Recombinant Mouse Short transient receptor potential channel 5 (Trpc5), partial

1. TRPC5 may not have a pivotal role in baroreflex regulation PMID: 29572499
2. Results suggest that activation of transient receptor potential channel 5 (TRPC5) contributes to the development of cholestasis and associated dyslipidemia. PMID: 28539583
3. TRPC5 channels represent a key pressure transducer in the baroreceptors and play an important role in maintaining blood pressure stability. PMID: 27411851
4. Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation. PMID: 27165180
5. that Arg-593, a residue located in the E4 loop near the TRPC5 extracellular Gd(3+) binding site, is critical for conferring the sensitivity to GPCR-Gq/11-PLC-dependent gating on TRPC5. PMID: 27920205
6. novel functions of TRPC5 in regulating vascular aging PMID: 28237267
7. TRPC5 contributes to depolarization of the plasma membrane in gonadotropes upon GnRH stimulation and increases the intracellular Ca2+ concentration via its own Ca2+ permeability and via the activation of voltage-gated Ca2+ channels. PMID: 28324107
8. Riluzole can activate TRPC5 heterologously expressed in HEK293 cells as well as those endogenously expressed in the U-87 glioblastoma cell line. PMID: 24117252
9. Loss or inhibition of TRPC5 abrogates podocyte cytoskeletal remodeling, prevents Rac1 activation, & stabilizes synaptopodin. Genetic deletion or pharmacologic inhibition of TRPC5 protected mice from albuminuria. PMID: 24231357
10. NEB cells selectively expressed the Ca(2+)-permeable osmo- and mechanosensitive TRPC5 in their apical membranes, whereas immunoreactivity for TRP vanilloid-4 and TRP melastatin-3 was abundant in virtually all other airway epithelial cells PMID: 22461428
11. TRPC5 acts downstream of semaphorin signaling to cause changes in neuronal growth cone morphology and nervous system development. PMID: 22547824
12. a novel function for TRPC5 that couples calcium signaling to a ubiquitin ligase pathway at the centrosome and thereby orchestrates dendrite patterning and connectivity in the brain PMID: 22135323
13. findings demonstrate that highly cold-sensitive TRPC5 channels are a molecular component for detection and regional adaptation to cold temperatures in the peripheral nervous system that is distinct from noxious cold sensing PMID: 22025699
14. The results of this study strongly suggested that the TRPC5 play a role in the CO(2) chemosensitivity of locus coeruleus. neurons. PMID: 21430274
15. Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. PMID: 20978238
16. Nitric oxide donors fail to modulate activity of mouse TRPC5 channels exogenously expressed in HEK293 cells. PMID: 20390293
17. mTRP5 might be a candidate for the nonselective cation channel activated by ACh or CCh in murine stomach. PMID: 12631560
18. Electrostatic attraction of cations by D633 may contribute to inward current amplitude in TRPC5. Cytosolic negatively charged residues can modulate the conductivity of TRP cation channels. PMID: 15689561
19. the desensitization of TRPC5 occurs via PKC phosphorylation and threonine at residue 972 of mouse TRPC5 might be required for its phosphorylation by PKC. PMID: 15843439
20. These results demonstrate that intracellular calcium has dual and opposite effects on the activation of TRPC5. PMID: 15987684
21. Results suggest that calmodulin and myosin light chain kinase modulate the activation process of transient receptor potential channel 5. PMID: 16306123
22. TRPC5 calcium channel has a lysophospholipid-sensing capability that confers the property of a lipid ionotropic receptor PMID: 16368680
23. New regulatory mechanism for TRPC5 channels. B subunit of cholera toxin-induced Ca2+ influx is mediated by TRPC5 channels. PMID: 17626205
24. analysis of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement PMID: 18495872
25. TRPC5 channels are activated by osmo-mechanical stimuli. TRPC5 channels are expressed in sensory neurones, which together with the osmo-mechanical characteristics of TRPC5 channels suggest its putative role in mechanosensory transduction events. PMID: 18832422
26. GM1 in T-effector cells to be the primary target of Gal-1 expressed by Treg cells, the resulting co-cross-linking and TRPC5 channel activation contributing importantly to the mechanism of autoimmune suppression PMID: 19299701
27. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. PMID: 19398778
28. These experiments provide genetic evidence that TRPC5, activated via G protein-coupled neuronal receptors, has an essential function in innate fear. PMID: 19450521
29. TRPC5 forms Ca(2+)-activated cation channels that are functionally coupled to Ca(2+)-selective ion channels through local Ca(2+) increases beneath the plasma membrane PMID: 19815560

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KEGG: mmu:22067

STRING: 10090.ENSMUSP00000049063

UniGene: Mm.328378