Recombinant Mouse cAMP-dependent protein kinase type I-alpha regulatory subunit (Prkar1a)

1. This mouse knockout model supports the role of prkar1a as a tumor suppressor gene in the pancreas and points to the PKA pathway as a possible therapeutic target for these lesions. PMID: 27803029
2. This model, the first describing the germline expression of a PRKAR1A mutation causing dominant repression of cAMP-dependent PKA, reproduced the main features of acrodysostosis 1 in humans. PMID: 27589370
3. These results therefore provide new information on the complex regulation of cellular death under endoplasmic reticulum stress conditions and bring new insights on the conditions that regulate the pro- versus anti-death functions of PKA. PMID: 27341185
4. This study demonstrated that loss of one Prkar1a allele was associated with a significant increase in PKA activity in the basolateral (BLA) and central (CeA) amygdala and ventromedial hypothalamus (VMH) in both Prkar1a(+/-) and Prkar1a(+/-)/Prkaca(+/-) mice. PMID: 26992826
5. Kidney-specific loss of Prkar1a induced renal cystic disease and markedly aggravated cystogenesis in the Pkd1(RC) models. PMID: 28615245
6. data demonstrate that haploinsufficiency for either one of the type-II regulatory subunits improved the bone phenotype of mice haploinsufficient for Prkar1a PMID: 26246497
7. PKARIalpha oxidation is an essential step in the angiogenic pathway. PMID: 26258640
8. PRKAR1A gene and its locus are altered in mixed odontogenic tumors. Expression is decreased in a subset of tumors, and Prkar1a(+) (/) (-) mice do not show abnormalities, which indicates that additional genes play a role in this tumor's pathogenesis. PMID: 25870248
9. Prkar1a activation enhances beta-catenin transcriptional activity through nuclear localization to PML bodies. PMID: 25299576
10. Loss of Prkar1a can only promote tumorigenesis when Prkar1a-mediated apoptosis is somehow countered. PMID: 25012505
11. Data show that mammary-specific loss of Prkar1a leads to elevated type-II PKA isozyme activation and this is sufficient to drive breast carcinogenesis. PMID: 24662820
12. Results show that mouse Prkar1a and human PRKAR2A exhibited a dynamic spatio-temporal expression in tooth development, whereas neither human PRKAR1A nor mouse Prkar2a showed their expression in odontogenesis. PMID: 24755349
13. Ablation of Prkar1a interferes with signaling pathways necessary for osteoblast differentiation. PMID: 24506536
14. This study demonstrated a critical role for cytoplasmic RI-PKA holoenzyme in gene regulation and the overall physiological function of Striatal medium spiny neurons. PMID: 24695708
15. hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 induces cardiomyocyte apoptosis. PMID: 24307699
16. Prkar1a was found to play a critical role in peripheral nerve development. PMID: 24227708
17. Dysregulated protein kinase A activity in the amygdala-prefrontal cortex circuitry in Prkar1a(+/-) mice is associated with behavioral phenotype of anxiety and a bias for threat PMID: 23531435
18. PKA activation through mutation in Prkar1a is sufficient to initiate Rac1 signaling, with subsequent reduction of Nf2 and schwannomagenesis. PMID: 23045281
19. Prkar1a is indeed a tumor suppressor in the thyroid and that loss of this gene leads to hyperthyroidism and follicular thyroid cancer PMID: 22514108
20. Analysis of protein kinase A activity showed the loss of one Prkar1a allele led to an increase in basal and cAMP-stimulated kinase activity in both the basolateral and central amygdala PMID: 22024111
21. PRKAR1A enables protein kinase A to phosphorylate BimEL PMID: 21151042
22. Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. PMID: 20697156
23. Observations provide evidence of the essential role of proper regulation of PKA during the ossification of the bones of the skull PMID: 20534695
24. a key role for AKAP-targeted PKA in control of heart rate and contractile function PMID: 20581396
25. R1alpha loss results in improper maintenance and centrifugal expansion of cortisol-producing fetal adrenocortical cells with concomitant regression of adult cortex. PMID: 20548949
26. Prkar1a haploinsufficiency leads to increase in tumors in the Trp53+/- or Rb1+/- backgrounds by dysregulation of the cell cycle and Wnt signaling. PMID: 20080939
27. Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. PMID: 20197278
28. perilipin expression and phosphorylation state are critical regulators of lipid storage and hydrolysis in ACS1/FATP1 cells. PMID: 11751901
29. AP7, which interacts with PBR and the PKA regulatory subunit RIalpha, is present in adrenal and gonadal cells and is found in mitochondria. Overexpression of full length PAP7 increased hormone-induced steroid production. PMID: 12530641
30. Data show that neuregulin increases acetylcholine receptor delta subunit gene transcription, in part by the activation of protein kinase A/CREB, an alternative route to the previously reported ERK signaling pathway. PMID: 12727221
31. protein kinase A RIalpha has a role in inhibiting carcinogen-induced mammary neoplasms PMID: 15240549
32. concluded that although PRKAR1A haploinsufficiency does predispose to tumorigenesis, distinct secondary genetic events are required for tumor formation PMID: 15371594
33. the tTA/X2AS mouse line with a downregulated Prkar1a gene replicates several of the findings in Carney complex patients and their affected tissues, supporting the role of RI as a candidate tumour suppressor gene PMID: 15591278
34. RIalpha antisense produces anticarcinogenic effects by increasing DMBA detoxification in the liver and activating DNA repair processes in the mammary gland by downregulating PKA-1 [review] PMID: 16394142
35. These results demonstrate that RIalpha is required for regulating PKA activity in maturing oocytes and that compensatory upregulation of RII does not occur. PMID: 16937372
36. Phosphorylated-mTOR levels and mTOR activity were dramatically increased in prkar1a-/- cells. PMID: 16963469
37. Prkar1a(+/-) mice develop bone tumors with high frequency and primary cultures of tumoral bone exhibited the expected decrease in Prkar1a protein. PMID: 17932105
38. Data indicate that complete loss of Prkar1a is sufficient to allow the formation of pituitary tumors and abnormalities of the GH axis, in close analogy to human patients with CNC. PMID: 17975024
39. Loss of Prkar1a from the heart causes myocardial development failure, cardiac failure & embryonic demise. These changes may be due to suppression of cardiac-specific transcription by increased protein kinase A activity, leading to myxoma-like changes. PMID: 18316483
40. data indicate that PKA dysregulation triggered by loss of Prkar1a causes Schwann cell tumorigenesis through pathways that overlap, but are distinct from, those that cause NF1 and NF2 PMID: 18953430
41. The protein kinase cAMP dependent regulatory type I alpha exhibited a uniform distribution throughout the sarcomer or weak and broad striations overlapping with F-actin signals. PMID: 19263518
42. In mouse lung fibroblasts, silencing of the PKARIalpha increased the phosphorylation and activation of RSK1. PMID: 19570980

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KEGG: mmu:19084

STRING: 10090.ENSMUSP00000056500

UniGene: Mm.30039