Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-5 (Chrna5), partial

1. Data suggest that the Chrna5 D398N variant influences the effect of developmental nicotine exposure on nicotine intake of exposed offspring. This gene-environment interaction on striatal DA release may provide motivation for increased nicotine seeking in N Nic offspring and reduced consumption in D Nic offspring. PMID: 29573323
2. The findings reveal a proaddiction adaptive response to chronic nicotine in which nitric oxide and SST are released by a specific CHRNA5-expressing neuronal population to provide retrograde inhibition of the habenula- interpeduncular nucleus circuit and thereby enhance the motivational properties of nicotine. PMID: 29158387
3. Genetic deletion of alpha5 nAChR subunits leads to a behavioural phenotype that exactly matches that observed after antagonizing dopamine receptors. PMID: 28498560
4. Chrna5 KO mice did not exhibit high responses to novelty but showed decreased novelty-induced rearing behaviour together with high anxiety. Exposure to high doses of nicotine rescued these phenotypes. Results suggest that altered alpha5*-nAChR cholinergic signalling contributes to emotional/behavioural impairments that may be alleviated by nicotine consumption. PMID: 27385416
5. Results suggest that alpha5-containing nAChRs mediate analgesic tolerance to nicotine but do not play a major role in neuropathic pain PMID: 25725336
6. These results highlight the involvement of the alpha5 nAChR subunit in the development of hyperalgesia, allodynia and inflammation associated with chronic neuropathic and inflammatory pain models. PMID: 25931144
7. the alpha5 subunit of the nicotinic acetylcholine receptor has a critical role in defining the sensitivity of the Ventral Tegmental Area Dopamine system to nicotine. PMID: 24296975
8. Overexpression of the genomic cluster CHRNA5/A3/B4 in mice increases somatic signs associated with morphine withdrawal and Knockout of alpha5 gene reduced somatic signs in morphine-treated mice PMID: 24750073
9. The alpha5 subunit is critical for controlling the expression and functional role of a population of alpha4*-containing nAChRs in the ventral-tegmental area. PMID: 23869214
10. alpha5 in wild-type mice assembles into receptors that also contain the subunits alpha3, beta2, and beta4 PMID: 22380605
11. alpha5 nicotinic receptor subunits are critical to the regulation of dopamine transmission by alpha4beta2 receptors in regions of dorsal striatum associated with habitual and instrumental responses. PMID: 22396410
12. Normal developmental changes in nicotinic signaling and dendritic morphology in prefrontal cortex depend on alpha5-comprising nicotinic acetylcholine receptors. PMID: 22030359
13. These findings suggested that disrupting nicotinic receptors fundamentally alters the mechanisms and timing of excitation in prefrontal attentional circuitry. PMID: 22072695
14. Data reveal a highly regulated temporal-spatial pattern of alpha5 nAChR subunit expression during important periods of lung morphogenesis by FoxA2. PMID: 21682884
15. increased nicotine intake in mice with a null mutation in Chrna5 PMID: 21278726
16. This study demonstrated a novel and important role for the nicotinic receptor 5 subunit in adult brain circuitry required for attentional performance. PMID: 20610759
17. functional role and pharmacological properties PMID: 12122136
18. Alpha 5-containing nicotinic acetylcholine receptors participate in the modulation of colitis in mice PMID: 15973160
19. beta2-containing nAChRs are involved in the affective signs of nicotine withdrawal, whereas non-beta2-containing nAChRs are more closely associated with physical signs of nicotine withdrawal PMID: 18184829
20. Alpha5 nicotinic receptor gene deletion exerts a small but significant decrease in maximal acetylcholine-evoked [3H]gamma-aminobutyric acid release in hippocampus and striatum, with a more profound effect in cortex. PMID: 19139153

Show More

Hide All

KEGG: mmu:110835

STRING: 10090.ENSMUSP00000091365

UniGene: Mm.103778