Product Details

Purity

>85% (SDS-PAGE)

Target Names

Syp

Uniprot No.

Q62277

Alternative Names

Syp; Synaptophysin; BM89 antigen; Major synaptic vesicle protein p38

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

full length protein

Tag Info

N-terminal His-tagged
Tag-Free

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Target Background

Function

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.

Gene References into Functions

Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration. PMID: 28623327
PSD95 and SYP may originate from the different sites, but they are closely related to the formation and maturation of synapse. PMID: 27916092
The results suggest that the neurological mechanisms of chronic stress on cognition might be associated with a decrease in hippocampal SYN and PSD95 expression, which is critical for structural synaptic plasticity. PMID: 27562628
APP, tau, and synaptophysin were elevated in in the medial preoptic area in both the B6D2F1 and BXB1 matters, suggesting a potential genetic mechanism for inheritance of steroid-independent male sexual behavior. PMID: 26940434
Syp1 clears Syb2 from the presynaptic active zone to prevent short-term depression. PMID: 26854222
The balance between synaptophysin and sybII levels is critical for the correct targeting of sybII to synaptic vesicles and suggests that alterations in synaptophysin levels might affect the localisation of sybII and subsequent presynaptic performance. PMID: 26871701
The high expression of P2X7 receptor and low expression of synaptophysin in the hippocampus of pups may contribute to the neurotoxicity associated with maternal Pb exposure. PMID: 25542768
Trimethyltin decreased synaptophysin but not GAP-43 expression in the mouse hippocampus. PMID: 24001577
These studies suggest that the efficient retrieval of sybII by synaptophysin may be key to maintaining synaptic health and perturbation of this event may contribute to the pathogenesis underlying neurodevelopmental disorders. PMID: 23966691
Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin levels. PMID: 23418567
Melatonin can reduce the expression levels of NF-kappaB p65 and synaptophysin in the brain tissue to protect the brain and slow down the aging process. PMID: 22200709
Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles. PMID: 22908222
Synaptophysin controls synaptobrevin (sybII)traffic in nerve terminals during synaptic vesicle (SV) endocytosis, an interaction that may act as an adjustable regulator of SV retrieval efficiency. PMID: 21957264
Cognitive improvement of schizophrenic histopathology may be related to a restoration of synaptophysin and/or Arc levels in the frontal cortex. PMID: 20817066
synaptophysin regulates at least two phases of endocytosis to ensure vesicle availability during and after sustained neuronal activity. PMID: 21658579
Data demonstrate that protein expression of synaptophysin decreases age-dependently in senescence-accelerated mouse/prone 8 mice and increases in a learning- and memory-dependent manner in KM mice. PMID: 21295146
The alteration of neuronal remodeling proteins in the hippocampus may be an underlying mechanism of venlafaxine in treating post-stroke depression. PMID: 20651837
Synaptophysin regulates activity-dependent synapse formation in cultured hippocampal neurons. PMID: 11792847
synaptophysin targeting to a ubiquitous synaptic vesicle-sized compartment is facilitated by cellugyrin and synaptogyrin PMID: 12928441
Environmental enrichment resulted in increased synaptophysin levels through anterior and posterior areas of the forebrain, hippocampus, thalamus, and hypothalamus, but not the cerebellum. PMID: 15082021
prion replication triggers an abnormal localization of caveolin 1 and synaptophysin, which in turn may alter neuronal function PMID: 15509552
Synaptophysin increased from young to middle-age in females, and from middle-age to old in males; females had higher levels of synaptophysin than males in middle-age only. PMID: 16330151
levels of synaptophysin were significantly higher in mice which learnt to associate the auditory stimulus with fear, in comparison to all non-learning control animals PMID: 18226933
The data indicate that apoE deficiency in KO mice is associated with a delayed recovery of the glomerular area and a slower recovery in Syn concentration in the OB. PMID: 18621483
Data suggest that heparan sulfate oligosaccharides activate degradation of synaptophysin by the proteasome with consequences on synaptic vesicle components that are relevant to clinical manifestations of mucopolysaccharidosis type IIIB. PMID: 19386237
Our observations demonstrate functional consequences of synaptophysin depletion in a living organism. PMID: 19393300
From six months of age, decrease of synaptophysin immunocytochemical detection appeared in fibers under the most external row of outer hair cell, nine momth age found decrease in innear hair cell. PMID: 19565669