Recombinant Mouse Steroid hormone receptor ERR1 (Esrra)

1. This work reveals a molecular mechanism by which ERRalpha-induced metabolic reprogramming promotes survival of lapatinib-resistant cancer cells. PMID: 27402251
2. the involvement of ERRalpha in the progression of cisplatin-induced AKI is probably through impaired mitochondrial dynamics PMID: 29545177
3. Localizing ESRRA binding sites in cortical chromatin, it has been shown that this nuclear receptor binds both differentially expressed energy-related and neurodevelopmental transcription factor genes during social challenge. PMID: 28356321
4. findings highlight a MYC/ERRalpha pathway that contributes to physiological and pathological bone loss by integrating the MYC/ERRalpha axis to drive metabolic reprogramming during osteoclast differentiation PMID: 28530645
5. Study performed a structural and functional assessment of glutamatergic synapses on medium spiny neurons in the nucleus accumbens of Esrra-null mice, and discovered sex-specific alterations in miniature excitatory postsynaptic currents frequency and amplitude, reduced paired-pulse ratio, and reduction in glutamatergic synaptic vesicles consistent with altered functional connectivity PMID: 27155145
6. The nuclear receptor, estrogen-related receptor alpha (ERRalpha), was shown to regulate the expression of genes required for lactate utilization. PMID: 27050525
7. In bone, the effects of cholesterol, statin, and bisphosphonate on osteoclastogenesis require ERRalpha; and consequently, cholesterol-induced bone loss or bisphosphonate osteoprotection is lost in ERRalpha knockout mice. PMID: 26777690
8. We conclude that E2-induced ERRalpha expression in endothelium plays an important role for the E2-induced vasculoprotective effect PMID: 26271712
9. These results indicate that Esrra deficiency in the mouse brain impairs behavioral responses in multiple functional domains. PMID: 25865889
10. Suppressed feeding behavior in novelty stress-exposed aged male mice may be mediated by 5-HT(2C)R hypersensitivity, leading to hypoghrelinemia. The hypersensitivity may partly be due to estrogen receptor activation in aged male mice. PMID: 25732068
11. study shows that ERRalpha plays a key role in directing transcriptional programs required for optimal mitochondrial oxidative potential and muscle fitness PMID: 25361393
12. Mice lacking both ERRalpha and cardiac Errg develop severe bradycardia, lethal cardiomyopathy, and heart failure featuring metabolic, contractile, and conduction dysfunctions. PMID: 25624346
13. This study shows that in C2C12 myotubes Ndrg2 is a novel PGC-1alpha/ERRalpha transcriptional target. PMID: 24008097
14. Loss of estrogen-related receptor alpha promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances. PMID: 24127579
15. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor alpha (ERRalpha). PMID: 23836899
16. ERRa-dependent control of metabolic gene programs is rapamycin sensitive, strategies aimed at enhancing rather than repressing ERRa activity appear to be a viable therapeutic avenue to relieve hepatic hyperlipidemia and steatosis. PMID: 23562079
17. conclude that the late (maturation), but not early (commitment), negative effects of ERRalpha on the osteoblast lineage contribute to the reduced bone mineral density observed upon estrogen deficiency PMID: 23359549
18. the repressive effect of NCoR1 on oxidative phosphorylation gene expression specifically antagonizes PGC-1alpha-mediated coactivation of ERRalpha PMID: 23028049
19. Suppression of ERalpha expression in the medial preoptic area almost completely abolished maternal care. PMID: 22988120
20. the 50-flanking region of the Cact gene contains a consensus sequence for ERRalpha. This sequence binds ERRa both in vivo and in vitro and is required for the activation of Cact expression by the PGC-1/ERR axis PMID: 22713466
21. Data identify ERRalpha as a new regulator of the Wnt-signaling pathway during osteoblast differentiation, through a cell-intrinsic mechanism not affecting beta-catenin nuclear translocation. PMID: 22333182
22. ERRalpha is a selective transcriptional regulator of Teff metabolism that may provide a metabolic means to modulate immunity PMID: 22042850
23. ERRalpha is required for normal skeletal myocyte differentiation via modulation of MAP kinase signaling. PMID: 21562305
24. ERRalpha in 3T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake PMID: 18544047
