Recombinant Mouse Pituitary adenylate cyclase-activating polypeptide (Adcyap1)

1. Results show that lack of pituitary adenylate cyclase-activating polypeptide (PACAP) influences molecular and biomechanical properties of bone matrix, activating various signalling cascade changes in a compensatory fashion. PMID: 30150589
2. Low PACAP expression is associated with increased number of severely damaged sperms. PMID: 29101268
3. results suggest that IL-6 gene requires up-regulation of phospho-JAK2/STAT3, PACAP, and PAC1R and down-regulation of the TNF-alpha gene to modulate its anticonvulsive/neuroprotective potential PMID: 29673861
4. The data presented here shows PACAP38 transport is temporally altered following controlled cortical impact -treatment and PACAP38 uptake is greater in the cerebellum compared to the cortices PMID: 29107653
5. In conclusion, Pituitary adenylate cyclase activating polypeptidecan attenuate Mitoxantrone -mediated left ventricular dilation and dysfunction in mice. PMID: 28720396
6. This study shown the model of depression in PACAP mutation mice. PMID: 28450265
7. PACAP/PAC1 signaling is important for light regulated behavior, VIP/VPAC2 signaling for stable clock function and both signaling pathways may play a role in shaping diurnality versus nocturnality. PMID: 29155851
8. Results suggests that PACAP regulates a bidirectional interaction between the adult neural progenitor cells and their niche: PACAP modifies extracellular matrix production and remodeling, in turn the extracellular matrix regulates progenitor cell adherence. PACAP may in this manner help restrict adult neural progenitors to the stem cell niche in vivo. PMID: 28523979
9. age-related changes were observed in the PACAP KO mice only. These alterations included horizontal and rod bipolar cell dendritic sprouting into the photoreceptor layer and decreased ganglion cell number. Also, Muller glial cells showed elevated GFAP expression compared to the aging WT retinas. PMID: 28215987
10. Mice lacking endogenous PACAP have slower weight gain during the first weeks of development and slower neurobehavioral development. PMID: 28168413
11. Study investigated effects of chronic variable mild stress (CVMS) in non-injected, vehicle and imipramine-treated KO mice vs. wildtype (WT) counterparts and mapped the CVMS-related FosB response in 18 brain areas; found that PACAP deficiency affects neuronal reactivity in a brain area-specific manner in stress centers PMID: 27282087
12. Backup mechanisms maintain PACAP/VIP-induced arterial vasodilation in PACAP-deficient mice. PMID: 28490016
13. PACAP/PAC1 signaling has a role in light regulated food anticipatory activity PMID: 26757053
14. PACAP deficient mice exhibit attenuated acute restraint stress response and chronic restraint stress response. PMID: 25853791
15. not only homozygous but also heterozygous PACAP deficient mice are more vulnerable to kidney ischemia/reperfusion, further supporting the nephroprotective effects of the endogenous PACAP PMID: 26361682
16. PACAP expression in the dorsal root ganglion following spinal nerve injury is controlled through transcriptional repressor, REST. PMID: 26518165
17. This study demonstrated that Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide. PMID: 25889720
18. PACAP shows morphological actions via its cognate receptor PAC1. PMID: 25807538
19. This study suggests that PACAP(-/-) mice are an ideal rodent model with predictive validity for the study of ADHD etiology and drug development. PMID: 25841321
20. PACAP protects glomerular podocytes from inflammatory injuries PMID: 25821833
21. PACAP targets RCAN1 to control neuronal differentiation. PMID: 26157140
22. PACAP is up regulated in neurogenic inflammation in murine skin. PMID: 25905588
23. summarises the current understanding of the possible roles of PACAP and PAC1R in modulating hypothalamus and pituitary neuroendocrine cells in the mouse models PMID: 25303162
24. In PACAP-deficient mice with serum-transfer arthritis, joint swelling, vascular leakage, hyperalgesia, and early inflammatory cell accumulation are reduced; in the later phase of the disease, immune cell function and bone neoformation are increased. PMID: 25048575
25. the normal cold-induced increase in the basal metabolic rate and norepinephrine-induced increase in thermogenesis were severely blunted in cold-exposed Pacap(-/-) mice PMID: 25056115
