Recombinant Mouse Receptor-type tyrosine-protein phosphatase alpha (Ptpra), partial

1. PTPalpha coordinates oligodendroglial and neuronal development and myelination. PMID: 28647856
2. RPTPalpha mediates proinflammatory and proinvasive signaling in rheumatoid arthritis fibroblast-like synoviocytes (FLS), correlating with the promotion of disease in an FLS-dependent model of rheumatoid arthritis. PMID: 26414708
3. Ptpra coordinates the regulation of the Fyn signaling pathway in corpus striatum. PMID: 25951993
4. PTPs alpha and epsilon play distinct roles in osteoclasts. PMID: 24694598
5. PTP-alpha promotes profibrotic signaling pathways in fibroblasts through control of cellular responsiveness to TGF-beta. PMID: 24650563
6. The focal adhesion targeting domain of FAK interacts with protein-tyrosine phosphatase-alpha to restrict IL1-induced Ca2+ release, ERK activation, and MMP-9 expression. PMID: 24821720
7. PTPalpha may be involved in the formation of axoglial junctions and ensheathment in small axons during myelination of the spinal cord. PMID: 23934023
8. Findings indicate Grb2 as a new FAK activator and in coordinating PTPalpha tyrosine phosphorylation to enable downstream integrin signaling and migration. PMID: 24248601
9. Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis. PMID: 23318421
10. Inflammation-induced connective tissue degradation involving fibroblasts requires functionally active PTPalpha. PMID: 23940616
11. study described a molecular complex of PTPalpha-BCAR3-Cas-Src; this complex forms in response to PTPalpha Tyr789 phosphorylation and mediates Cas localization to focal adhesions and Cas downstream signaling to promote cell migration PMID: 22801373
12. Protein-tyrosine phosphatase alpha acts in oligodendrocyte progenitor cells to limit self-renewal and facilitate differentiation. PMID: 22354965
13. protein kinase C and protein tyrosine phosphatase alpha participate in Src activation by 1alpha,25OH2 vitamin D3 in C2C12 skeletal muscle cells PMID: 21459125
14. the PTPalpha-mediated increase of NB-3 level at the cell surface represents a novel function of PTPalpha in NB-3 signaling in neural development PMID: 21622556
15. these findings indicate that PTPalpha acts as an Ag-stimulated Lyn-Fyn phosphatase and a critical positive regulator of these Src family kinases in FcepsilonRI signaling PMID: 20944008
16. The results suggest that transformation by PTPalpha involves at least one function other than, or in addition to, its activation of Src and that this depends on PTPalpha's extracellular domain. PMID: 20545765
17. Expression of CD45RA and -RC isoforms is increased 20- to 200-fold on T cells from mice with a loss-of-function mutation in RNA-binding protein heterogeneous nuclear ribonucleoprotein L-like, although total CD45 expression is unaltered. PMID: 20505149
18. Results describe the role of nitric oxide in regulating the focal adhesion proteins, Src, FAK, p130 Cas, and PTP-alpha. PMID: 20055753
19. A new model for mitotic activation of Src in which PP2A-mediated dephosphorylation of RPTPalpha pSer204 facilitates Src binding, is proposed. PMID: 20385765
20. Findings demonstrate that PTPalpha is a critical regulator of Fyn activation and of specific Fyn signaling events during differentiation, and is essential for promoting OPC differentiation and central nervous system myelination. PMID: 19812040
21. Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation PMID: 11923305
22. RPTPs have the capacity for inside-out signaling PMID: 12582170
23. protein tyrosine phosphatase PTP alpha has a role in induction of src kinase via protein kinase C PMID: 12826681
24. RPTRalpha is essential for hippocampal neuronal migration and long-term potentiation. PMID: 12912911
25. PTPalpha knockout mice show decreased anxiety without an increase in head dips and stretch-attend movements; during Morris water maze learning, PTPalpha-/- mice have increased latencies to reach the goal, but no memory deficit on probe trials. PMID: 12932834
26. PTPalpha is not a negative regulator of insulin signaling and does not perform an essential role in mediating the physiological action of insulin PMID: 14733908
27. Data show that the NCAM140 isoform directly interacts with the intracellular domain of the receptor-like protein tyrosine phosphatase RPTPalpha, a known activator of p59fyn PMID: 15623578
28. PTPalpha is a component of the complex Src family tyrosine kinase regulatory network in thymocytes and is required to suppress Fyn activity in unstimulated cells in a manner that is not compensated for by the major T cell PTP and SFK regulator, CD45. PMID: 16339530
29. We conclude that PTPepsilon and PTPalpha differ significantly in their regulation of Kv channels and Src in the system examined and that similarity between PTPs does not necessarily result in full functional redundancy in vivo. PMID: 16870705
30. Defective NMDAR activity in protein tyrosine phosphatase alpha(PTPalpha) deficiency may be linked to loss of PTPalpha as upstream regulator of proline-rich tyrosine kinase 2. PMID: 16899073
31. Exposure of RPTPalpha D2 to oxidants promotes formation of a cyclic sulfenamide species, a reversibly oxidized state of Cys723, accompanied by conformational changes of the D2 catalytic site. PMID: 17223692
32. LAR regulates IGF-1R signaling in vascular smooth muscle cells PMID: 17500057
33. PTPalpha and PTPalpha-Y789F have distinct activities in T cells and CD45 is a regulator of PTPalpha phosphorylation at tyrosine 789 in T cells PMID: 17507376
34. Data show that RPTPalpha is required for rigidity-dependent reinforcement of fibronectin (FN)-cytoskeleton bonds and the rigidity response in hippocampal neuron growth cones. PMID: 17940065
35. Mediates close homolog of L1 (CHL1) and contactin-6 (NB-3)-regulated apical dendrite projection in the developing caudal cortex. PMID: 18046458
36. RPTPalpha plays a critical role in HCN channel function via tyrosine dephosphorylation PMID: 18768480
37. Activation of c-Src and Fyn kinases by protein-tyrosine phosphatase RPTPalpha is substrate-specific and compatible with lipid raft localization. PMID: 18948260
38. Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration. PMID: 19420001
39. PTPalpha acts as an adaptor to mediate functional links between focal adhesions and the endoplasmic reticulum that enable IL-1-induced Ca2+ signaling. PMID: 19497848

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KEGG: mmu:19262

STRING: 10090.ENSMUSP00000076533

UniGene: Mm.224246