Recombinant Mouse Nuclear receptor subfamily 2 group C member 2 (Nr2c2)

1. TNFalpha-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating the decision between three distinct mechanisms of cell death: necroptosis, RIPK1-independent and dependent apoptosis. PMID: 28842570
2. The results suggest that an intron-free Renilla luciferase reporter may provide a satisfactory internal control for TR4 at certain dose range. Findings advocate caution on the use of Renilla luciferase as an internal control in TR4-directed studies to avoid misleading data interpretation. PMID: 28210900
3. We conclude that TR4 is required for the normal differentiation and proliferation of erythroid cells, in addition to its previously characterized roles in embryonic and fetal globin gene repression PMID: 29018082
4. CNS-specific Tak1 deletion prevented ER-stress-induced hypothalamic leptin resistance and hyperphagic obesity under a high-fat diet (HFD). Thus, TAK1 is a crucial regulator of ER stress in vivo, which could be a target for alleviation of ER stress and its associated disease conditions. PMID: 26985063
5. SIRT7 inhibits TR4 degradation by deacetylation of DDB1. PMID: 28623141
6. this study shows that TAK1 negatively regulates lipopolysaccharide-induced cytokine secretion in myeloid cells by inhibiting MEKK3 activities PMID: 27671672
7. TR4 binds GR to play an important role in glucocorticoid-directed corticotroph tumor POMC regulation in addition to modulating glucocorticoid actions on other GR targets. PMID: 27253665
8. The present study demonstrates that TIPE2 acts as a novel negative regulator of inflammatory and immune responses through TAK1 signaling. PMID: 27601471
9. this study shows that increased activity of TAK1 contributes to diabetic nephropathy PMID: 27268284
10. miR-133a regulates TR4 expression in ox-LDL-induced mouse RAW 264.7 macrophages PMID: 27109382
11. TAK1 participates in intestinal integrity through separately modulating bacteria-derived reactive oxygen species and receptor-interacting protein kinase 3-dependent Paneth cell loss. PMID: 27077812
12. We confirmed that PGC-1b inhibited downstream inflammatory signals via binding with TAB1 and thus preventing TAB1/TAK1 binding and TAK1 activation. PMID: 26748475
13. Hepatocyte TRAF3 promotes liver steatosis and insulin resistance through targeting TAK1-dependent signaling. PMID: 26882989
14. Bacterial polysaccharide-responsive miR-150 and miR-143 RIPK2 and TAK1 to suppress NOD2-induced immunomodulators. PMID: 26391398
15. TR4-mediated enhancement of fatty acid synthesis in adipocytes requires increased expression of PC gene PMID: 25240193
16. TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system. PMID: 24583925
17. These data provide new insights into our understanding of globin gene regulation and raise the interesting possibility that the PGC-1 coactivators can interact with TR4 to elicit differential stage-specific effects on globin gene transcription. PMID: 24662048
18. TR4 transcriptionally activates proopiomelanocortin through binding of a direct repeat 1 response element in the promoter, and that this is enhanced by MAPK-mediated TR4 phosphorylation. PMID: 23653479
19. The very profound pain and itch processing defects after TR4 deletion reflects loss of functionally distinct, and possibly independent, excitatory interneuronal circuits in the dorsal horn. PMID: 23622066
20. Data from TR4 knockout mice suggest that TR4 has function in maintaining normal osteoblast activity during bone development and remodeling; TR4 may bind directly to promoter region of osteocalcin gene and induce osteocalcin expression. PMID: 22676849
21. TR4 regulated the GADD45A expression through TR4 response elements located in intron 3 of the GADD45A gene. PMID: 22396141
22. investigation of role of TR4 in penile physiology/sexual behavior using knockout mice: TR4-/- males exhibit severe reproductive malfunctions, abnormal sexual behavior, and loss of erectile function. TR4 binds/activates nNOS promoter/response element. PMID: 21995792
23. Testicular nuclear receptor 4 (TR4) regulates UV light-induced responses via Cockayne syndrome B protein-mediated transcription-coupled DNA repair PMID: 21918225
24. TR4 plays vital roles in mitochondrial function. PMID: 21622535
25. microRNA-mediated silencing of TR4 in 3T3-L1 adipocytes drastically reduced basal FATP1 5' promoter activity and FATP1 expression with reduced lipid accumulation. PMID: 21843524
26. A novel role of TR4 in mediating the interplay between oxidative stress defense and aging. PMID: 21521714
27. TR4 transactivation is inhibited via phosphorylation by metformin-induced AMP-activated protein kinase (AMPK) at the amino acid serine 351, which results in the suppression of SCD1 gene expression. PMID: 21478464
28. TAK1 plays a critical role in the regulation of energy and lipid homeostasis and may provide a new therapeutic target in the management of obesity, diabetes, and liver steatosis. PMID: 20864514
29. Data show that gamma-linoleic acid positively modulates TR4 activity to promote the expression of downstream genes apolipoprotein E (ApoE) and phosphoenolpyruvate carboxykinase. PMID: 19800043
30. TR4 can also regulate apolipoprotein E, C-I, and C-II gene expression via the TR4 response element within the hepatic control region PMID: 12954636
31. TR4 plays a critical role in the late meiotic prophase and subsequent division in spermatogenesis PMID: 15199144
32. plays important roles in growth, embryonic and early postnatal pup survival, female reproductive function, and maternal behavior PMID: 15477591
33. TR4 is required for normal cerebellar development PMID: 15767677
34. TR4 is required for proper myelination in the CNS and is particularly important for oligodendrocyte differentiation and maturation in the forebrain regions. PMID: 17227886
35. These results demonstrate that TR4 might function as an apoptosis modulator through induction of Bcl-2 gene expression. PMID: 17655826
36. Results showed TR4 might play essential roles in normal folliculogenesis by influencing LHR signals. PMID: 18174360
37. Various TR4 knockout mouse models suggest that TR4 is required for normal cerebellar development and failure to establish proper cytoarchitecture results in dysfunction of the cerebellum and leads to abnormal behavior. PMID: 18418664
38. Reduced cluster of differentiation (CD)36 expression was found with reduced foam cell formation in TR4(-/-) mice. PMID: 19666541

Show More

Hide All

KEGG: mmu:22026

STRING: 10090.ENSMUSP00000109087

UniGene: Mm.442385