Recombinant Mouse Nuclear receptor-interacting protein 1 (Nrip1), partial

1. Up-regulation of RIP140 promotes glucolipotoxicity-induced damage in pancreatic beta cells. PMID: 29631683
2. RIP140 is a co-repressor of HSF1, and it regulates neuronal stress response. PMID: 29233969
3. Data suggests that NRIP1 is overexpressed both in skin and PBMCs of psoriasis patients and may be involved in the abnormal proliferation and apoptosis of keratinocytes. PMID: 27708240
4. It is able to modulate the transcription of certain genes involved in AD pathology, such as b-APP cleaving enzyme (BACE1) and GSK3. Consequently, we found that RIP140 overexpression reduced the generation of Ab in a neuroblastoma cell line by decreasing the transcription of b-APP cleaving enzyme via a PPARge dependent mechanism. PMID: 27614112
5. These data indicate that dominant NRIP1 mutations can cause kidney and urinary tract by interference with retinoic acid transcriptional signaling, shedding light on the well documented association between abnormal vitamin A levels and renal malformations in humans, and suggest a possible gene-environment pathomechanism in this disease PMID: 28381549
6. RIP140 has a unique role in the acute effect of beta-3 adrenergic receptor activation. PMID: 28322782
7. depletion of receptor-interacting protein 140 could significantly alleviate the inhibitory effects of estrogen on osteoclasts formation and bone resorption activity. PMID: 27016936
8. Nuclear receptor interacting protein 140 (RIP140) is an identified nuclear receptor corepressor that has been shown to suppress mitochondrial biogenesis in skeletal muscle. PMID: 26360644
9. Data show that 7,12-dimethylbenzanthracene (DMBA)-induced carcinogenesis is suppressed in nuclear receptor interacting protein 1 (Nrip1) knockout mice. PMID: 26492163
10. RIP140 plays an important role in maintaining brain cholesterol homeostasis through, partially, regulating cholesterol metabolism in, and mobilization from, astrocyte. PMID: 25697398
11. RIP140 translocation to the cytoplasm is an early response to ER stress and provides protection against neuronal death. PMID: 25066731
12. Study revealed an emotional regulatory function of macrophage-derived RIP140 in the VMH, and secondary dysregulation of NPY within hypothalamic astrocyte population, which might be associated with the observed behavioral phenotype of MPhiRIPKD mice. PMID: 24726835
13. RIP140 knockdown in macrophages led to significant white adipose tissue browning, improved systemic insulin sensitivity, particularly under high fat diet feeding, and an altered adipose tissue macrophage profile. PMID: 24969109
14. RIP140 blocks the BRITE program in white adipose tissue. PMID: 24479876
15. RIP140 stimulated APC transcription and inhibited beta-catenin activation and target gene expression. PMID: 24667635
16. RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals. PMID: 23404106
17. RIP140 effectively inhibits the proliferation and facilitates the apoptosis of microglioma cells. PMID: 22321934
18. IGF1 may coregulate female sexual maturation and longevity; wild-derived strains carry specific alleles that delay sexual maturation; and Nrip1 is involved in regulating sexual maturation and may affect longevity by regulating IGF1 level. PMID: 22566614
19. Findings reinforce the participation of RIP140 in the maintenance of energy homeostasis by acting as an inhibitor of energy production. PMID: 22389706
20. The RIP140 gene depletion results in learning and memory deficits as well as stress response, bringing to light a major role for this transcriptional coregulator in the neurophysiological developmental mechanisms underlying cognitive functions. PMID: 21906262
21. Our results identify RelA as an adaptor with which the E3 ligase SCF fine tunes NF-kappaB target genes by targeting the coactivator RIP140 PMID: 22388040
22. this study reveals a new functional role for cytoplasmic RIP140 in modulating adiponectin vesicle secretion PMID: 21872658
23. Decreased RIP140 protein content not required for exercise and AMPK-dependent increases in skeletal muscle mitochondrial content. PMID: 21700896