26. PACAP is a crucial mediator of neuropathic mechanical hyperalgesia and neurogenic vasodilation. PMID: 23499760
27. PACAP activates ERK signaling during adipogenesis. PMID: 24039785
28. PACAP blocks canonical Shh signaling by a mechanism that involves activation of protein kinase A (PKA) and inhibition of the translocation of the Shh-dependent transcription factor Gli2 into the primary cilium. PMID: 23872071
29. PACAP may play a significant role in the complex interactions of gonadotropin and growth factors during ovulation and fertilisation. PMID: 23684890
30. Data suggest that PACAP regulates expression of SelT (selenoprotein T) in pancreatic beta- and delta-cells and is involved in control of insulin secretion and, thus, glucose homeostasis. PMID: 23913443
31. The results indicate that endogenous PACAP acts to maintain the integrity of DA neurons during exposure to PQ, an action that may be linked to its ability to regulate microglia and/or other immune cells. PMID: 23500093
32. Chronically elevated corticosterone is a key component of depressive effects of social defeat, and attenuation of the CORT response in PACAP-deficient mice protects from development of depressive behavior. PMID: 23062748
33. constitutive expression of PACAP may confer neuroprotection to central visceromotor neurons in a mouse model of amyotrophic lateral sclerosis PMID: 23466699
34. PACAP-/- mice at postnatal day 7 show respiratory arrest in response to hypoxia. PMID: 23136967
35. The results of this study suggested that PACAP elicits temporally specific effects on cortical proliferation via developmentally regulated expression of specific receptor isoforms. PMID: 23447598
36. Our novel findings document the importance of PACAP-mediated cAMP-PKA signaling in hepatic homeostasis and cytoprotection in vivo. PMID: 22532103
37. PACAP protects neurons and other tissues against ischemic, toxic, and traumatic lesions. Review. PMID: 22528455
38. With cyclophosphamide-induced cystitis, PACAP transcript expression significantly increased in the urothelium (48 h) and detrusor (4 h) of NGF-OE mice. PMID: 22700375
39. PACAP overexpression reduced the insulin levels required to compenstate for hyperglycemia. PACAP is involved in the regulation of hyperinsulinemia and islet hyperplasia in type 2 diabetes. PMID: 22477644
40. Both the longitudinal and transverse sperm head diameters were significantly lower in PACAP deficient mice, without marked difference in the shape. Lack of endogenous PACAP leads to abnormal sperm morphology. PMID: 22638857
41. PACAP mRNA increased gradually for 14 days after spinal cord injury and has a neuroprotective effect on the damaged spinal cord. PMID: 22674051
42. The increased immunoreactivity of Ca2 binding proteins in the absence of PACAP provide further evidence the important role of PACAP in the hearing processes. PMID: 22203609
43. PACAP and VIP are endogenous mediators that likely regulate immunity and immune-mediated diseases within the skin. PMID: 22531916
44. propose that PACAP exerts a brain area-specific effect on stress-induced neuronal activation and it might contribute to stress-related mood disorders PMID: 22178610
45. Data suggest that endogenous PACAP exerts an inhibitory role on myelination in vivo. PMID: 21726625
46. The esults clearly show that endogenous PACAP reacts as a stress-response peptide that is necessary for endogenous protection against different retinal insults. PMID: 21717232
47. PACAP affects gonadotropin expression and sexual maturation in vivo PMID: 22315445
48. Pituitary adenylate cyclase-activating polypeptide 38 ameliorated renal tubular injury, and reduced oxidative injury PMID: 21383633
49. stimulation with exogenous PACAP and native neuronal stress stimulation both lead to a PKC-mediated phosphodependent recruitment of a T-type Ca(v)3.2 Ca(2+) influx, which in turn evokes catecholamine release during the acute sympathetic stress response PMID: 22009744
50. Endogenous PACAP is partly involved in survival of the enriched environment-induced generation, but not in the basal rate, of newborn cells in the dentate gyrus of the adult hippocampus. PMID: 20974227

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KEGG: mmu:11516

STRING: 10090.ENSMUSP00000067057

UniGene: Mm.3407