Recombinant Mouse Zinc finger E-box-binding homeobox 2 (Zeb2), partial

1. miR-192 was a critical factor of HS formation and facilitated skin fibrosis by targeting directly SIP1. PMID: 28884252
2. The miR-200 family is specifically induced during late neuronal differentiation stages. Using in vivo strategies we interfered with the entire miR-200 family in loss- and gain-of-function settings, showing a role of miR-200 in neuronal maturation. This function is mediated by targeting the transcription factor Zeb2. PMID: 27767083
3. Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate PMID: 27930303
4. We demonstrate that neocortical neurons that have only one copy of Sip1 (heterozygous, Sip1(fI/wt)), are more sensitive to both NMDA- and AMPA- receptors agonists as compared to wild type neurons (Sip1(wt/wt)). PMID: 28455101
5. miR-30a-5p directly targeted the 3'-UTR of ZEB2 and suppressed clear cell renal cell epithelial-mesenchymal transition. PMID: 28569782
6. Zeb2 is critical in embryonic stem cells for exit from the epiblast state. PMID: 27739137
7. regulates the morphogenesis of mesenchyme-derived nephrons and is required for proximal tubule development and glomerulotubular junction formation PMID: 27591083
8. characterization of differentiation dynamics reveals that Sip1 has a role in promoting the timely differentiation of retinal interneurons, assuring generation of the proper number of the diverse neuronal and glial cell subtypes that constitute the functional retina in mammals. PMID: 27385012
9. Collectively, the results demonstrate that Zeb2 controls adult hematopoietic differentiation and lineage fidelity through widespread modulation of dominant signaling pathways that may contribute to blood disorders. PMID: 27683414
10. Zeb2 controls Schwann cell maturation by recruiting HDAC1/2-NuRD complexes and inhibiting a Notch-Hey2 signaling axis PMID: 27294509
11. that Zeb2, although undetectable in adult Schwann cells, has a latent function throughout life PMID: 27294512
12. ZEB2 transcriptionally represses genes that regulate myeloid differentiation, including genes involved in cell adhesion and migration; epigenetic silencing of the miR-200 family microRNAs affects ZEB2 expression. PMID: 27756750
13. Zeb2 regulates commitment to both the cDC2 and pDC lineages through repression of Id2. PMID: 27185854
14. SIP1 plays an essential role in lipid metabolism during the liver regeneration process and might be a regulator of liver regeneration following liver injury. PMID: 26936023
15. Authors systematically generated de novo Zeb2 Deltaex7/+ mice by inducing the Zeb2 mutation in the germ cells PMID: 26319231
16. Data indicate that T-box transcription factor TBX21 (T-bet) is necessary and sufficient to induce Zeb2 protein expression. PMID: 26503444
17. Data indicate that zinc-finger transcription factor ZEB2 is responsible for the balance between terminal differentiation and formation of memory CD8(+) T cells. PMID: 26503445
18. Data indicate that the coordinated actions of T-box transcription factor TBX21 (T-bet) and zinc finger homeobox 1b protein ZEB2 outline a genetic pathway that forces commitment of cytotoxic T lymphocyte (CTL) to terminal differentiation. PMID: 26503446
19. This study identify the sphingosine 1-phosphate (S1P) receptor 1 (S1P1) as one of the key players that govern the switch from tangential to radial migration of postnatally generated neuroblasts in the olfactory bulb. PMID: 26446219
20. ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling. PMID: 25565005
21. SIP1 has a role in positioning of somite boundaries in the mouse embryo PMID: 16127714
22. first demonstration of the significance of Smad interaction in modulating Sip1 activity PMID: 16162653
23. This study suggested that Sip1 restrains the production of signaling factors in postmitotic neurons that feed back to progenitors to regulate the timing of cell fate switch and the number of neurons and glial cells throughout corticogenesis. PMID: 19838179
24. The results of this study revealed that Sip1-mediated antagonism of inhibitory signaling is critical for promoting CNS myelination and point to new mediators for myelin repair. PMID: 22365546
25. Sip1 (Zeb2) is a novel developmental regulator of visceral motoneuron differentiation. PMID: 22833130
26. A short Smad-binding domain stretch of Sip1 is part of an extended alpha-helix that may fit the binding to a hydrophobic corridor within the MH2 domain of activated Smads. PMID: 24146916
27. Authors identify a transcriptional signaling network in which the EMT transcription factor ZEB2 regulates MITF levels to control melanocyte differentiation. PMID: 24769727
