641
31. These results reveal a previously unknown involvement of Formin1 in dendritogenesis and synaptogenesis and indicate that this protein is a key component of the Ngn3 signaling pathway that controls neuronal differentiation. PMID: 21818269
32. Neurogenin3 can trigger the conversion of Math6 from a poorly transcribed bivalent to an active monovalent state in vitro, hence providing a mechanism whereby Neurogenin3 may activate Math6 in endocrine progenitors PMID: 21676531
33. Ngn3 deficiency results in reduced branching and enlarged pancreatic duct-like structures, concomitant with Ngn3 promoter activation throughout the ductal epithelium and reduced Notch signaling PMID: 21888903
34. Data demonstrate that Ngn3 indirectly controls Snail2 protein expression post-transcriptionally to repress E-cadherin. PMID: 21287656
35. These results suggest that oestradiol regulates neurogenin 3 in primary hippocampal neurones by a nonclassical steroid signalling mechanism, which involves the down-regulation of Notch activity. PMID: 21251092
36. Results suggest that Insm2 plays an important role in the differentiation cascade of Ngn3/NeuroD1 signaling in pancreatic islets. PMID: 21343251
37. Neurog3 is essential for tuft cell differentiation. PMID: 21383077
38. Cdk4 promotes pancreatic beta cell development by directing E2f1-mediated activation of Ngn3 and increasing the pool of endocrine precursors PMID: 21490060
39. Neurogenin3 inhibits proliferation in pancreatic endocrine progenitors by inducing Cdkn1a. PMID: 21173230
40. Ngn3+ progenitors contribute to subsets of POMC, NPY, TH and SF1 neurons and is required for the specification of these neuronal subtypes in the ventral hypothalamus. PMID: 21074524
41. GDNF stimulates increased expression of transcription factors including Ngn3 during the embryonic stages of pancreas development. PMID: 20448145
42. blocking ngn-3 expression in the E11.5 embryonic pancreas results in reduced endocrine differentiation. PMID: 20471370
43. study report localization & subcellular distribution of Ngn3 in the hippocampus in vivo & in neuronal cultures; results suggest that Ngn3 may play a role in neuronal development by actions in the cytoplasm PMID: 20235092
44. Thus, up-regulation of the hypothalamic NPY system is probably a feature characteristic of Ngn3 null mice. PMID: 20127365
45. OVOL1, a downstream target of NGN3, may play an important role in regulating the balance between proliferation and differentiation of pancreatic cells PMID: 19882138
46. control of Neurog3+ cell number and the Neurog3 threshold-dependent endocrine differentiation mechanism combine to select a specific proportion of pancreatic progenitor cells to adopt the islet cell fate PMID: 20025861
47. Rfx6 is dependent on Ngn3 and acts upstream of or in parallel with NeuroD, Pax4 and Arx transcription factors during islet cell differentiation. PMID: 20040487
48. NGN3+ cells are islet progenitors during embryogenesis and in adult mice. PMID: 11973276
49. Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity PMID: 12080087
50. Neurogenin3 and HNF1alpha activate the pax4 gene during the cascade of gene expression events that control pancreatic endocrine cell development PMID: 12837760

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KEGG: mmu:11925

STRING: 10090.ENSMUSP00000054054

UniGene: Mm.57236