Recombinant Mouse Solute carrier family 12 member 3 (Slc12a3), partial

1. CD8+ T cells stimulate sodium/chloride co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension. PMID: 28067240
2. Urine output and water intake increased significantly only in pendrin KO mice in response to hydrochlorothiazide, but not in WT or NCC KO mice. PMID: 28750403
3. Calcineurin is activated by an acute potassium load, which rapidly dephosphorylates NCC, leading to increased urinary potassium excretion. PMID: 28341239
4. long-term aldosterone administration stimulates mouse NCC and pT58-NCC abundances in late distal convoluted kidney tubules. PMID: 27733368
5. Potassium depletion stimulates NCC via phosphorylation and inactivation of the KLHL3 and promoting increased blood pressure. PMID: 27942049
6. the increased NCC expression and activation is present in CMA which is highly associated with the enhanced WNK4-SPAK signal pathway using WNK4-/- and SPAK-/- mice. PMID: 26728390
7. The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation. PMID: 26963391
8. This study identifies NCC as an IL18-binding protein that collaborates with IL18r in cell signaling, inflammatory molecule expression, and experimental atherogenesis. PMID: 26099046
9. Slc12a3 mRNA and protein expression levels were upregulated in kidneys of db/db mice from 6, 12, and 26 weeks at the age. PMID: 25401745
10. SPAK-kinase-deficient mice, which are unable to activate NCC by phosphorylation, use multiple common compensatory mechanisms to blunt natriuresis and chloriuresis and to protect against a major drop in blood pressure. PMID: 25893600
11. NCC inhibition stimulates duodenal Ca(2+) absorption as well as osteoblast differentiation and bone Ca(2+) storage, possibly through a FAK/ERK dependent mechanism PMID: 24984877
12. P2Y2-mediated increase of cytoplasmic Ca(2+) concentration down-regulates the expression of NCC. PMID: 24463702
13. Estradiol, progesterone, and prolactin increase renal NaCl cotransporter phosphorylation and activity. PMID: 25587121
14. SPAK is an important mediator of the increased NCC activation by phosphorylation that occurs in the distal convoluted tubule in response to a low-K(+) diet, but other low-potassium-activated kinases are likely to be involved. PMID: 25651563
15. WNK4 is the major positive regulator of NCC in the kidneys. PMID: 24655003
16. Kcnj10 is a main contributor to the basolateral K conductance in the early distal convoluted tubule (DCT1) and determines the expression of the apical Na-Cl cotransporter (NCC) in the DCT. PMID: 25071208
17. The Na(+)-Cl(-) cotransporter NCC /Carbonic anhydrase II double Knockout mice displayed significant downregulation of pendrin, along with polyuria and salt wasting. PMID: 24429824
18. data demonstrate a role for Per1 in the transcriptional regulation of NCC, WNK1, and WNK4 PMID: 24610784
19. Reduction in phosphorylation in protein phosphatase 1 inhibitor-1 knockout mice PMID: 24231659
20. Ste20-related proline and alanine-rich kinase (SPAK)-mediated phosphorylation of NCC at tyrosine60 regulates NCC stability and function, and defective phosphorylation at this residue corrects the phenotype of pseudohypoaldosteronism type II. PMID: 23833262
21. Downregulation of NCC likely explains the natriuretic effect of an acute oral potassium load in mice. PMID: 23447069
22. Hsp70 and Hsp90 comprise two functionally distinct ER quality control checkpoints that sequentially monitor NCC biogenesis. PMID: 23482560
23. loss of NEDD4-2 in adult renal tubules causes a new form of mild, salt-sensitive hypertension without hyperkalemia that is characterized by upregulation of NCC, elevation of beta/gammaENaC, but not alphaENaC, and a normal Na+/K+ balance PMID: 23348737
24. Data indicate that SPAK and OSR1 function interdependently in the distal convoluted tubule (DCT) to positively regulate thiazide-sensitive sodium-chloride cotransporter, NCC. PMID: 22977235
25. NCC phosphorylation decreased NCC ubiquitination, which may contribute to the increase of NCC abundance mostly on plasma membranes. PMID: 22846565
26. The combined inhibition of pendrin and NCC can provide a strong diuretic regimen without causing hypokalemia. PMID: 22847418
27. NCC exhibits distinct ERAD requirements, which correlate with its transmembrane topology and distinguish it from other clients PMID: 22027832
28. The present results demonstrated that insulin is a potent regulator of NCC phosphorylation in the kidney. PMID: 21909387
29. Gene silencing of Ras-GRP1 prevented the PTH-mediated suppression of NCC activity, the activation of the H-Ras isoform of Ras, and the activation of ERK1/2 MAPK PMID: 22005268
30. upregulated by deficiency of Nedd4-2 in the renal tubules PMID: 21852580
31. Even though the increase in NCC activity in KS-WNK1(-/-) mice was less pronounced than in mice overexpressing a mutant form of WNK4, our study suggests that the activation of Na-Cl cotransporter is not sufficient to induce a hyperkalemic hypertension PMID: 20921400
32. Phorbol ester-mediated NCC endocytosis is dependent on ubiquitination via RasGRP1-mediated ERK1/2 activation. PMID: 20392800
33. Increased sensitivity to Angiotensin II in aging and male mice may involve overactivity of NCC PMID: 19844087
34. Mutations may impair insertion of functional protein into plasma membrane. Small increase in Cl(-) and thiazide affinity in G610S and G627V suggests that beginning of COOH-terminal domain could be implicated in defining kinetic properties. PMID: 15068971
35. examination of activation of NCC-mediated transport by WNK3 PMID: 16275913
36. important differences in the mechanism by which WNK kinases affect expression of NCCT PMID: 16788137
37. phosphorylation states of NCC and OSR1/SPAK were increased by low-salt diets and decreased by high-salt diets PMID: 18800028
38. review: NCC in the distal convoluted tubule plays a critical role in NaCl and, indirectly, in K+ homeostasis PMID: 19008908
39. AngII increases phosphorylation of specific sites on SPAK and NCC that are necessary for activation of each PMID: 19240212
40. WNK4 inhibits NCC activity by diverting the cotransporter to the lysosome for degradation by way of an AP-3 transport carrier PMID: 19401467
41. The C-terminal motifs contributed by exons 18 and 22 play an important role in the actions of WNK3 isoforms on NCCT. PMID: 19470686
42. Disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure in a mouse model. PMID: 19633012

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KEGG: mmu:20497

STRING: 10090.ENSMUSP00000034218

UniGene: Mm.25804