Phospho-Syn1 (Ser549) Antibody

Code CSB-PA216484
Size US$360
Image
  • Western blot analysis of extract from rat brain and mouse brain tissue using Synapsin(phospho-Ser549) Antibody using
  • Western blot analysis of extracts from Rat brain tissue or calf intestinal phosphatase (CIP), using Synapsin (phospho-Ser549) Antibody.
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Syn1 Polyclonal antibody
Uniprot No. O88935
Target Names Syn1
Alternative Names Syn1 antibody; Syn-1 antibody; Synapsin-1 antibody; Synapsin I antibody
Raised in Rabbit
Species Reactivity Human,Rat,Mouse
Immunogen Peptide sequence around phosphorylation site of serine 549(P-A-S(p)-P-S)derived from Rat Synapsin
Immunogen Species Mus musculus (Mouse)
Clonality Polyclonal
Purification Method Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Concentration It differs from different batches. Please contact us to confirm it.
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:1000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Earn $30 Amazon Card or 20μL/μg CUSABIO Trial Size Antibody. Details of rewards >>

Target Data

Function Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. Regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level.
Gene References into Functions
  1. Results implicate SYN1 in the pathogenesis of non-syndromic intellectual disability, showing that alterations of synaptic vesicle trafficking are one possible cause of this disease, and suggest that distinct mutations in SYN1 may lead to distinct brain pathologies. PMID: 28973667
  2. This study demonstrated that syn1 affect the rate of release of GABA quanta residing within the Hippocampal Interneurons. PMID: 27335405
  3. Synapsin I is localized and produced at mature axon terminals and at immature growth cones. PMID: 27098703
  4. HSV-1-infected neurons also exhibite significantly reduced expression of the presynaptic proteins synapsin-1 and synaptophysin. These effects depended on GSK-3 activation and intraneuronal accumulation of Ab PMID: 26487282
  5. Functions of synapsins in corticothalamic facilitation: important roles of synapsin I PMID: 26256545
  6. Levels of synapsin Ia/b increased in contralateral visual cortex following monocular deprivation. PMID: 25576091
  7. SynI mRNA and protein levels are down-regulated in the hippocampus of naive and Morris water maze-treated En2-/- mice. PMID: 25463523
  8. age-dependent reduction of phospho-synapsin-Ia reversed by exercise regimen PMID: 24835196
  9. This study demonostrated that Epileptic synapsin triple knockout mice exhibit progressive long-term aberrant plasticity in the entorhinal cortex. PMID: 23236212
  10. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. PMID: 24312498
  11. during chronic modification of neuronal activity and is an essential downstream effector for the Cdk5-mediated homeostatic scaling. PMID: 24849359
  12. O-GlcNAcylation of Thr-87 interferes with folding of the ALPS motif, providing a means for regulating the association of synapsin I with SVs as a mechanism contributing to synapsin I localization and RPSV generation. PMID: 24280219
  13. Data indicate that in patients carrying the W356x mutation the function of synapsin I is markedly impaired, and support the value of Syn1(-/-) mice as an experimental model mimicking the human pathology. PMID: 23818987
  14. Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity. PMID: 23406870
  15. This study demonstrated a seizure-inducing potential of regular handling in both Syn1KO and Syn2KO mice during a period between P21 and 4 1/2 months of age. PMID: 23570901
  16. the serine residue at 605 of the synapsin-1 peptide, 603QASQAGPGPR612, and the serine residue at 692 of the tau peptide, 688SPVVSGDTSPR698, were found to be potential reciprocal O-GlcNAcylation and phosphorylation sites. PMID: 23807304
  17. Synapsin I knock-out mice do not exhibit a linear progression of the epileptic seizure phenotype. PMID: 22846639
  18. post-receptor calcium-dependent mechanisms associated with nicotine withdrawal are mediated through beta2-containing nicotinic receptors. PMID: 23313759
  19. NPAS4 plays an important role in the structural and functional plasticity of neurons PMID: 23172225
  20. In synapsin-1 knock-out mice partial seizures are rare, and generalized seizures are almost absent. PMID: 22236379
  21. Analysis of cultured neurons from wild-type and Syn I,II,III-deficient triple knock-out (TKO) mice shows that synaptic vesicles are severely dispersed in the absence of Syns. PMID: 22933803
  22. This study demonistrated that Site-specific synapsin I phosphorylation participates in the expression of post-tetanic potentiation and its enhancement by BDNF. PMID: 22539848
  23. We conclude that neither synapsin I nor synapsin II are directly involved in the regulation of glucose-stimulated insulin secretion and Ca(2)-dependent exocytosis in mouse pancreatic beta-cells. PMID: 22334712
