Product Details

Purity

>85% (SDS-PAGE)

Target Names

Hexim1

Uniprot No.

Q8R409

Alternative Names

Hexim1; Clp1; Protein HEXIM1; Cardiac lineage protein 1

Species

Mus musculus (Mouse)

Expression Region

1-356

Target Protein Sequence

MAEPLLTEHQ HQPQTSNCTG AAVVHEEHTS ERPPSAEERV PKEDSRWQSR ASLQSGSRPG QEGEGGLKHQ LPPLQTNACP ELSSLEKGEK GQNGEDLSTG GASPSAEGEP MSESLVQPGH DSEATKQEAP AAGGEEPWGQ QQRQLGKKKH RRRPSKKKRH WKPYYKLTWE EKKKFDEKQS LRASRVRAEM FAKGQPVAPY NTTQFLMDDH DQEEPDLKTG LYPKRAAAKS DDTSDEDFVE EAGEEDGGSD GMGGDGSEFL QRDFSETYER YHAESLQNMS KQELIKEYLE LEKCLSRKED ENNRLRLESK RLGGVDARVR ELELELDRLR AENLQLLTEN ELHRQQERAP LSKFGD

Protein Length

full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.

Gene References into Functions

Trypanosoma cruzi (T. cruzi) infected mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene have compromised cardiac function, altered expression of both pro- and anti-inflammatory cytokines, and increased inflammation and fibrosis. The profound exacerbation of pathologic findings in the tissues of heart, lung, spleen, and intestines suggests a protective role for Hexim1 in T. cruzi infection. PMID: 28951318
Decreased Hexim-1 expression does not alter cholesterol metabolism in ApoE null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 respectively. PMID: 28013147
Hexim1 selectively modulates leptin-mediated signal transduction pathways in the hypothalamus. PMID: 26859361
conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1alpha and VEGF in the myocardium under hypoxic condition PMID: 25301555
HEXIM1 re-expression results in the induction of angiogenesis that allows for the co-ordination of tissue growth and angiogenesis during physiological hypertrophy PMID: 23585471
re-expression of HEXIM1 in mammary epithelial cells resulted in inhibition of metastasis to the lung PMID: 22964639
a crucial role for the HEXIM1/P-TEFb pathway in the regulation of satellite cell-mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases. PMID: 23023707
Our findings underscore the critical role of CLP-1 in remodeling of the genetic response during hypertrophy and fibrosis. PMID: 22308025
these results show that the improvement in cardiac function in CLP-1(+/-) mice after ischemia-reperfusion injury is achieved through the potentiation of redox signaling. PMID: 19931534
CLP-1 and the HAND transcription factors may be part of a genetic program critical to proper heart development, and their perturbation can lead to cardiomyopathy PMID: 15172687
HEXIM1 plays critical roles in coronary vessel development and myocardial growth PMID: 18079413
the reduced level of CLP-1 introduced in the background of elevated levels of cyclin T1 elevates derepression of P-TEFb activity and emphasizes the importance of the role of CLP-1 in the mechanism governing compensatory hypertrophy in cardiomyocytes. PMID: 19443839

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

HEXIM family

Tissue Specificity

Widely expressed with higher expression in heart, skeletal muscle and brain (at protein level).

Database Links

KEGG: mmu:192231

STRING: 10090.ENSMUSP00000057339

UniGene: Mm.8763

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Recombinant Mouse Protein HEXIM1 (Hexim1)

Product Details

Customer Reviews and Q&A

Target Background

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