Recombinant Mouse Solute carrier family 12 member 1 (Slc12a1), partial

1. The differential regulation of ROMK, large-conductance Ca(2+)-activated K(+) (BK) channel, BK-alpha and NKCC2 between female and male mice, at least, were partly mediated via WNK1 pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control. PMID: 28237360
2. VAMP3 is required for normal NKCC2 expression, renal function, and blood pressure. PMID: 27551042
3. IL-1 receptor (IL-1R1) deficiency or blockade limits blood pressure elevation in this model by mitigating sodium reabsorption via the NKCC2 co-transporter in the nephron. PMID: 26712462
4. Data suggest renal cell lines exhibit an OS9- (osteosarcoma amplified 9 protein-)mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 prior to glycosylation/processing. PMID: 26721884
5. The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP. PMID: 26207612
6. our results suggest that NKCCs are involved in insulin secretion and that a single Slc12a2 allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1. PMID: 26400961
7. Vasopressin plays an important role in the colonic epithelia by stimulating NKCC2 trafficking to the apical membrane and inducing NKCC2-mediated ion transport. PMID: 24782621
8. In this systemic analysis no clear primary effects of the Slc12a1I299F mutation appeared for the organs other than the kidneys where Slc12a1 expression has been described. PMID: 25084970
9. increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase PMID: 24808538
10. Differential splicing of NKCC2 contributes to the adaptive capacity of the kidney to cope with changes in reabsorptive needs. PMID: 23946287
11. NKCC2A-dependent activation of NFAT5 is part of a pathway by which the medullary thick ascending limb produces TNF in response to hypertonic NaCl intake. PMID: 23269645
12. Abnormal anterograde trafficking as a common mechanism associated with mutations depriving NKCC2. PMID: 23105100
13. NKCC1 and NKCC2 were expressed in the gastric mucosa of rat, mouse and human. PMID: 22388656
14. In the kidneys, NKCC2 but not NCC is the main target of OSR1 and the reduced p-NKCC2 in KSP-OSR1(-/-) mice may lead to a Bartter-like syndrome. PMID: 21972418
15. a permissive role for THP in the modulation of NKCC2-dependent TAL salt reabsorptive function. PMID: 21737451
16. these findings suggest that TNF plays a role as an endogenous inhibitor of NKCC2 expression and function PMID: 21511694
17. These findings suggest that NKCC2A and NKCC2F exhibit differential effects on NFAT5 expression and transcriptional activity in response to hypertonicity produced by high NaCl concentration. PMID: 21228109
18. WNK1 is a negative regulator of NCC and NKCC2 in vivo and plays an important role in the control of Na(+) homeostasis and blood pressure. PMID: 21131289
19. SCAMP2 regulates NKCC2 transit through recycling endosomes and limits the cell surface targeting of the co-transporter by interfering with its exocytotic trafficking. PMID: 21205824
20. These data suggest a novel regulatory pathway whereby intracellular trafficking of SPAK by the sorting receptor SORLA is crucial for proper NKCC2 activation and for maintenance of renal ion balance. PMID: 20385770
21. A novel viable mouse line with a missense Slc12a1 mutation exhibits most of the features of type I Bartter syndrome and may represent a new model for the study of this human disease. PMID: 20219826
22. Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1) with the cotransporters KCC3, NKCC1, and NKCC2 but not KCC1 and KCC4 PMID: 12386165
23. examination of activation of NKCC2-mediated transport by WNK3 PMID: 16275913
24. Macula densa control of renin secretion and preglomerular resistance was studied with selective deletion of the B isoform of Nkcc2. PMID: 16807402
25. NKCC2 activates the tonicity-responsive enhancer binding protein (TonEBP) transcription factor by creating medullary hypertonicity PMID: 16926446
26. results identify the combination of amino acid variations responsible for differences among the three splice variants of NKCC2, and they support a model in which a reentrant loop following TM2 contributes to the chloride binding and translocation domains PMID: 17186942
27. Expression of both high- and low-affinity isoforms of NKCC2 permit transport and Cl-dependent tubuloglomerular feedback regulation to occur over a wider Chloride concentration range. PMID: 17215439
28. Results identify a novel phosphorylation site that maintains NKCC2-mediated transport under isotonic or basal conditions. PMID: 17341212
29. regulation of bumetanide-sensitive cotransporter type 1 by norepinephrine proceeds via the beta-adrenoceptor receptor-cAMP-protein kinase A pathway that involves in part mitogen-activated protein kinases. PMID: 17438304
30. NKCC2 surface expression in mammalian cells is shown to be downregulated by a novel interaction with aldolase B PMID: 17848580
31. a highly conserved motif at the COOH terminus dictates endoplasmic reticulum exit and cell surface expression of NKCC2 PMID: 19535327

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KEGG: mmu:20495

STRING: 10090.ENSMUSP00000028630

UniGene: Mm.3914