25. PGC-1alpha, ERRalpha, and mitofusin 2 may be important factors in the process of denervation-induced mitochondrial adaptation PMID: 21394548
26. ERRalpha regulates the diurnal expression of core clock and clock-controlled genes in the liver. PMID: 21731503
27. a novel function for ERK8 as a bona fide ERRalpha corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase in the regulation of the biological activities of this nuclear receptor. PMID: 21190936
28. Data show that the impairment of ERRalpha function does not alter osteoclasts precursor proliferation and differentiation but does alter the adhesion/spreading and migration capacities of mature OCs. PMID: 20841427
29. Results show that ERRalpha is an acetylated protein and imply the existence of a dynamic acetylation/deacetylation switch involved in the control of ERRalpha transcriptional activity. PMID: 20484414
30. these data propose a positive role for ERRalpha in osteoblastic and adipocytic differentiation. PMID: 20417614
31. ERRalpha has a role in bone loss induced by age or estrogen-deficiency PMID: 19936213
32. ERRaKO female mice are resistant to ovariectomy-induced bone loss PMID: 19936213
33. Prox1 interacts with ERRalpha and PGC-1alpha, occupies promoters of metabolic genes on a genome-wide scale, and inhibits the activity of the ERRalpha/PGC-1alpha complex PMID: 20194433
34. Data from genomic studies using male ERRalpha knockout mice suggest role of ERRalpha as pleiotropic regulator of renal control of blood pressure, renal Na+/K+ homeostasis, and renin-angiotensin pathway. PMID: 19901197
35. Differential ER effects on growth and development in various estrogen-responsive tissues. Findings suggest that nonclassical ER signaling pathways play an important physiological role in the development and function of the reproductive system. PMID: 12351685
36. Transcriptionlal activation driven by the PPARalpha/RXRalpha complex was counteracted by the expression of ERR1 in HeLa cells. PMID: 12914524
37. ERRalpha-/- mice are viable, fertile and display no gross anatomical alterations, with the exception of reduced body weight and peripheral fat deposits. PMID: 14585956
38. Erralpha and GA-binding protein a partner with PGC-1alpha in muscle to form a double-positive-feedback loop that drives the expression of many oxidative phosphorylation genes PMID: 15100410
39. expression of ERRalpha displays a circadian rhythmicity in liver, bone and uterus PMID: 15291745
40. results demonstrate that apoA-IV is a direct ERRalpha target gene and suggest a function for ERRalpha in intestinal fat transport, a crucial step in energy balance PMID: 15466464
41. ERRalpha and MCAD are markedly reduced in the liver, heart, and kidney of mice during the lipopolysaccharide-induced acute phase response. PMID: 16061943
42. ERRalpha activity could have beneficial effects on glucose metabolism in diabetic subjects by two distinct mechanisms: increasing mitochondrial oxidative capacity in peripheral tissues and liver, and suppressing hepatic glucose production PMID: 16267049
43. PGC-1alpha expression in skeletal muscle coordinately upregulate the expression of pyruvate dehydrogenase kinase 4 (PDK4) via the orphan nuclear receptor ERRalpha PMID: 16314495
44. estrogen-related receptor alpha functions through a novel binding site on the Ucp1 enhancer PMID: 17456798
45. ERRs orchestrate a comprehensive genome-wide cardiac transcriptional program. PMID: 17488637
46. ERRalpha may play a critical role in adipocyte differentiation by modulating the expression of various adipogenesis-related genes PMID: 17512501
47. Rb1cc1 is a target gene of ERRalpha, driven by a novel type of recognition sequence. PMID: 18039682
48. study reports age- and sex-specific interaction of estrogen receptor alpha-transactivation domain with p68 RNA helicase; age- and sex-specific interaction of p68 suggests its implication in ERalpha-mediated brain functions during aging PMID: 19025768
49. The up-regulation of ERRalpha might be related to tumor growth and advancement in uterine endometrial cancers. PMID: 19416752
50. Adult female and male ERRalpha-deficient mice displayed a moderate increase in femoral cancellous bone volume and density; osteoblast surface was increased and marrow fat volume decreased in these animals. PMID: 19608650

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KEGG: mmu:26379

STRING: 10090.ENSMUSP00000025906

UniGene: Mm.386776