Recombinant Mouse Secreted frizzled-related protein 2(Sfrp2)

Code CSB-YP021139MO
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Source Yeast
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Code CSB-EP021139MO
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Source E.coli
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Code CSB-EP021139MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP021139MO
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Source Baculovirus
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Code CSB-MP021139MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Sfrp2
Uniprot No. P97299
Alternative Names Sfrp2; Sarp1; Sdf5; Secreted frizzled-related protein 2; sFRP-2; Protein SDF5; Secreted apoptosis-related protein 1; SARP-1
Species Mus musculus (Mouse)
Expression Region 25-295
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

(From Uniprot)
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.
Gene References into Functions
  1. FZD5 is a receptor for SFRP2 and mediates SFRP2-induced angiogenesis via calcineurin/NFATc3 pathway in endothelial cells. PMID: 28840375
  2. Sfrp2 expression in the niche is required to maintain the hematopoietic stem cell pool. PMID: 27299503
  3. these data reveal a novel mechanism that the Bmp4-Msx1 pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt antagonists. PMID: 27713059
  4. The functional versatility and signaling complexity of sFRP2 in cardiac fibrosis may be better defined. PMID: 27605451
  5. A novel role of Sfrp2 and Wnt6 in regulating the dynamic process of CPC proliferation and differentiation. PMID: 26071893
  6. SREBP-1 acts as a positive regulator of Sfrp2 transcription in chondrogenic cells. PMID: 25971371
  7. In cardiac fibroblasts, sFRP2 promotes cardiac fibrocalcification through activation of TNAP. PMID: 25972450
  8. SFRP2 is suggested to modulate the influx from extracellular calcium in the B cell receptor signaling pathway. PMID: 25370898
  9. sFRP2 controls apoptosis, cell fate and the Wnt pathway in intestinal epithelium. PMID: 25447442
  10. Bone morphogenetic protein 2 (BMP2), BMP4, and secreted frizzled related protein 2 are principal effectors of quiescence of adult mammalian retinal stem cells. PMID: 23843349
  11. Sfrp1 and Sfrp2 appear to have a positive regulatory function because Wnt/beta-catenin signaling in lens epithelial cells was reduced in Sfrp1 and Sfrp2 DKO mice PMID: 24140542
  12. Data show that PPARgamma protects against vascular calcification by inducing the expression of secreted frizzled-related protein-2, which functions as a Wnt5a antagonist. PMID: 23011131
  13. SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. PMID: 22290867
  14. wnt spreading is impaired in the retina of Sfrp1(-/-);Sfrp2(-/-) mice, but forced expression of Sfrp1 in the wing imaginal disc of Drosophila suppresses some effects of Wg PMID: 21896628
  15. as a novel anti-apoptosis gene, SPRP2 was present in hypertrophic scars. Importantly, shRNA targeting SFRP2 may provide a new approach to preventing the formation of HS PMID: 21287236
  16. The data of this study indicated that Sfrps inhibit the ADAM10 metalloprotease, which might have important implications in pathological events, including cancer and Alzheimer's disease. PMID: 21478884
  17. Study provides important new insight into the mechanisms by which sFRP2 increases MSC self-renewal leading to superior tissue engraftment and enhanced wound healing. PMID: 20826809
  18. overexpressing Sfrp2 suppresses the Planar cell polarity pathway; whilst local groups of fibers are often similarly oriented, they lack global orientation PMID: 19968984
  19. SFRP2 is a target of the Pax2 transcription factor PMID: 14561758
  20. multiple myeloma cells also suppress bone formation at least in part through an inhibition of the canonical Wnt pathway by secreting sFRP-2 PMID: 16030194
  21. Wnt regulation by Sfrp1 and Sfrp2 is required for embryonic patterning PMID: 16467359
  22. Data show that expression of both Sfrp2 and Sfrp5 during development of the Mullerian duct in male (XY) and female (XX) mouse embryos is dynamic and sexually dimorphic. PMID: 16700072
  23. VDR-mediated inhibition of Sfrp2 suppresses adipogenic differentiation of bone marrow stromal cells. PMID: 17212358
  24. Sfrp2 has a role in mediating the paracrine effects of Akt-mesenchymal stem cells on tissue repair PMID: 17251350
  25. These results provide the first measurement of binding affinity of sFRPs for a Wnt, which together with the measurement of antagonistic activity of sFRPs could help understand how sFRPs regulate Wnt signaling. PMID: 17462603
  26. The inhibitory effects of Sfrp2 on Wnt3a expression identify Sfrp2 as a "checkpoint gene," which exerts its control on cardiomyogenesis through regulation of Wnt3a transcription. PMID: 17916803
  27. In conclusion, we found that different repertoires of sFRPs exert differential effects on osteoblastic differentiation of mouse mesenchymal cells and cellular apoptosis of mouse osteoblasts in vitro. PMID: 18166153
  28. Study shows that inactivation of Sfrp1, Sfrp2, and Sfrp5 leads to fused somites formation in early-somite mouse embryos, simultaneously resulting in defective convergent extension, which causes severe shortening of the anteroposterior axis. PMID: 18257070
  29. it is concluded that Sfrp1 and Sfrp2 act to prevent myoblasts from entering the terminal differentiation process PMID: 18322704
  30. our data establish a critical role for Sfrp2 in proper distal limb formation PMID: 18446812
  31. Data show that the single Sfrp2 inactivation in mice resulted in syndactyly and preaxial synpolydactyly, predominantly in the hindlimbs. PMID: 18729207
  32. study a novel mechanism of action of sFRP2, responsible for the activation of beta-catenin signaling PMID: 19001373
  33. Peri-infarct intramyocardial injection of sFRP2-MSCs resulted in enhanced engraftment, vascular density, reduced infarct size, and increased cardiac function after myocardial injury in mice PMID: 19017790
  34. This study thus uncovers a function for sFRP2 and a potential therapeutic application for sFRP2 antagonism in controlling fibrosis in the infarcted heart. PMID: 19079247
  35. Results report a redundant role for Sfrp1 and Sfrp2 in embryonic sexual development of the mouse. PMID: 19100252
  36. Sfrp regulation of Wnt5a signaling controls oriented cell division and apicobasal polarity in the epithelium of developing gut. PMID: 19300477
  37. These results indicate that although both SFRP-1 and SFRP-2 act as inhibitors for Wnt signaling in vitro, they differentially affect the homeostasis of hematopoietic stem cells. PMID: 19778523
  38. A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. PMID: 19850029

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Subcellular Location Secreted.
Protein Families Secreted frizzled-related protein (sFRP) family
Tissue Specificity Highly expressed in the eye. Weaker expression in heart and lung.
Database Links

KEGG: mmu:20319

STRING: 10090.ENSMUSP00000029625

UniGene: Mm.19155


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