Recombinant Mouse Transient receptor potential cation channel subfamily A member 1 (Trpa1), partial

1. The present study determined that cold hypersensitivity in the early phase of DPN is mediated through the TRPA1 sensitization during diabetic vascular impairment in the STZ-induced diabetic mouse model. PMID: 29968518
2. Study utilizing large-scale recessive genetics screen of randomly mutagenized mice using a highly robust 2-methyl-2-thiazoline-evoked innate fear assay found that the Trpa1-mediated chemosensory system, in addition to classical olfactory system, plays a central role in mediating predator odor-evoked innate fear/defensive behaviors in mice. PMID: 29795268
3. Activation of Schwann cell TRPA1 evoked NADPH oxidase 1-dependent H2O2 release, and silencing or blocking Schwann cell NOX1 attenuated nerve injury-induced macrophage infiltration and oxidative stress. PMID: 29192190
4. Results indicated that inhibition of TRPA1 could prevent Dox-induced cardiomyocyte apoptosis in mice by inhibiting oxidative stress, inflammation, and ER stress. PMID: 29682158
5. Blocking prolyl hydroxylation reveals TRPA1 sensitization to reactive oxygen species (ROS), which enables TRPA1 to convert ROS signalling into cold sensitivity. PMID: 27628562
6. The stimulation of TRPA1 ion channels in CMs results in activation of a CaMKII-dependent signaling pathway resulting in modulation of intracellular Ca(2+) availability and handling leading to increases in CM contractile function. Cardiac TRPA1 ion channels may represent a novel therapeutic target for increasing the inotropic and lusitropic state of the heart. PMID: 28792844
7. Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain. PMID: 27356469
8. The results obtained with dorsal root ganglia neurons from transient receptor potential cation channel, subfamily A, member 1 channels (TRPA1)-/- mice, TRPM8-/- mice, and wild-type mice, using selective antagonists of TRPA1 and TRPM8 channels, as well as HEK293 cells stably expressing human, TRPA1, indicate that responses to cold, are mediated by TRPA1 channels. PMID: 28408328
9. This study demonstrated that botulinum neurotoxin A doenregulation of Trpa1 in the dorsal root ganglia in mice PMID: 28410268
10. The TRPA1 channel may play a crucial role in neuronal development and oligodendrocyte maturation and be a potential regulator in emotion, cognition, learning and memory, and social behavior. PMID: 27194300
11. Results identify AMPK as a previously unknown regulator of TRPA1 channels. AMPK modulation of TRPA1 could thus serve as an underlying mechanism and potential therapeutic molecular target in painful diabetic neuropathy. PMID: 29025860
12. This study demonstrated that TRPA1 regulates mitogen-activated protein kinase pathways, as well as transcription factor c-Jun and a proapoptotic Bcl-2 family member (Bak) expression resulting in enhanced oligodendrocyte apoptosis. PMID: 27568827
13. Reducing agents reverse thiazolidine-induced TRPA1 activation, and mutagenesis studies show that nucleophilic cysteine residues in TRPA1 are critical, suggesting an activation mechanism involving thioreactive chemical reactions. In vivo studies show that thiazolidine induces acute pain and inflammation in mouse and these responses are specifically dependent on TRPA1. PMID: 28130183
14. Data show that trigeminal transient receptor potential ankyrin 1 in the nasal cavity play an essential role in irritant-induced bradypnea. PMID: 28039411
15. results provide evidence from two complementary and independent Advillin-Cre mouse lines indicating that TRPA1 specifically expressed within sensory neurons is essential for normal baseline sensitivity to multiple types of mechanical stimuli but not hot or cold temperature stimuli. PMID: 28303259
16. This mechanistic pathway underlying TRPA1-mediated vasodilatation may be important in understanding the role of TRPA1 in pathophysiological situations. PMID: 27189253
17. The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1. PMID: 27325418
18. TRPA1 channels trigger vesicle release in sensory neurons by releasing Calcium from lysosome-like organelles. PMID: 27799370
19. Single exposure to acrolein causes cardiac dysfunction through TRPA1 activation. PMID: 27746315
20. study revealed that TRPA1 positively modulates the mechanical hyperalgesia induced by B1 receptor activation in the spinal cord and that the classical GPCR downstream molecules PMID: 27823962
21. findings propose that, in the constriction of the infraorbital nerve model of trigeminal neuropathic pain, pain-like behaviours are entirely mediated by the TRPA1 channel. PMID: 26984186
