Recombinant Mouse Synapsin-1 (Syn1)

1. Results implicate SYN1 in the pathogenesis of non-syndromic intellectual disability, showing that alterations of synaptic vesicle trafficking are one possible cause of this disease, and suggest that distinct mutations in SYN1 may lead to distinct brain pathologies. PMID: 28973667
2. This study demonstrated that syn1 affect the rate of release of GABA quanta residing within the Hippocampal Interneurons. PMID: 27335405
3. Synapsin I is localized and produced at mature axon terminals and at immature growth cones. PMID: 27098703
4. HSV-1-infected neurons also exhibite significantly reduced expression of the presynaptic proteins synapsin-1 and synaptophysin. These effects depended on GSK-3 activation and intraneuronal accumulation of Ab PMID: 26487282
5. Functions of synapsins in corticothalamic facilitation: important roles of synapsin I PMID: 26256545
6. Levels of synapsin Ia/b increased in contralateral visual cortex following monocular deprivation. PMID: 25576091
7. SynI mRNA and protein levels are down-regulated in the hippocampus of naive and Morris water maze-treated En2-/- mice. PMID: 25463523
8. age-dependent reduction of phospho-synapsin-Ia reversed by exercise regimen PMID: 24835196
9. This study demonostrated that Epileptic synapsin triple knockout mice exhibit progressive long-term aberrant plasticity in the entorhinal cortex. PMID: 23236212
10. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. PMID: 24312498
11. during chronic modification of neuronal activity and is an essential downstream effector for the Cdk5-mediated homeostatic scaling. PMID: 24849359
12. O-GlcNAcylation of Thr-87 interferes with folding of the ALPS motif, providing a means for regulating the association of synapsin I with SVs as a mechanism contributing to synapsin I localization and RPSV generation. PMID: 24280219
13. Data indicate that in patients carrying the W356x mutation the function of synapsin I is markedly impaired, and support the value of Syn1(-/-) mice as an experimental model mimicking the human pathology. PMID: 23818987
14. Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity. PMID: 23406870
15. This study demonstrated a seizure-inducing potential of regular handling in both Syn1KO and Syn2KO mice during a period between P21 and 4 1/2 months of age. PMID: 23570901
16. the serine residue at 605 of the synapsin-1 peptide, 603QASQAGPGPR612, and the serine residue at 692 of the tau peptide, 688SPVVSGDTSPR698, were found to be potential reciprocal O-GlcNAcylation and phosphorylation sites. PMID: 23807304
17. Synapsin I knock-out mice do not exhibit a linear progression of the epileptic seizure phenotype. PMID: 22846639
18. post-receptor calcium-dependent mechanisms associated with nicotine withdrawal are mediated through beta2-containing nicotinic receptors. PMID: 23313759
19. NPAS4 plays an important role in the structural and functional plasticity of neurons PMID: 23172225
20. In synapsin-1 knock-out mice partial seizures are rare, and generalized seizures are almost absent. PMID: 22236379
21. Analysis of cultured neurons from wild-type and Syn I,II,III-deficient triple knock-out (TKO) mice shows that synaptic vesicles are severely dispersed in the absence of Syns. PMID: 22933803
22. This study demonistrated that Site-specific synapsin I phosphorylation participates in the expression of post-tetanic potentiation and its enhancement by BDNF. PMID: 22539848
23. We conclude that neither synapsin I nor synapsin II are directly involved in the regulation of glucose-stimulated insulin secretion and Ca(2)-dependent exocytosis in mouse pancreatic beta-cells. PMID: 22334712
24. The results of this study show that synapsin is pivotal for maintaining synaptic vesicle cluster integrity and that it contributes to the regulated sharing of vesicles between terminals. PMID: 22442064
25. Synapsin I and II affect distinct excitatory glutamatergic synapses in the hippocampus, synapsin-dependent modulations of synaptic function may use distinct presynaptic response patterns to induce different classes of presynaptic plasticity.[Review] PMID: 21827868
