Recombinant Mouse Proteasome subunit beta type-9 (Psmb9)

1. down-regulation of IL-33 protein levels by IFN-gamma in pulmonary fibroblasts and in the lungs in vivo occurs through STAT1 and non-canonical use of the LMP2 proteasome PMID: 24619410
2. Data show that knockdown of i-proteasome catalytic subunit PSMB9 by short hairpin RNA (shRNA) decreased the expression of both PSMB9 and PSMB8 without affecting other catalytic subunits of the proteasome. PMID: 24164898
3. LMP2 has a role as a tumor-suppressor and may have a role in uterine leiomyosarcoma therapy PMID: 22355695
4. In this study, we have identified how LMP2 can exert its function in Ag processing PMID: 22772448
5. Mixed proteasomes present in LMP2-deficient mice compromise virtually every parameter of the immune response against influenza A virus, potentially through dysregulation of signaling pathways, such as the nuclear factor (NF)-kappaB pathway. PMID: 20228196
6. Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice. PMID: 11782352
7. The presence of immuno subunits in nonimmune tissues such as lens suggests that the immunoproteasome may also have nonimmune functions, such as that in lens differentiation. PMID: 12220526
8. Comparison of LMP2 KO mice and non-transgenic mice of the same background show that LMP2 KO mice exhibit a higher degree of motor function, but possess a similar level of cognitive function and ambulation. PMID: 15036617
9. Immunoproteasome LMP2 can at least in part determine subdominance and shape the epitope hierarchy of cytotoxic T cell responses in vivo. PMID: 15356141
10. Immunoproteasome LMP2 may affect CD8+ T cell responses to only a limited number of viral epitopes; its main biological function may lie elsewhere. PMID: 16002717
11. These results demonstrate the ability of the IFN-induced proteasome catalytic subunits to shape the HBV-specific CD8 T-cell response and thus potentially influence the progression of infection to acute or chronic disease. PMID: 17079320
12. two inducible subunits of the proteasome, lmp2 and lmp7, are transcriptionally up-regulated by heat shock; heat-shocked cells show enhanced presentation of immunoproteasome-dependent MHC I antigenic epitopes, but not immunoproteasome-independent epitopes PMID: 17142736
13. SOD1/LMP2-/- mice show no change in motor function decline, or survival compared to G93A SOD1 mice, suggesting that the loss of immuno-proteasome function in vivo does not significantly alter mutant SOD1-induced disease. PMID: 17482163
14. LMP-2 is required for normal proteasomal function and ischemic preconditioning induction in the heart. Its action may be related to PTEN protein degradation. PMID: 18728217

Show More

Hide All

KEGG: mmu:16912

STRING: 10090.ENSMUSP00000133499

UniGene: Mm.390983