  24. The results of this study show that synapsin is pivotal for maintaining synaptic vesicle cluster integrity and that it contributes to the regulated sharing of vesicles between terminals. PMID: 22442064
  25. Synapsin I and II affect distinct excitatory glutamatergic synapses in the hippocampus, synapsin-dependent modulations of synaptic function may use distinct presynaptic response patterns to induce different classes of presynaptic plasticity.[Review] PMID: 21827868
  26. The supply rate of vesicle trafficking depresses more rapidly in synapsin knock-outs; the phenotype can be fully explained by changing the value of the single parameter in the model that would specify the size of the local reserve pools. PMID: 21832187
  27. findings suggest that seizure behavior in synapsin I and synapsin II KO mice is not solely determined by cortical activity but rather reflects interplay between cortical activity and activity in other brain regions PMID: 21281619
  28. As an oligomannose-carrying glycoprotein, synapsin can be released from glial-derived exosomes and promotes neurite outgrowth and neuronal survival by modulating the interactions between glia and neurons. PMID: 21593312
  29. Data provide a complete molecular pathway (GR/Egr-1/MAPK/Syn-Ia/Ib) through which stress and glucocorticoids enhance the memory of stress-related events and highlight the function of synapsin-Ia/Ib as molecular effector of the behavioral effects of stress PMID: 20368707
  30. the nucleocytoplasmic shuttling of dysbindin-1 regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia. PMID: 20921223
  31. Truncation mutagenesis revealed that synapsin Ia targets via distributed binding sites that include domains B, C, and E. Although domain A was not necessary for targeting, its presence enhanced targeting. Domain D inhibited targeting without domain E PMID: 15071120
  32. The functions of synapsins were examined by characterizing the phenotype of mice in which all three synapsin genes were knocked out. PMID: 15601943
  33. These results suggest that immunophilins are involved in the complex protein networks operating at the presynaptic level and implicate the interaction between cyclophilin B and synapsins in presynaptic function. PMID: 15935056
  34. findings show that synapsin I plays a central role in regulating the organization and dynamics of synaptic vesicles in growth cones and that this activity is modulated by cAMP-dependent phosphorylation of the protein PMID: 16093379
  35. Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons. PMID: 16373512
  36. Synapsin I is a major endogenous substrate for Pcmt1 in mouse brain. PMID: 16443604
  37. Deletion of synapsins did not induce significant changes in spontaneous neurotransmitter release or release evoked by isolated action potentials and did not alter the size of the readily releasable vesicle pool. PMID: 16481620
  38. Cocaine enhances dopamine release by mobilizing a synapsin-dependent reserve pool of dopamine-containing synaptic vesicles. This capacity to enhance exocytotic release of dopamine may be important for the psychostimulant actions of cocaine. PMID: 16554471
  39. Stimulation of chemical synapses was dependent on the presence of F-actin filaments and synapsins I and/or II. PMID: 17569738
  40. While both synaptic vesicle number and presynaptic plasticity are independent of synapsin I prior to postnatal day 10, maturation and function of excitatory synapses are dependent on synapsin I from postnatal day 20. PMID: 18606212
  41. The data indicate that SynI and SynII have specific and non-redundant functions, and that synaptic dysfunctions associated with synapsin mutations negatively modulate cognitive performances and neuronal survival during senescence. PMID: 18713831
  42. The transcriptional expression of synapsin I in mice brain was up-regulated by 20% food restriction, and down-regulated by 60% and 80% food restriction. PMID: 19125380
  43. Synapsin I accelerates the kinetics of neurotransmitter release in mouse motor terminals. PMID: 19226605
  44. This study described a neuroethological analysis of behavioral elements and relationships between these elements during seizures in synapsin I/II double knockout mouse. PMID: 19236947
  45. neurotransmitter regulation in central cholinergic synapses may be less dependent on synapsin I and II compared to the marked alterations seen in the glutamatergic and GABAergic synapses PMID: 19428802
  46. blockade of ERK was ineffective on PTE of MF-CA3 synapses in mice lacking synapsin I, 1 of the presynaptic ERK substrates, and triple knockout mice lacking all synapsin isoforms displayed PTE kinetics resembling that of wild-type mice under ERK inhibit PMID: 19487674

Show More

Hide All

Subcellular Location Cell junction, synapse, Golgi apparatus
Protein Families Synapsin family
Database Links

KEGG: mmu:20964

STRING: 10090.ENSMUSP00000080568

UniGene: Mm.439844

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

© 2007-2020 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1