Recombinant Mouse Urotensin-2 (Uts2)

Code CSB-YP886406MO
MSDS
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Source Yeast
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Code CSB-EP886406MO
MSDS
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Source E.coli
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Code CSB-EP886406MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP886406MO
MSDS
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Source Baculovirus
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Code CSB-MP886406MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Uts2
Uniprot No.
Alternative Names
Uts2; Ucn2; Urotensin-2; Urotensin II; U-II; UII
Species
Mus musculus (Mouse)
Expression Region
110-123
Target Protein Sequence
Q HGAAPECFWK YCI
Protein Length
Cytoplasmic domain
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Highly potent vasoconstrictor.
Gene References into Functions
  1. role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions PMID: 29133126
  2. IRF3 expression and activation depend on the signal transduction of the the urotensin II/urotensin receptor (UII/UT) system, and play important roles in UII/UT-mediated immune inflammatory injury in the liver PMID: 27448985
  3. UII/UTR system plays a role in lipopolysaccharide (LPS)/D-galactosamine (GalN)-induced acute liver failure. PMID: 23755157
  4. Data suggest that aortic urotensin II (UII) is increased in diabetes-associated atherosclerosis in humans and mice; diabetes-associated plaque development is attenuated by UII/UII receptor antagonism in in vitro (human) and in vivo (mouse) settings. PMID: 23344731
  5. It is believed that U-II is an important mediator in Systemic sclerosis. PMID: 22886350
  6. role of urotensin II gene deletion in atherosclerosis and suggest that the use of pharmaceutical agents aimed at blocking the urotensin II pathway may provide a novel approach in the treatment of atherosclerosis. PMID: 22723440
  7. 17 amino acid seq and effects on body temperature, water and food consumption, locomotion, exploratory behavior, etc. PMID: 16160878
  8. mouse UII is expressed in a subpopulation of motoneurons in the spinal cord PMID: 16361078
  9. In the CNS UII mRNAs are expressed in brainstem and spinal motoneurons, also expressed in the medial vestibular nucleus, locus coeruleus and the ventral medulla. PMID: 18710417
  10. increased plasma urotensin II level stimulates oxidized low-density lipoprotein and reactive oxygen species production and macrophage foam cell formation PMID: 18806619
  11. Elevated expression of Uts2 in skeletal muscle of diabetic mouse is reported. PMID: 19323985

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Subcellular Location
Secreted.
Protein Families
Urotensin-2 family
Tissue Specificity
Brain specific. Predominantly expressed in motoneurons of the brainstem and spinal cord.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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