Product Details

Purity

>85% (SDS-PAGE)

Target Names

Slc22a2

Uniprot No.

O70577

Alternative Names

Slc22a2; Oct2; Solute carrier family 22 member 2; Organic cation transporter 2

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.

Gene References into Functions

Findings identify OCT2 as a genetic factor that directly impacts on the molecular and hormonal events taking place during acute stress, accentuating the noxious effects of repeated stress on the development of stress-related phenotypes PMID: 25092247
Molecular components of the circadian clock regulated the renal expression of Slc22a2, which resulted in rhythmic oscillations in OCT2 protein levels. PMID: 24567546
Cellular uptake of oxaliplatin increases by 16- to 35-fold in cells overexpressing Oct2, a process associated with increased DNA platination and oxaliplatin-induced cytotoxicity. PMID: 23776246
findings identify OCT2 as an important postsynaptic determinant of aminergic tonus and mood-related behaviors. PMID: 21769100
Slc22a2 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele. PMID: 11845212
OCT1 and OCT2 are important for N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) transfer across the blood-brain barrier and amantadine reduces the blood-brain barrier transfer of MPTP and MPTP-induced dopaminergic toxicity in rodents. PMID: 20477935
The carboxy-terminal activation domain of Oct-2 is required to mediate the unique and indispensable functions of the Oct-2 transcription factor in vivo. PMID: 14978099
adenovirus produced an increase in OCT-2 levels along with increased cellular OCT-2 steady-state mRNA in lung epithelial cells; results indicate that adenoviruses can disrupt choline trafficking in lung epithelia by upregulating expression of OCT-2 PMID: 15377492
demonstrate the membrane translocation of 3OH-GA mediated by NaDC3 and the cis-inhibitory effect on OCT2-mediated transport of cations PMID: 17356845
Deletion of Oct1 and Oct2 resulted in significantly impaired urinary excretion of cisplatin without an apparent influence on plasma levels. The Oct1/Oct2-deficient mice were protected from severe cisplatin-induced renal tubular damage. PMID: 19625999

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Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family

Tissue Specificity

Expressed in kidney and ureter. To a lower extent, also expressed in brain and embryo.

Database Links

KEGG: mmu:20518

STRING: 10090.ENSMUSP00000041186

UniGene: Mm.17322

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Recombinant Mouse Solute carrier family 22 member 2 (Slc22a2), partial

Product Details

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Target Background

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