28. Zeb2 expression in the epidermis leads to hyperproliferation due to the combined downregulation of different tight junction proteins compromising the epidermal barrier. PMID: 24573695
29. Loss of Ntf3, by contrast, causes an increase in layer VI neurons but does not rescue the Sip1 mutant phenotype, implying that other parallel pathways also control the timing of progenitor cell fate switch. PMID: 25085976
30. Sip1 upregulates in lens epithelial cells (LECs) by 48 hours, but analysis of Sip1 knockout lenses demonstrated that Sip1 does not play a major role in EMT or fiber cell differentiation after surgery. PMID: 25082886
31. study describes SIP1-EGFP fusion protein expression during brain development; SIP1-EGFP expression was observed in the pyramidal neurons of the hippocampus, the dentate gyrus and the postmitotic neurons in the cerebral cortex PMID: 24243579
32. these data imply that Sip1 plays a major role in reprogramming the lens vesicle away from a surface ectoderm cell fate towards that necessary for the development of a transparent lens PMID: 24161570
33. Zeb2 is involved in the development of primary sensory dorsal root ganglia neurons PMID: 23861142
34. Intercellular FGF signaling induces Zfhx1b, which promotes the development of definitive neural stem cells subsequent to an initial neural specification. PMID: 22594450
35. Expression of both Zeb2 was detected in the mesenchyme of the mouse palate, while miR-200b was expressed in the medial edge epithelium. PMID: 22261924
36. results suggest that Zeb2, which were mediated by BMP4, play an important role in neural-crest-derived craniofacial organ morphogenesis, such as tooth development. PMID: 22350174
37. The results indicate that the transcription factor Zeb2 controls the expression of molecules thereby regulating signaling in mast cells. PMID: 22561153
38. Sip1 controls the transduction properties of heat-sensitive primary sensory neurons and thus thermal pain sensitivity in a novel manner via coordinated changes in dorsal root ganglion-neuron voltage-gated ion channels. PMID: 21862221
39. Study genetically identifies multiple putative microRNA decoys for PTEN, validates ZEB2 mRNA as a bona fide PTEN ceRNA, and demonstrates that abrogated ZEB2 expression cooperates with BRAF(V600E) to promote melanomagenesis. PMID: 22000016
40. Zeb2-deficient hematopoietic stem/progenitor cells fail to properly colonize the fetal liver and/or bone marrow and show enhanced adhesive properties associated with increased beta1 integrin and Cxcr4 expression. PMID: 21355089
41. Demonstrate that the miR-200 family and Sip1/ZEB2 transcription factor are regulated by NO, indicating an unprecedented molecular circuitry important for telomerase regulation and early differentiation of embryonic stem cells. PMID: 21233447
42. the actions of GH on ZEB2 and P- and E-cadherin expression play a role in the pathogenesis of microalbuminuria of DN. PMID: 20682777
43. Our data suggest that definitive NSC fate specification in the mouse neurectoderm is facilitated by FGF activation of Zfhx1b. PMID: 20459606
44. Zeb2 and Ras pathway activation promotes B-lineage leukemic transformation in concert with CALM-AF10. PMID: 20007546
45. Expression of miR-200, which promotes a mesenchymal to epithelial cell transition (MET) by inhibiting Zeb2 expression, unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines PMID: 19787069
46. Mutations in this gene coding for Smad-interacting protein-1 are implicated in the etiology of a dominant form of Hirschsprung disease-mental retardation syndrome of humans. PMID: 12522767
47. Present in a broad area around developing tendon in embryonic limbs; some overlap with pattern of myogenic differentiation. PMID: 12609600
48. Here we document extensively the structure and transcriptional pattern of the mouse SIP1 gene (Zfhx1b) and compare it to homologues from other species. PMID: 13679026
49. ZFHX1B is strongly transcribed at an early stage in the developing peripheral and central nervous systems of both mice and humans, in all neuronal regions of the brains of 25-week human fetuses and adult mice, and in numerous nonneural tissues. PMID: 15006694
50. the Zfhx1b protein expression domain in mouse embryos and correlates this with a novel mouse model involving a conditional mutation in the Zfhx1b gene in neural crest precursor cells PMID: 17478475

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KEGG: mmu:24136

STRING: 10090.ENSMUSP00000028229

UniGene: Mm.440702