26. The supply rate of vesicle trafficking depresses more rapidly in synapsin knock-outs; the phenotype can be fully explained by changing the value of the single parameter in the model that would specify the size of the local reserve pools. PMID: 21832187
27. findings suggest that seizure behavior in synapsin I and synapsin II KO mice is not solely determined by cortical activity but rather reflects interplay between cortical activity and activity in other brain regions PMID: 21281619
28. As an oligomannose-carrying glycoprotein, synapsin can be released from glial-derived exosomes and promotes neurite outgrowth and neuronal survival by modulating the interactions between glia and neurons. PMID: 21593312
29. Data provide a complete molecular pathway (GR/Egr-1/MAPK/Syn-Ia/Ib) through which stress and glucocorticoids enhance the memory of stress-related events and highlight the function of synapsin-Ia/Ib as molecular effector of the behavioral effects of stress PMID: 20368707
30. the nucleocytoplasmic shuttling of dysbindin-1 regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia. PMID: 20921223
31. Truncation mutagenesis revealed that synapsin Ia targets via distributed binding sites that include domains B, C, and E. Although domain A was not necessary for targeting, its presence enhanced targeting. Domain D inhibited targeting without domain E PMID: 15071120
32. The functions of synapsins were examined by characterizing the phenotype of mice in which all three synapsin genes were knocked out. PMID: 15601943
33. These results suggest that immunophilins are involved in the complex protein networks operating at the presynaptic level and implicate the interaction between cyclophilin B and synapsins in presynaptic function. PMID: 15935056
34. findings show that synapsin I plays a central role in regulating the organization and dynamics of synaptic vesicles in growth cones and that this activity is modulated by cAMP-dependent phosphorylation of the protein PMID: 16093379
35. Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons. PMID: 16373512
36. Synapsin I is a major endogenous substrate for Pcmt1 in mouse brain. PMID: 16443604
37. Deletion of synapsins did not induce significant changes in spontaneous neurotransmitter release or release evoked by isolated action potentials and did not alter the size of the readily releasable vesicle pool. PMID: 16481620
38. Cocaine enhances dopamine release by mobilizing a synapsin-dependent reserve pool of dopamine-containing synaptic vesicles. This capacity to enhance exocytotic release of dopamine may be important for the psychostimulant actions of cocaine. PMID: 16554471
39. Stimulation of chemical synapses was dependent on the presence of F-actin filaments and synapsins I and/or II. PMID: 17569738
40. While both synaptic vesicle number and presynaptic plasticity are independent of synapsin I prior to postnatal day 10, maturation and function of excitatory synapses are dependent on synapsin I from postnatal day 20. PMID: 18606212
41. The data indicate that SynI and SynII have specific and non-redundant functions, and that synaptic dysfunctions associated with synapsin mutations negatively modulate cognitive performances and neuronal survival during senescence. PMID: 18713831
42. The transcriptional expression of synapsin I in mice brain was up-regulated by 20% food restriction, and down-regulated by 60% and 80% food restriction. PMID: 19125380
43. Synapsin I accelerates the kinetics of neurotransmitter release in mouse motor terminals. PMID: 19226605
44. This study described a neuroethological analysis of behavioral elements and relationships between these elements during seizures in synapsin I/II double knockout mouse. PMID: 19236947
45. neurotransmitter regulation in central cholinergic synapses may be less dependent on synapsin I and II compared to the marked alterations seen in the glutamatergic and GABAergic synapses PMID: 19428802
46. blockade of ERK was ineffective on PTE of MF-CA3 synapses in mice lacking synapsin I, 1 of the presynaptic ERK substrates, and triple knockout mice lacking all synapsin isoforms displayed PTE kinetics resembling that of wild-type mice under ERK inhibit PMID: 19487674

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KEGG: mmu:20964

STRING: 10090.ENSMUSP00000080568

UniGene: Mm.439844