Recombinant Rat Amiloride-sensitive sodium channel subunit beta (Scnn1b), partial

1. deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP. PMID: 27941075
2. Decreased expression of Scnn1b/g and activation of ENaC could be involved in attenuation of the aortic baroreceptor sensitivity in congestive heart failure. PMID: 26297031
3. level of ENaC-alpha expression decreased 0.50-fold and 0.55-fold at 6 and 12 h after an injection of LPS into the middle ear cavity PMID: 22830999
4. ENaC-gamma and -beta play an important role as mechanosensitive ion channels initiating pressure-induced myogenic responses in rat posterior cerebral arteries. PMID: 22090066
5. Data indicate that functional ENaC (subunits Scnn1a, Scnn1b, and Scnn1g) may affect firing patterns of magnocellular cells (i.e., large neurons) in supraoptic nucleus and paraventricular nucleus and thus control secretion of vasopressin and oxytocin. PMID: 22045317
6. Persistent high expression of alphaENaC and increase in apical localization of beta and gammaENaC may contribute to greater retention of sodium in salt-resistant rats on a high-salt diet. PMID: 21423289
7. Each of the beta-subunit isoforms (beta1-beta4) of sodium channel was expressed in neonatal cardiac cells. PMID: 19426735
8. elucidate key aspects of ENaC trafficking and turnover rates in mammalian kidney epithelial cells PMID: 11773057
9. Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation PMID: 11805112
10. hypoxia-induced inhibition of amiloride-sensitive sodium channel activity is mediated by decreased apical expression of ENaC subunits PMID: 12372821
11. inhibitory effect of cAMP-activated CFTR on ENaC is due to a decrease in channel open probability. PMID: 12548398
12. mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin PMID: 12759227
13. ATP regulation of ENaC may be involved in the fine-tuning of ENaC activity under physiologic and pathophysiologic conditions PMID: 12876281
14. segment-specific downregulation of beta-ENaC and gamma-ENaC in the cortical and outer medullary collecting duct, chief sites for collecting duct sodium reabsorption, in rats with a lithium-induced increase in fractional excretion of sodium. PMID: 12928314
15. Modulation of ENaC Po by endogenous epithelial serine proteases is potentially important regulator of epithelial Na+ transport, distinct from regulation achieved by hormone-induced plasma membrane insertion of channels. PMID: 12967915
16. TNF-alpha decreased the expression of the alpha-, beta-, and gamma-subunits of epithelial sodium channel (ENaC) mRNA to 36, 43, and 16% of the controls after 24-h treatment and reduced to 50% the amount of alpha-ENaC protein in lung epithelium PMID: 14514522
17. The absence of stimulation of ENaCalpha mRNA expression in collecting ducts suggests the physiological significance of ENaCbeta and gamma mRNA for acute regulation by vasopressin. PMID: 14567502
18. A heterooligomer composed of alpha-, beta-, and gamma-ENaC may be the molecular basis of the native channels, which are responsible for amiloride-sensitive electrogenic Na+ absorption in rat rectal colon. PMID: 14576089
19. Results suggest that there are different translational efficiencies for epithelial sodium channel subunits alpha, beta and gamma, and that perinatal processes globally modulate lung mRNA translation. PMID: 14672917
20. the increased or sustained expression of ENaC subunits combined with increased apical targeting in the distal tubule, connecting tubule, and collecting duct are likely to play a role in the sodium retention associated with PAN-induced nephrotic syndrome PMID: 15075188
21. inhibitory effect of [Cl-]i occurred regardless of the presence or absence of net Cl- transport. PMID: 15161604
22. Alpha-, beta- and gamma-ENaC were extensively labeled in the inner ear. Functional ENaC in the labyrinth may work in concert with other Na+ and K+ transport molecules to regulate endolymph and to maintain homeostasis in the inner ear. PMID: 15219314
23. expressed in vascular smooth muscle cells; data suggest that DEG/ENaC proteins are required for vessel responses to pressure and are consistent with the evolutionary conservation of mechanosensory function of DEG/ENaC proteins PMID: 15381679
24. Steady state renal mRNA of ENaC alpha, beta and gamma were unchanged in liver cirrhosis. PMID: 15956070
25. ENaC mRNA and protein expression are not increased in the early phase of unilateral puromycin aminonucleoside-induced nephrotic syndrome PMID: 16020936
26. A role is confirmed for the carboxyl terminus of betaENaC for chloride ion-dependent inhibition of the Na+ channel, which may be part of a complex regulation of ENaC by cystic fibrosis transmembrane conductance regulator. PMID: 16027156
27. the binding of active Nedd4-2 to ENaC is a crucial step in the mechanism of ENaC inhibition by progesterone PMID: 16172119
28. ENaC stimulation by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's beta- and gamma-subunit PMID: 16476738
29. Salt restriction increased the abundance of the beta-subunit of ENaC and produced an endoglycosidase H (Endo H)-resistant pool of this subunit. PMID: 16554417
30. fully glycosylated form of beta-ENaC in Na-depleted animals was observed mainly in outer & inner medulla. findings suggest that capability of hormone-regulated, channel-mediated Na reabsorption by the nephron extends into outer medullary collecting duct. PMID: 17200158
31. Results suggest that the ENaC PY motifs (and Nedd4-2) primarily regulate channel internalization but also affect cAMP-dependent replenishment, providing important insight into the Liddle syndrome defects. PMID: 17605762
32. Epidermal growth factor inhibits sodium absorption via an ERK1/2-mediated down-regulation of Scnnb1. PMID: 17724164
33. ENaC beta is functionally related to regulatory volume increase and hypertonicity-induced cation channel activation in rat hepatocytes PMID: 17926064
34. Dietary sodium chloride induced translocation of Scnn1b from intracellular regions to the cell membrane of vascular smooth muscle cells. PMID: 18024548
35. Expressed at the apical membrane of the principal cells in rats; a low-Na diet or aldosterone perfusion increases expression. PMID: 18504317
36. support a model in which protons modulate ENaC gating by relieving Na(+) self-inhibition PMID: 18990692
37. Altered renal expression of Scnn1b in protein-deprived rats. PMID: 19202345
38. ENaCbeta is a key mechanotransducing channel in the periodontal Ruffini endings. Probably, the terminal Schwann cells together with the axon terminals regulate mechanotransduction in the periodontal endings PMID: 19420735

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KEGG: rno:24767

STRING: 10116.ENSRNOP00000063755

UniGene: Rn.9807