Recombinant Mouse Prostaglandin G/H synthase 1 (Ptgs1)

1. IFNgamma upregulated microsomal prostaglandin E synthase-1 (mPGES-1) alongside cyclo-oxygenase (COX-1) within macrophage populations, resulting in sustained prostaglandin (PG)E2 biosynthesis. PMID: 28954232
2. Data (including data from studies in knockout mice) suggest that delayed parturition in Cox-1 knockout mice is result of impaired luteolysis and cervical dilation, despite the presence of strong uterine contractions. PMID: 29029054
3. Specific inhibition of PGE2 synthesis by targeting mPGES-1 may weaken host defense against bacterial infections. PMID: 27059285
4. role of cyclooxygenase-1 and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas PMID: 26444418
5. Suggest the expression of COX-1 and COX-2 in the urothelium protects bladder damage from radiation. PMID: 27386631
6. COX-1 inhibitor SC-560 has a protective effect on the thromboxane A2-mediated decrease in renal function in response to endotoxin. PMID: 26017977
7. Expression of COX-1 is essential for the protection of liver against chemical-induced hepatotoxicity and required for hepatic homeostatic maintenance. PMID: 25432964
8. Data suggest that multitarget FAAH/Cox blockade may provide a transformative approach to inflammatory bowel disease (IBD) and other pathologies in which fatty acid amide hydrolase/cyclooxygenases (FAAH, Cox-1, and Cox-2) are overactive. PMID: 25757568
9. In arteries from non-insulin-dependent diabetic mice, COX-1 remains a major contributor to the endothelial PGI2 synthesis that evokes vasoconstrictor activity under the pathological condition. PMID: 24878773
10. COX1/2-derived prostanoids appear to play an important role in the TLR response, with elevated cytokine levels following COX1/2 inhibition or genetic deletion. PMID: 23742950
11. Data suggest deletion of Cox1 delays ovarian follicle development prior to reproductive maturation of mutant mouse strain (Wv); inhibition of Cox1 (but not Cox2) may prolong ovarian follicle lifespan and delay the onset of premature ovarian failure. PMID: 23966321
12. role of COX-1 during maturation of adipocyte PMID: 23817787
13. The production of prostanoids found in the systemic circulation is driven overwhelmingly by COX-1 and not COX-2. PMID: 23874970
14. Prostaglandin G/H synthase is a moonlighting protein that functions both as a peroxidase as well as a cyclooxygenase. PMID: 8121489
15. Hematopoietic COX-1 deletion results in impairments in metabolic homeostasis which may be partly due to increased adipose tissue inflammation and dysregulated adipokine profile. PMID: 23987235
16. These observations suggest that COX-enzymes, most likely COX-1, are involved in cancer-elicited anorexia and weight loss PMID: 23305935
17. KLF10 induces COX-1 protein expression and mRNA expression in endothelial cells. PMID: 23178857
18. In the abdominal aorta, ACh evoked endothelium-dependent production of 6-keto-PGF(1alpha), which was abolished by COX-1(-/-), but not by COX-2(-/-). PMID: 22080487
19. Niacin evoked platelet COX-1-derived PGD biosynthesis. PMID: 22406532
20. Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells. PMID: 22001217
21. Astrocytes respond to lipopolysaccharide by a COX-2-dependent production of prostanoids, mainly vasoactive PGE(2), and suggest that the coordinated down-regulation of COX-1 facilitates PGE(2) production after TLR-4 activation. PMID: 22219191
22. Data suggest that inhibition of COX-1, COX-2, or both enzymes alone seems inadequate to explain the gastric toxicity of piroxicam in mast cell-deficient mice. PMID: 21858200
23. Cyclooxygenase-1 gene deltion resulted in an incresed proliferation and differentiation of hippocampal progenitor cells in the adult mouse brain druing neuroinflammation. PMID: 21694498
24. COX-1 may play a crucial role in the pathology of neuroinflammation PMID: 21680698
25. Cox-1-expressing cellular lineage is necessary to promote synovitis in vivo; Cox-1 activity is attributable to a bone marrow-derived lineage (hematopoietic) and not to a radioresistant mesenchymal (tissue) lineage. PMID: 21357261
26. ErbB4-stimulated COX-2 induction is part of the molecular mechanisms responsible for ErbB4-induced cell survival PMID: 20585313
27. A unique role for COX-1 in mediating chronic neuroinflammatory effects through PGE(2) production is suggested. PMID: 20412387
28. These results indicate that inhibition of COX-1 activity may be valid therapeutic strategy to reduce brain inflammatory response and neurodegeneration. PMID: 20157512
29. expressed in peritoneal macrophages and mast cells during acute peritonitis PMID: 19885646
30. A novel mechanism was identified whereby chronic increases in oxidative stress, produced by mitochondrial superoxide dismutase deficiency, impair vascular function via a hydrogen peroxide-dependent, COX1-dependent, endothelium-derived contracting factor PMID: 20304815
31. COX-1 and COX-2 seem to play an important role in renal ischemia and reperfusion injury, involving the secretion of pro-inflammatory cytokines, activation of neutrophils, and ROS production. PMID: 19711010
32. our results demonstrate that endothelial cells control neuronal injury via mPGES-1-derived PGE2 PMID: 19658194
33. These findings clearly demonstrate that the immediate corticosterone release seen after immune challenge with lipopolysaccharide is dependent on Cox-1 derived prostanoids PMID: 20034541
34. The absence of COX-1 or COX-2 did not appear to effect ocular development in KO mice. PMID: 19767186
35. In the hippocampus and cortex of LPS-treated mice, matrix metalloproteinase (MMP)-3 activity was significantly decreased in COX-1(-/-) mice PMID: 19844242
36. These data indicate that genetic background significantly modifies the blood pressure response to mPGES1 deficiency. PMID: 20065147
37. The tissue-specific, compensatory expression of cyclooxygenase-1 and -2 in transgenic mice. PMID: 11936618
38. Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. PMID: 12093889
39. constitutive and inducible enzymes affect dermal wound healing PMID: 12118094
40. after IL-1beta administration, COX1 is the major enzyme involved in the hypophagia PMID: 12183660
41. Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1. PMID: 12184998
42. Results fail to confirm the harmful effect of losing COX-1 activity due to gene knockout in a permanent endovascular middle cerebral artery occlusion stroke model. PMID: 12213634
43. Pre-epithelial alkaline layer is regulated by endogenous COX activity. PMID: 12411530
44. Data show that both cyclooxygenase-1 and -2 isoforms are involved in the negative modulation of adipocyte differentiation. PMID: 12576525
45. Site-specific expression in mouse kidney and relationship to prostaglandin metabolism. PMID: 12657565
46. Knocking out this enzyme affects body temperature regulation. PMID: 12664644
47. cyclooxygenase-1-coupled prostaglandin E2/D2 biosynthesis has a central role in skin repair PMID: 12713596
48. mPGES-2 is a unique PGES that can be coupled with both COXs and may play a role in the production of the PGE2 involved in both tissue homeostasis and disease. PMID: 12835322
49. PGE2 derived from either COX-1 or -2 is involved in regulation of gastric mucosal inflammation and contributes to maintenance of mucosal integrity during H. pylori infection via inhibition of TNF-alpha expression PMID: 12958020
50. Like its counterpart COX-1, COX-3 does not generally appear to be induced by acute inflammatory stimulation of the CNS. PMID: 14625089

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KEGG: mmu:19224

STRING: 10090.ENSMUSP00000059977

UniGene: Mm.275434