22. Activation of enterocyte transient receptor potential cation channel subfamily A member 1(TRPA1) by food components has the potential to facilitate nutrient absorption PMID: 27735854
23. contributes to cinnamaldehyde effects in LPS-induced systemic inflammatory response syndrome PMID: 26922677
24. Our study demonstrated the novel role of the TRPA1 channel in astrocytes under an amyloid beta-elicited inflammatory environment and thus its potential involvement in Alzheimer's disease pathogenesis PMID: 27121378
25. Cold exposure caused mechanical hyperalgesia in an experimental arthritic model in a TRPA1-dependent manner. PMID: 26754745
26. In TRPA1 knock-out mice hypersensitivity and impaired weight bearing in osteoarthritis limbs were significantly decreased. PMID: 26746673
27. Trpa1 is involved in the ocular itch response in allergic conjunctivitis. PMID: 26521042
28. TRPA1 was found to mediate acute inflammation and the development of degenerative cartilage changes and joint pain in MIA-induced experimental OA in the mouse. PMID: 26521748
29. exposure to cigarette smoke extract initially causes an increase in the extracellular level of ROS, which in turn activates lung epithelial TRPA1 PMID: 26504357
30. K14Cre-Trpa1fl/fl mice had a big mechanosensitivity deficit at the behavioral and primary afferent levels, and decreased mechanically-evoked ATP release. This is not due to low Trpa1 because these cells even in controls have little if any Trpa1. PMID: 26978657
31. nicotinic receptors contribute to the sensory effects of cigarette smoke on the trachea, which are dominated by TRPA1 PMID: 26472811
32. propofol-induced depressor responses in vivo are predominantly mediated by TRPA1 ion channels. PMID: 25830814
33. The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives PMID: 25765567
34. Deoxynivalenol induced cholecystokinin and glucagon-like peptide 1 release by enteroendocrine cells in mediated by casR/TRPA1 signaling. PMID: 25787141
35. TRPA1 mediates MSU crystal-induced inflammation and pain in experimental models supporting the role of TRPA1 as a potential mediator and a drug target in gout flare. PMID: 25658427
36. TRPA1 is essential for the vascular response to environmental cold exposure. PMID: 25501034
37. Lipopolysaccharide exerts fast, membrane delimited, excitatory actions via TRPA1, a transient receptor potential cation channel that is critical for transducing environmental irritant stimuli into nociceptor activity. PMID: 24445575
38. TRPA1 seems to be a sentinel for environmental chemicals and induces avoidance behaviors and waking by way of the trigeminal system. PMID: 24172941
39. Activation of HTR7 promoted opening of the ion channel TRPA1, which in turn triggered itch behaviors. Acute itch triggered by serotonin or a selective serotonin reuptake inhibitor required both HTR7 and TRPA1, as did development of atopic dermatitis. PMID: 26074006
40. TRPA1 is a major mediator of the proinflammatory/proalgesic actions of aromatase inhibitors PMID: 25484020
41. TRPA1 is upregulated in colitis and its activation exerts protective roles by decreasing the expressions of several proinflammatory neuropeptides, cytokines and chemokines PMID: 25265225
42. The blockade of TRPA1 signalling mediates antidepressant- and anxiolytic-like actions in mice PMID: 24846744
43. TRPA1 activation caused an increase in GLP-1 secretion from primary murine intestinal cultures and GLUTag cells, an effect that was abolished in cultures from trpa1(-/-) mice PMID: 25325736
44. TRPA1-mediated lipid increases may underlie mechanical sensitization with inflammation. PMID: 25271163
45. Ischemia-reperfusion in a hindlimb model, induces oxidative stress, which activates TRPA1 channels to provoke postischemic licking. PMID: 25228635
46. In a model of interstitial cystitis related bladder hyperalgesia, there was an increase in TRPA1 expression, and a TRPA1 antagonist reverse the hyperalgesia. PMID: 24704367
47. TRPA1 activation by H2O2 mediates the entire inflammatory response in an acute gout attack rodent model PMID: 24780252
48. Unsaturated aldehydes are potent aliphatic stimulants for cholecystokinin secretion through the activation of TRPA1. PMID: 24357536
49. TRPA1 is contained in very specific enteroendocrine cell populations. PMID: 24442491
50. The study unravelled the role of TRPA1 in shaping the ventilatory response to low-intensity hypoxia, liable to be mediated by vagally innervated respiratory chemosensors of lower functional rank. PMID: 24245768

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KEGG: mmu:277328

STRING: 10090.ENSMUSP00000043594

UniGene: Mm.186329