24. not only involved in metabolic control but also acts as a coactivator for RORalpha, influencing clock gene expression PMID: 21628546
25. The blocking of cytoplasmic RIP140 accumulation reduces basal and isoproterenol-stimulated lipolysis and the pro-inflammatory potential of their conditioned media. PMID: 21504789
26. The study uncovers a cholesterol-miR-33-RIP140 regulatory pathway that modulates the proinflammatory potential in macrophages in response to an alteration in the intracellular cholesterol status. PMID: 21285396
27. a new, cytoplasmic function for RIP140 as a negative regulator of GLUT4 trafficking and glucose uptake PMID: 19945409
28. Data conclude that although the level of RIP140 expression in the ovary is a crucial for the transient expression of EGF-like factors necessary for cumulus expansion, it also plays a role in other signaling pathways that induce follicular rupture. PMID: 20308529
29. RIP140 may have a role in retinoic acid mediation of long-paced oscillations in retinoid receptor activity PMID: 19862326
30. Data demonstrate post-transcriptional regulation of RIP140 mRNA, involving the enhancing effect of a specific mir-346 that targets RIP140's 5'UTR. PMID: 19780716
31. Data show that a ligand-dependent transcriptional repressor for nuclear receptors, RIP140, plays a crucial role in regulating the balance between energy storage and energy expenditure. PMID: 15155905
32. important role for RIP140 in the regulation of multiple processes leading to ovulation PMID: 15919748
33. Reduction in the levels of RIP140 or prevention of its recruitment to nuclear receptors may provide novel mechanisms for the control of energy expenditure in adipose cells. PMID: 16227589
34. RIP140 is a major suppressor of adipocyte oxidative metabolism and mitochondrial biogenesis, as well as a negative regulator of whole-body glucose tolerance and energy expenditure in mice. PMID: 16374519
35. regulation of Ucp1 expression in the absence of RIP140 involves derepression of at least three different nuclear receptors PMID: 17456798
36. the function of RIP140 as a cofactor for LXR in liver varies according to the target genes and metabolic process, serving as a coactivator in lipogenesis but as a corepressor in gluconeogenesis PMID: 17684114
37. Results demonstrate that the nuclear receptor corepressor RIP140 is a key regulator of metabolism in skeletal muscle. PMID: 17767910
38. RIP140 serves as a scaffold for both DNA and HMT activities to inhibit gene transcription directing histone and DNA methylation to silence Ucp1 expression in white adipocytes two key epigenetic repression systems PMID: 17972916
39. Direct transcriptional inhibition of beta-adrenergic-receptor-mediated, cyclic AMP-dependent Ucp1 gene expression involves the differential recruitment of RIP140 to an LXRalpha binding site that overlapping the PPARgamma/PGC-1alpha response element. PMID: 18195045
40. ability of RIP140 to function as a coactivator for cytokine gene promoter activity relies on direct protein-protein interactions with the NFkappaB subunit RelA and histone acetylase cAMP-responsive element binding protein (CREB)-binding protein (CBP). PMID: 18469200
41. PKCepsilon stimulates arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation PMID: 18628823
42. These results demonstrate the signal transduction pathway, initiated from Erk2 activation for specific threonine phosphorylation, followed by p300 recruitment for lysine acetylation, which ultimately enhances the gene-repressive activity of RIP140. PMID: 18655826
43. Induction of RIP140 in liver provides a molecular rationale for hepatic steatosis in starvation, sepsis, or cancer cachexia. PMID: 18712775
44. Results describe the roles of RIP140 and PGC-1alpha in controlling the expression of CIDEA, an important regulatory factor in adipose cell function and obesity. PMID: 18794372
45. Kinetic analysis of PTMs of endogenous RIP140 in differentiated 3T3-L1 cells demonstrates sequential modifications on RIP140, initiated from constitutive lysine methylation, followed by increased arginine methylation later in differentiation. PMID: 19216533

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KEGG: mmu:268903

STRING: 10090.ENSMUSP00000051726

UniGene: Mm.447018