Recombinant Mouse Pre-B-cell leukemia transcription factor 1 (Pbx1)

1. uc.40 may play an important role during the differentiation of P19 cells by regulation of PBX1 to promote proliferation and inhibit apoptosis. PMID: 30112697
2. Expression of PBX1 in leukemia cells enhances chemo-resistance and colony formation. PMID: 28034988
3. Pbx-dependent Epithelial-mesenchymal transition programs mediate murine upper lip/primary palate morphogenesis and fusion via regulation of Snail1. PMID: 29437830
4. results indicate Pbx genes act in parallel genetic pathways to orchestrate neuronal subtype differentiation, connectivity, and organization. I PMID: 27568519
5. PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2. PMID: 27226325
6. Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4(+) T cell effector function PMID: 27296664
7. FLT3-ITD is capable of inhibiting FLT3-ITD+ cell proliferation through the p21/Pbx1 axis PMID: 27387666
8. non-cell autonomous functions of Pbx factors within the splenic niche contribute to the regulation of hematopoiesis PMID: 27075259
9. Both histone H3 lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2. PMID: 26832413
10. Thus, PTBP1 controls the activity of Pbx1 to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development. PMID: 26705333
11. this study showed that the lupus susceptibility gene Pbx1 not only contributes to autoimmune pathology by impairing T cell tolerance, but also impairs the function of mesenchymal stem cells, which may also contribute to the disease directly or indirectly. PMID: 25416808
12. Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning. PMID: 26138478
13. Results thus show how Pbx1 controls Fgf10 in the developing lung. PMID: 24591256
14. These results demonstrate a role for Pbx1 in restraining myeloid maturation while maintaining lymphoid potential to appropriately regulate progenitor reservoirs. PMID: 23660001
15. The Systemic Lupus Erythematosus-associated Pbx1-d isoform acts as a dominant-negative transcriptional regulator. PMID: 22992721
16. In Pbx1-deficient dopaminergic neurons, the high affinity netrin-1 receptor, deleted in colon cancer, is down-regulated. PMID: 22748019
17. Data suggest that PBX1 regulates adipocyte development at multiple levels, promoting the generation of NC-derived APs during embryogenesis, while favoring APs proliferation and preventing their commitment to the adipocyte lineage in postnatal life. PMID: 21922607
18. Pbx1 is a novel lupus susceptibility gene that regulates T cell activation and tolerance. PMID: 22180614
19. PBX1 plays a central role in attenuating the activity of HOXA10 as an activator of osteoblast-related genes. PMID: 21597276
20. Pbx genes share overlapping functions and Pbx1 and Emx2 genetically interact in pelvic formation. PMID: 21455939
21. Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1 PMID: 20627960
22. Chromatin-associated Pbx1 and Hoxa10 were present at osteoblast-related gene promoters preceding gene expression, but only Hoxa10 was associated with these promoters during transcription. PMID: 20439491
23. Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus PMID: 11912494
24. This protein showed consistent elevation in its levels after retinoic acid treatment in both the forelimbs and hindlimbs. PMID: 12397630
25. homeodomain proteins PBX1 and PREP1 are cellular factors involved in Moloney MLV transcription regulation PMID: 12529389
26. Pbx1 is an essential regulator of mesenchymal function during renal morphogenesis. PMID: 12591246
27. PBX1 complexed with HOXA9 and DNA, so that the posterior Hox hexapeptide adopts an altered conformation. PMID: 12923056
28. Findings establish a Pbx1-dependent pathway that regulates the expansion of steroidogenic factor-1 positive cells essential for adrenal formation and gonadal differentiation and demonstrate an early requirement for Pbx1 in urogenital development PMID: 14595835
29. E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells PMID: 15507449
30. Data suggest that Pbx1 acts together with multiple Hox proteins in the development of the caudal pharyngeal region, but that some functions of Hox proteins in this region are Pbx1-independent. PMID: 15581866
31. These studies establish a Pbx1-Hox11-dependent genetic and transcriptional pathway in spleen ontogeny. PMID: 15944191
32. evidence for a control of PBX1 intracellular distribution which is independent of MEINOX proteins, but is cell cycle correlated PMID: 16172981
33. Vp16-mediated transformation required the Meis1 function of binding to Pbx and DNA but to its C-terminal domain. PMID: 16648484
34. Pbx1/Pbx2 exert a primary hierarchical function on Hox genes, rather than behaving merely as Hox ancillary factors PMID: 16672333
35. An investigation of the entire Ad4BP/SF-1 gene locus revealed a fetal adrenal enhancer (FAdE) in intron 4 containing highly conserved binding sites for Pbx-Prep, Pbx-Hox, and Ad4BP/SF-1. PMID: 16705164
36. Role of Pbx1 in the maintenance of a functional adrenal cortex mediated by synergistic actions of Pbx1 and Sf-1 in the transcriptional regulation of the critical effector of adrenocortical differentiation, the ACTH receptor. PMID: 17082260
37. Pbx1 critically functions at a stage between hematopoietic stem cell development and B-cell commitment and, therefore, is one of the earliest-acting transcription factors that regulate de novo B-lineage lymphopoiesis. PMID: 17244677
38. Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. PMID: 18691704
39. Reduction or absence of Pbx2 or Pbx3 leads to Pbx1 haploinsufficiency and specific malformations that resemble tetralogy of Fallot, overriding aorta with ventricular septal defect, and bicuspid aortic valves. PMID: 18723445
40. Pbx1 makes a crucial contribution to distinct regulatory pathways in cardiovascular development. PMID: 18849531
41. Hoxa1-399 reduces Hoxa1-993/Pbx1 binding to the Hoxb1 SOct-R3 region PMID: 19115252
42. PBX1 interactions with HOX proteins and DNA are dispensable for retinoic acid-induced ability of embryonic stem cells to express neural genes and point to a possible involvement of PBX1 in the regulation of imprinted genes. PMID: 19148706

Show More

Hide All

KEGG: mmu:18514

STRING: 10090.ENSMUSP00000135516

UniGene: Mm.43358